eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | cardiomyopathy |
| Comorbidity | C0028754|obesity |
| Sentences | 9 |
| PubMedID- 25004087 | Indeed, coronary microvascular abnormalities have been recognized in patients suffering acute myocardial infarction, chronic stable angina and cardiomyopathies, and also in patients with hypertension, obesity and diabetes. |
| PubMedID- 23196711 | obesity-related diabetes mellitus leads to lipotoxic cardiomyopathy resulting in a form of cardiac dysfunction. |
| PubMedID- 24342999 | However, the molecular mechanisms linking obesity with cardiomyopathy are probably multifactorial and depend as much on the genetics of the individual as on environmental factors such as circulating cytokines and chemokines. |
| PubMedID- 24614171 | Many studies have shown that mitochondrial biogenesis and function are impaired in lipotoxic cardiomyopathy associated with obesity and diabetes [23], and that mitochondrial dysfunction is linked to cardiac dysfunction [24]. |
| PubMedID- 23978095 | The role of obesity in cardiomyopathy and nephropathy. |
| PubMedID- 22465089 | The cardiomyopathy seen with obesity is associated with increased interstitial fibrosis and diastolic dysfunction. |
| PubMedID- 25018087 | obesity-induced cardiomyopathy may be mediated by alterations in multiple signaling cascades involved in glucose and lipid metabolism. |
| PubMedID- 23508767 | Diabetes and obesity are both associated with lipotoxic cardiomyopathy exclusive of coronary artery disease and hypertension. |
| PubMedID- 23817015 | Background: although obesity increases the risk of developing cardiomyopathy, the mechanisms underlying the development of this cardiomyopathy are incompletely understood. |
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