eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | chronic myeloproliferative disease |
| Comorbidity | C0001815|primary myelofibrosis |
| Sentences | 7 |
| PubMedID- 25486953 | primary myelofibrosis is one of the philadelphia chromosome-negative myeloproliferative neoplasms and is the member of that group with the worst survival and the most significant limitations in quality of life. |
| PubMedID- 26358171 | Context: primary myelofibrosis is one of the chronic myeloproliferative disorders characterized by bone marrow fibrosis associated with extramedullary hematopoiesis and osteosclerosis. |
| PubMedID- 20571018 | primary myelofibrosis is the rarest of the myeloproliferative neoplasms, is the most obscure with regard to its pathophysiology, and carries the least favorable although highly variable natural history. |
| PubMedID- 24091929 | primary myelofibrosis is a member of the myeloproliferative neoplasms, a diverse group of bone marrow malignancies. |
| PubMedID- 20801055 | We have studied tgfbeta1 levels in philadelphia-negative (ph-) myeloproliferative diseases, evaluating patients with primary myelofibrosis (pmf) that is characterized by increased numbers of circulating progenitor cells and bone marrow (bm) fibrosis, and patients with polycythemia vera (pv) or essential thrombocythemia (et) that do not present bm fibrosis. |
| PubMedID- 25144224 | A gain-of-function mutation in the myeloproliferative leukemia virus (mpl) gene, which encodes the thrombopoietin receptor, has been identified in patients with essential thrombocythemia and primary myelofibrosis, subgroups of classic myeloproliferative neoplasms (mpns). |
| PubMedID- 23018876 | primary myelofibrosis is a type of chronic myeloproliferative neoplasm characterized by progressive bone marrow failure with worsening cytopenia and in a subset of patients, progression to acute leukemia. |
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