eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | biliary cirrhosis, primary, 1 |
| Comorbidity | C0008370|bile duct obstruction |
| Sentences | 1 |
| PubMedID- 26357635 | Main complications are irregular bile duct obstruction, development of secondary biliary cirrhosis, and cholangiocarcinoma.36 pathogenesis of psc is incompletely understood, but this entity has been described as an immune-mediated phenomenon triggered by environmental factors in genetically susceptible individuals.37 the perfect animal model that summarizes all the attributes of psc (cholangitis of the intra- and extra-hepatic bile ducts in association with gut inflammation and development of cholangiocarcinoma and/or secondary biliary cirrhosis) and exhibits a male predominance does not exist. |
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