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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease antiphospholipid syndrome
Comorbidity C0000786|miscarriage
Sentences 5
PubMedID- 24040195 In women with recurrent miscarriage and a diagnosis of antiphospholipid syndrome (aps), treatment with aspirin and heparin has been suggested to improve the pregnancy outcome, although findings from available randomized trials have been inconsistent [11], [12], [13].
PubMedID- 20393166 Antiphospholipid antibodies (apl) represent an important risk factor for thrombosis and recurrent miscarriage in patients with antiphospholipid syndrome (aps).
PubMedID- 20795446 This retrospective review of hospital records analysed pregnancy outcome with 2 different treatments for women with recurrent miscarriage diagnosed with antiphospholipid syndrome in the index pregnancy.
PubMedID- 20378110 antiphospholipid syndrome patients with recurrent miscarriage have an impairment in fibrinolysis demonstrated by prolonged clot lysis time (clt) that cannot be attributed to differences in thrombin activatable fibrinolysis inhibitor (tafi) antigen levels.
PubMedID- 21792337 Small-scale trials investigating the use of aspirin in the prevention of recurrent miscarriage in women without antiphospholipid syndrome have so far found little benefit;88 however, the findings regarding aggregation response to arachidonic acid lend support to reevaluating the benefit of aspirin in larger trials with a clearly defined cohort of individuals with recurrent miscarriage.

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