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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease autosomal dominant polycystic kidney disease
Comorbidity C0020538|hypertension
Sentences 22
PubMedID- 25030010 Sympathetic overactivity plays a crucial role in the genesis and aggravation of arterial hypertension in patients with autosomal dominant polycystic kidney disease (adpkd).
PubMedID- 20219618 hypertension in autosomal dominant polycystic kidney disease.
PubMedID- 24463189 Whether hypertension in adpkd is a primary vasculopathy secondary to mutations in the polycystin genes or secondary to activation of the renin-angiotensin-aldosterone system by cyst expansion and intrarenal ischemia is unclear.
PubMedID- 22902029 Purpose: cyst proliferation in patients with autosomal dominant polycystic kidney disease is associated with renal failure, hypertension and pain.
PubMedID- 20429898 Even microalbuminuric adpkd patients with hypertension have a significantly higher filtration fraction and larger renal volumes [1].
PubMedID- 26254120 Pheochromocytoma as a rare cause of arterial hypertension in a patient with autosomal dominant polycystic kidney disease: a diagnostic and therapeutic dilemma.
PubMedID- 23971639 Therapy of hypertension in autosomal dominant polycystic kidney disease with angiotensin-converting enzyme inhibitors or angiotensin receptor blocker has the potential to prevent cardiovascular complications and slow the progression of renal disease.
PubMedID- 25364490 hypertension in autosomal dominant polycystic kidney disease: a clinical and basic science perspective.
PubMedID- 24429399 The complex mechanisms that underlie pathogenesis of hypertension in adpkd are incompletely understood.11 it is still debated whether adpkd-related sah is primarily caused by vascular/endothelial abnormalities or depends on renal cyst formation and expansion.
PubMedID- 23808746 hypertension in adpkd leads to early development of left ventricle hypertrophy and definitely contributes to the progression of chronic renal insufficiency.
PubMedID- 24621146 Renal sympathetic-nerve ablation for uncontrolled hypertension in a patient with single-kidney autosomal dominant polycystic kidney disease.
PubMedID- 23971640 hypertension in children with autosomal dominant polycystic kidney disease (adpkd).
PubMedID- 21234092 hypertension in adpkd occurs before the loss of kidney function in 60% of affected individuals and increases to almost 100% in patients with ckd stage iv-v [39, 40].
PubMedID- 21206683 He was recently detected to have adpkd with hypertension and eskd, and was on conservative management.
PubMedID- 22791703 Several mechanisms can cause hypertension in adpkd patients, although, primary aldosteronism (pa) as a possible manifestation of hypertension in adpkd is extremely rare.
PubMedID- 21694639 Congenital hepatic fibrosis and portal hypertension in autosomal dominant polycystic kidney disease.
PubMedID- 20150584 Refractory ascites due to portal hypertension in autosomal dominant polycystic kidney disease (adpkd) patients successfully treated with peritoneal dialysis.
PubMedID- 25922609 hypertension in adpkd patients is an early identifiable marker of renal disease and cardiovascular disease [1,12,14].
PubMedID- 26418387 The pathogenesis of hypertension in adpkd is complex and depends on many factors that influence each other.
PubMedID- 23988725 Methods: eighty-four adpkd patients (43 with hypertension and 41 without hypertension) and 40 healthy controls were studied cross-sectionally.
PubMedID- 23121377 Background: the course of autosomal dominant polycystic kidney disease (adpkd) is often associated with pain, hypertension, and kidney failure.
PubMedID- 21292815 Methods: fifty-two adpkd patients with hypertension and estimated glomerular filtration rate (egfr) <60 ml/min/1.73 m(2), 50 adpkd patients with hypertension and egfr >/= 60 ml/min/1.73 m(2), 42 normotensive adpkd patients with egfr >/= 60 ml/min/1.73 m(2) and 51 normotensive healthy controls were enrolled in this study.

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