eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cushing syndrome |
| Comorbidity | C0001622|hypercortisolism |
| Sentences | 6 |
| PubMedID- 21308315 | The hypercortisolism in cushing's syndrome increases the risk of infections as a result of the immunosuppressive effect of glucocorticoids. |
| PubMedID- 22612409 | The usual diagnostic procedures for investigating endogenous hypercortisolism in patients with cushing's syndrome can be applied in obese dysmetabolic patients, although their sensitivity and specificity seem to be significantly reduced when dealing with subtle abnormalities of cortisol homeostasis.38 with these limitations, a series of studies performed in either epidemiological or clinical settings have investigated acth and cortisol concentrations in basal conditions—with repeated measurements to investigate daily chronobiological changes, during dynamic studies following stimulation with different neuropeptides or psychological stress tests, or by suppression with dexamethasone—to challenge the responsiveness to the inhibitory feedback system.34 in addition, there are studies evaluating glucocorticoid receptor density in different tissues, including adipose tissue. |
| PubMedID- 25597938 | As a glucocorticoid receptor antagonist, mifepristone has been widely used to treat hypercortisolism in patients with refractory cushing's syndrome, major depression with psychotic features, and glaucoma2. |
| PubMedID- 22527617 | Recent evidence suggests that correction of hypercortisolism in cushing's syndrome (cs) may not lead to complete remission of the clinical abnormalities associated with this condition. |
| PubMedID- 24617917 | Drugs include pasireotide (indicated for cd), mifepristone (indicated to control hyperglycemia secondary to hypercortisolism in patients with cushing's syndrome) as well as several off-label treatments (ketoconazole, cabergoline, mitotane). |
| PubMedID- 23594250 | Chronic exposure to endogenous hypercortisolism in cushing's syndrome (cs) is associated with negative effects on memory and hippocampal volumes, even after biochemical cure. |
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