eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cholangiocarcinoma |
| Comorbidity | C0023895|liver disease |
| Sentences | 7 |
| PubMedID- 24867389 | In spite of a relatively high prevalence of egfr overexpression detected by immunohistochemistry (35.4% of cases with 2+ or 3+), only two cases had egfr mutations and three had gene amplification, confirming the low prevalence reported in the literature in cholangiocarcinomas unassociated with chronic liver disease [14, 38, 41-44]. |
| PubMedID- 24186137 | Intrahepatic cholangiocarcinomas with chronic advanced liver disease showed higher egfr mutation rate (5/38, 13.2% vs 1/43, 2.3%) and lower mutation rates of kras (3/38, 7.9% vs 8/43, 18.6%), mlh1 (2/38, 5.3% vs 5/43, 11.6%), and gnas (1/38, 2.6% vs 5/43, 11.6%), compared with those in intrahepatic cholangiocarcinomas with normal liver. |
| PubMedID- 20716803 | Our results suggest that intracytoplasmic hyaline bodies occasionally can be found in cholangiocarcinoma with chronic liver disease related to viral hepatitis or alcoholic intake. |
| PubMedID- 26070500 | Methods: topics discussed included the role of gadoxetic acid-enhanced mri in the differentiation of focal nodular hyperplasia from hepatocellular adenoma and small hepatocellular carcinoma (hcc) from small intrahepatic cholangiocarcinoma (in patients with chronic liver disease), the differentiation of low-grade dysplastic nodule (dn) from pre-malignant high-grade dn and early hcc, and treatment planning and assessment of treatment response for patients with hcc and colorectal liver metastasis. |
| PubMedID- 23247798 | Background: primary sclerosing cholangitis (psc) is a chronic cholestatic liver disease leading to cirrhosis and cholangiocellular carcinoma. |
| PubMedID- 24043967 | There was no clinical or biochemical evidence of chronic liver diseases in patients with cholangiocarcinomas or metastatic hepatic tumors. |
| PubMedID- 24459650 | Based on these ct findings in addition to the increased level of ca19-9, the initial tentative diagnosis was a hepatic malignant tumor such as hcc or mass-forming cholangiocarcinoma with underlying alcoholic liver disease and intrahepatic cholangitis. |
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