eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | down syndrome |
| Comorbidity | C0002395|alzheimer disease |
| Sentences | 5 |
| PubMedID- 22410580 | alzheimer disease: treatment of alzheimer disease in down syndrome. |
| PubMedID- 23400708 | Apoe4 is a major genetic risk factor for alzheimer disease and is associated with dementia in down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders. |
| PubMedID- 24558640 | We propose that sleep disruption is a lever arm that influences how cognition emerges in development and then declines in response to alzheimer disease in people with down syndrome. |
| PubMedID- 22084131 | Conclusions: florbetapir pet can be used to detect increased cerebral-to-cerebellar fibrillar abeta burden in a down syndrome patient with alzheimer disease, even in the presence of frequent amyloid angiopathy and diffuse plaques in the cerebellum. |
| PubMedID- 26243569 | Further study of the mechanisms underlying the development of alzheimer disease in people with down syndrome could provide insights into the mechanisms that cause dementia in the general population. |
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