eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | brain cancer |
| Comorbidity | C0153633|malignant brain tumor |
| Sentences | 108 |
| PubMedID- 25971279 | Astrocytic tumors are the most common primary malignant brain tumors in adults [1]. |
| PubMedID- 21584215 | Out of 432 cases, 43 (non-pesticide) primary malignant brain tumors were not associated in any way with orchards or pesticides. |
| PubMedID- 24860813 | Gbm is the most aggressive primary malignant brain tumor in humans with a 5-year survival rate under 5% and median overall survival of only 12–14 months [1]. |
| PubMedID- 21181233 | High-grade gliomas, glioblastoma (gbm) and anaplastic astrocytoma (aa), are the most common and most malignant brain tumors in adults. |
| PubMedID- 22984561 | Medulloblastoma, the most common malignant brain tumor in childhood [1], are neuro-epithelial tumors arising from neural stem cell precursors in the granular cell layer of the cerebellum [2]. |
| PubMedID- 25596739 | Also medulloblastoma, the most common malignant brain tumor in children, is characterized by high levels of akt phosphorylation and activated pi3k signalling in medulloblastoma is associated with enhanced cellular motility, survival and chemoresistency underscoring its role of as a potential therapeutic target. |
| PubMedID- 25763821 | malignant brain tumor is one of the most lethal cancers in adults. |
| PubMedID- 22870228 | Glioblastoma multiforme (gbm) is the most common primary malignant brain tumor in adults. |
| PubMedID- 25571951 | Medulloblastoma, an embryonic neuroepithelial tumor of the cerebellum, is the most common type of malignant brain tumor in children and among childhood central nervous system tumors, medulloblastoma has high cancer-associated mortality (1). |
| PubMedID- 25921812 | Glioblastoma (gbm) is the most common primary malignant brain tumor in adults. |
| PubMedID- 24723567 | Diffuse gliomas are the most common group of primary malignant brain tumors.1 family history is an important risk factor for glioma, with first-degree relatives of glioma patients having an increased risk of developing the disease.2–4 although a small percentage of these families with glioma are attributed to hereditary genetic disorders such as neurofibromatosis types i and ii, li-fraumeni syndrome, and turcot's syndrome,5,6 the genes underlying the appearance of multiple gliomas in most families remain ill defined. |
| PubMedID- 21454908 | The short time period for which data on nonmalignant brain tumors are available in the united states precluded analysis of temporal trends. |
| PubMedID- 24793313 | Glioblastomas (gbms) are the most common primary malignant brain tumors in adults6. |
| PubMedID- 21209724 | They found that a majority of mice developed malignant brain tumors and that the same mutant p53 was detected in the tumor cells but not in normal cells. |
| PubMedID- 24754873 | Gbm is the most common primary malignant brain tumor in geriatric population [1]. |
| PubMedID- 25206588 | malignant brain tumors, such as glioblastoma, anaplatic astrocytoma, are challenges for neurosurgeons in the 21st century. |
| PubMedID- 24386117 | Glioblastoma multiform (gbm) is the most frequent primary malignant brain tumor in adults. |
| PubMedID- 25871397 | Glioblastoma (gbm) is the most common primary malignant brain tumor in adults, with a median survival of approximately 14 months after diagnosis [1]. |
| PubMedID- 21603237 | malignant brain tumors are characterized by an increase in glucose consumption and the relationship between histological features and radiotracer uptake is well established [28, 29]. |
| PubMedID- 22619524 | Most malignant brain tumors in adults are glioblastoma multiforme (gbm).15 gbm is a highly invasive tumor originating from glial cells with indistinct borders along the normal parenchyma, and is difficult to remove by surgical excision. |
| PubMedID- 22973314 | The association of mif with the progression of malignant brain tumors places this cytokine in center stage [100, 101]. |
| PubMedID- 24212792 | Among all human cancers, primary malignant brain tumors are one of the most challenging scientific and clinical problems in modern medicine. |
| PubMedID- 26000059 | Gliomas are the most common malignant brain tumors, characterized by extensive, diffuse infiltrative growth into the surrounding brain parenchyma and different degrees of neovascularization 14-16. according to who, gliomas are classified to four grades, with grades i-ii being low-grade glioma (lgg), and grades iii-iv being high-grade glioma (hgg) 17. however, the diagnostic accuracy of the most commonly used 18f-fdg is confounded by high physiologic glucose metabolism in the brain area, which significantly limits the sensitivity for glioma detection and the specificity for border demarcation 18. therefore, more specific radiotracers for pet to assess glioma are highly desirable. |
| PubMedID- 24260384 | Glioblastoma (world health organization/who grade iv) is the most common and aggressive type of primary malignant brain tumor in adults, killing nearly every patient within two years. |
| PubMedID- 21708977 | Mir669a is encoded by the sfmbt2 (scm-like with four malignant brain tumor domains 2) gene, a member of polycomb group proteins involved in epigenetic silencing of skeletal muscle genes (wu et al., 2007). |
| PubMedID- 21547495 | Conversely, a survival analysis of children with primary malignant brain tumors in england and wales found no regional differences [24]. |
| PubMedID- 23988086 | Glioblastoma (gbm, who grade iv glioma) is the most malignant brain tumor in adults. |
| PubMedID- 24147027 | Survival for adults with the malignant brain tumor, glioblastoma multiforme (gbm), remains poor despite decades of advancements in surgery, radiation, and chemotherapy. |
| PubMedID- 24303074 | Glioma is one of the most common malignant brain tumors in adults. |
| PubMedID- 25853389 | Medulloblastomas (mb) are the most frequent malignant brain tumors in children, with approximately 60 and 300 newly diagnosed cases per year in germany and the us, respectively [1]. |
| PubMedID- 22699553 | Among these, astrocytoma grade iv (glioblastoma multiforme, gbm), is the most common malignant brain tumor in adults and is one of the deadliest cancers. |
| PubMedID- 24714627 | Approximately 70% of malignant brain tumor patients receive dexamethasone treatment while they undergo multimodal radio-chemotherapy and a significant decrease in deaths has been related to this treatment [14]. |
| PubMedID- 21445277 | It is anticipated that the developed formulation may improve on targeted therapy for malignant brain tumors in the future. |
| PubMedID- 25736470 | Medulloblastoma is the most frequently diagnosed malignant brain tumor in children, with a peak incidence at the age of 5 years [1]. |
| PubMedID- 23852775 | Medulloblastoma is the most frequent malignant brain tumor in children accounting for about 10% of the mortality in pediatric cancer patients.1 the introduction of multimodal treatment concepts including surgery, local irradiation, and high-dose chemotherapy according to risk group and therapy response has improved the outcome of high-risk medulloblastoma patients. |
| PubMedID- 21829433 | Glioblastoma (gbm) is the most common primary malignant brain tumor in adults, and optimal surgical and medical management of this disease result in a mean survival of only 12–14 months [1], [2], [3], [4], [5]. |
| PubMedID- 24252135 | Glioblastoma multiforme (gbm) is the most frequent primary malignant brain tumor in adults [1,2]. |
| PubMedID- 24202333 | malignant brain tumors take advantage of this situation since tumor-associated macrophages were shown to infiltrate the tumor in order to enhance gbm cells’ invasion by degrading the extracellular matrix. |
| PubMedID- 22737605 | Glioblastoma multiforme (gbm) is the most common malignant brain tumor in adult patients. |
| PubMedID- 25722935 | Malignant gliomas (mgs) are the most common type of primary malignant brain tumor in the adult population, comprising up to 80% of all cases. |
| PubMedID- 25789324 | Glioblastoma multiforme (gbm) is the most common malignant brain tumor in adults and accounts for 17% of intracranial tumors [1]. |
| PubMedID- 20016537 | One patient experienced a smn as a first event (malignant brain tumor in a previously irradiated patient) and two others were diagnosed with meningiomas (both previously irradiated). |
| PubMedID- 25528767 | These highly heterogeneous malignant brain tumors, usually found only in children, have been classified into six molecular subgroups, each with a unique combination of chromosomal aberrations [23]. |
| PubMedID- 22390279 | Medulloblastoma is the most common malignant brain tumor in children. |
| PubMedID- 20963628 | Primary malignant brain tumors are a significant therapeutic challenge in spite of substantial advances in tumor imaging, neurosurgery, and radiation therapy. |
| PubMedID- 25879388 | These highly aggressive tumors are among the most frequently diagnosed malignant brain tumors in children. |
| PubMedID- 24174164 | While this tumor comprises the most common malignant brain tumor in children, it only accounts for approximately 1 % of primary cns tumors in adults [18, 20]. |
| PubMedID- 23225805 | Glioblastoma (gbm) is the most common primary malignant brain tumor in adults. |
| PubMedID- 22275880 | Medulloblastoma, one of the more common malignant brain tumors in children which originates in the area between the brainstem and the cerebellum, remains responsible for a significant level of morbidity and mortality among cancer patients. |
| PubMedID- 26425604 | Medulloblastomas are most common malignant brain tumors of the pediatric population, typically arising in the cerebellum. |