eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | conn syndrome |
| Comorbidity | C0020538|hypertension |
| Sentences | 24 |
| PubMedID- 25907736 | Recurrent gain of function mutation in calcium channel cacna1h causes early-onset hypertension with primary aldosteronism. |
| PubMedID- 24133375 | While the finding of primary aldosteronism in patients with resistant hypertension is in the order of 20%, such patients respond to mr antagonists no differently from the remainder without elevated aldosterone levels, suggesting that mr activation may be equally important in patients with and without an established diagnosis of primary aldosterone. |
| PubMedID- 21234416 | Particularly in patients with resistant hypertension, the prevalence of primary aldosteronism has been found between 10% and 20% [3, 39, 40]. |
| PubMedID- 24864141 | primary aldosteronism represents major cause of secondary hypertension, strongly associated with high cardiovascular morbidity and mortality. |
| PubMedID- 24285684 | Context: the molecular mechanisms of primary aldosteronism, a common cause of human hypertension, are unknown, but alterations of k(+) channels can play a key role. |
| PubMedID- 26273475 | We describe a young male patient with longstanding hypertension, who was diagnosed with primary hyperaldosteronism and treated by an attempted retroperitoneoscopic total unilateral adrenalectomy for a left-sided presumed aldosterone-secreting adenoma. |
| PubMedID- 25336886 | Description of the case: we describe a case of a 71-year-old female patient with uncontrollable hypertensive peaks in soils of pre-existing arterial hypertension, who was diagnosed with primary aldosteronism. |
| PubMedID- 21451421 | We compared the efficacy, safety and tolerability of eplerenone versus spironolactone in patients with hypertension associated with primary aldosteronism. |
| PubMedID- 23102075 | The main determinants of surgical cure or control of hypertension in patients with primary hyperaldosteronism were duration of hypertension, number of antihypertensive medications, preoperative response to spironolactone, the presence of adenoma, and cyp11b2 (344 c/t) genotype. |
| PubMedID- 24831672 | This nomogram can help clinicians calculate the probability of postoperative hypertension cure in patients with primary aldosteronism and objectively inform them of their hypertension outcome before laparoscopic adrenalectomy. |
| PubMedID- 20508722 | Furthermore we showed that hemin improved insulin-signaling/glucose metabolism in deoxycorticosterone-acetate (doca) hypertension, a model of primary aldosteronism [48], suggesting a role of the ho system against dysfunctional glucose metabolism in aldosteronism. |
| PubMedID- 21785705 | Prevalence of resistant hypertension in patients with primary hyperaldosteronism is 17–22%, higher than in the general hypertensive population. |
| PubMedID- 22311906 | Chronic aldosterone administration increases glomerular filtration rate, whereas inhibition of mineralocorticoid receptors (mrs) markedly attenuates glomerular hyperfiltration and hypertension associated with primary aldosteronism or obesity. |
| PubMedID- 23635457 | [the prevalence of hypertension after adrenalectomy in patients with primary aldosteronism]. |
| PubMedID- 26574803 | primary aldosteronism is the cause of hypertension in 5-10% of the hypertensive population. |
| PubMedID- 23470690 | One common cause of secondary hypertension, often associated with hypokalemia, is primary hyperaldosteronism or conn syndrome. |
| PubMedID- 21822477 | They point out that the incidence of primary aldosteronism in patients with drug resistant hypertension is 14% to 23%, which is much higher than in the general hypertensive population. |
| PubMedID- 24944753 | Management of hypertension in primary aldosteronism. |
| PubMedID- 26074961 | hypertension due to primary aldosteronism had long been considered a form of disease associated with a relatively low incidence of cardiovascular and renal complications [6, 7]. |
| PubMedID- 23808747 | [primary hyperaldosteronism: common cause of secondary hypertension with higher cardiovascular risk]. |
| PubMedID- 22026274 | [clear cell carcinoma of the kidney and conn's syndrome in a patient with arterial hypertension--a case report]. |
| PubMedID- 22739770 | 22-year-old patient with malignant hypertension associated with primary aldosteronism. |
| PubMedID- 25546991 | [difficulty in diagnosis of primary hyperaldosteronism as the cause of resistant hypertension and severe hypokalemia--case report]. |
| PubMedID- 24006040 | Prevalence of and risk factors for primary aldosteronism among patients with resistant hypertension in china. |
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