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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease b-cell chronic lymphocytic leukemia
Comorbidity C0023448|lymphocytic leukemia
Sentences 3
PubMedID- 20637437 Here, we report a case of low-grade b-cell leukemia most consistent with chronic lymphocytic leukemia/small lymphocytic lymphoma that displayed numerous intracytoplasmic, needle-shaped, azurophilic rods resembling auer rods.
PubMedID- 22897733 The impact of initial fludarabine therapy on transformation to richter syndrome (rs) or prolymphocytic leukemia (pll) in patients with chronic lymphocytic leukemia (cll) is uncertain.
PubMedID- 20842105 In chronic lymphocytic leukemia (cll), overexpression of antiapoptotic b-cell leukemia/lymphoma 2 (bcl-2) family members contributes to leukemogenesis by interfering with apoptosis; bcl-2 expression also impairs vesicular stomatitis virus (vsv)-mediated oncolysis of primary cll cells.

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