eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cholangiocarcinoma |
| Comorbidity | C0011847|diabetes |
| Sentences | 3 |
| PubMedID- 26557943 | Studies were included if they reported odds ratios (or) and corresponding 95% ci of cholangiocarcinoma with respect to diabetes mellitus. |
| PubMedID- 25555821 | Of those, only six (22%) did not have substantial heterogeneity (i(2)>75%), pertaining to associations between type 2 diabetes and risk of developing breast, cholangiocarcinoma (both intrahepatic and extrahepatic), colorectal, endometrial, and gallbladder cancer. |
| PubMedID- 25980580 | Although we acknowledge that the current study does not address the efficacy of metformin against cancer cell models naturally bearing clinically relevant idh1 mutations, our findings provide a direct mechanistic link to the association between metformin use and a significant reduction in incidence of intrahepatic cholangiocarcinoma (ihcc) in patients with diabetes [87]. |
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