eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | chronic myelocytic leukemia |
| Comorbidity | C0879615|stromal tumor |
| Sentences | 2 |
| PubMedID- 24451733 | Positron emission tomography in patients with gi stromal tumors or genotyping of c-kit in chronic myelogenous leukemia cells can guide the use of imatinib, these scenarios represent a minority of patients. |
| PubMedID- 24348666 | It was initially proposed that the t790m mutation might prevent the proper binding of tyrosine kinase inhibitors via steric hindrance, similar to the corresponding gatekeeper mutations in bcr-abl (t315i) and kit (t670i) that confer resistance to imatinib (gleevec) in chronic myelogenous leukemia and in patients with gastrointestinal stromal tumors. |
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