eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cutis laxa |
| Comorbidity | C0598608|hyperhomocysteinemia |
| Sentences | 1 |
| PubMedID- 21915169 | Plasma homocysteine has emerged as a risk factor for cardiovascular disease,21 and even mildly elevated homocysteine can cause an exacerbation of neointima formation in rat carotid arteries after endothelial injury.22 mild hyperhomocysteinemia is also associated with metalloproteinase-related elastolysis and subsequent structural deterioration in the minipig arteries, which may be one of the major events underlying the epidemiological association between mild hyperhomocysteinemia and arterial disease.23 a methioninerich diet induces hyperhomocysteinemia with associated diffuse arterial lesions, smooth muscle cell hyperplasia, endothelial alterations, and elastic lamina dislocation.24 this study, as well as previous studies,3,6,7 demonstrates that vegetarians have lower vitamin b12 and elevated plasma homocysteine, which may attenuate the favorable lipid effects of vegetarian diets on arterial stiffness. |
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