eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cardiomyopathy |
| Comorbidity | C0042373|vascular disease |
| Sentences | 1 |
| PubMedID- 26056441 | Tissue damage occurs in many diseases, including diabetes, acute graft-versus-host disease, and cardiovascular disease.1 of these diseases, myocardial infarction, one of the leading causes of mortality, is the most common and difficult to treat in the clinic, because cardiomyocytes are not able to regenerate.2 tissue regeneration through stem/progenitor cells has been studied extensively in a wide range of tissue repair applications, especially for regeneration of cardiomyocytes, owing to the unique pluripotency and regenerative properties of these cells.3,4 however, tissue regeneration involves a series of biological processes, including mobilization of stem cells, angiogenesis, and synthesis of extracellular matrix.5,6 various cytokines are essential for homing, proliferation, and differentiation of stem/progenitor cells in the process of tissue regeneration.7,8 cytokines have been widely studied in tissue regeneration, but their short half-lives and the low local concentrations render their application limited.9,10 therefore, a reliable delivery system able to localize cytokines to specific tissues for an extended period of time and maintain their bioactivity could improve the homing, differentiation, and proliferation of stem/progenitor cells at their target tissue. |
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