eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | c syndrome |
| Comorbidity | C0001622|hypercortisolism |
| Sentences | 3 |
| PubMedID- 22321826 | This has been partially prompted not only by the striking clinical resemblances between the metabolic syndrome and cushing's syndrome (a state characterized by hypercortisolism that associates with metabolic syndrome components) but also from monogenic rodent models for the metabolic syndrome (e.g. |
| PubMedID- 21197856 | Some of the health ailments associated with hypercortisolism include metabolic syndrome, decreases in bone mineral density, and depression. |
| PubMedID- 22612409 | The usual diagnostic procedures for investigating endogenous hypercortisolism in patients with cushing's syndrome can be applied in obese dysmetabolic patients, although their sensitivity and specificity seem to be significantly reduced when dealing with subtle abnormalities of cortisol homeostasis.38 with these limitations, a series of studies performed in either epidemiological or clinical settings have investigated acth and cortisol concentrations in basal conditions—with repeated measurements to investigate daily chronobiological changes, during dynamic studies following stimulation with different neuropeptides or psychological stress tests, or by suppression with dexamethasone—to challenge the responsiveness to the inhibitory feedback system.34 in addition, there are studies evaluating glucocorticoid receptor density in different tissues, including adipose tissue. |
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