eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | american trypanosomiasis |
| Comorbidity | C0041234|chagas disease |
| Sentences | 1 |
| PubMedID- 24136392 | Our data from this study and other reports suggest that a pro‐oxidant milieu, evidenced by increased ros and glutathione disulfide (gssg) levels and lipid and protein oxidation products, is present in the myocardium in chronic chagas disease.5,8,12,33 treatment of t cruzi–infected animals with an antioxidant resulted in a significant decline in myocardial oxidative adducts concurrent with preservation of a cardiac hemodynamic state that otherwise was compromised in the chronic disease phase in infected rats.11,13 a decline in oxidative stress in human chagas disease patients given vitamin a has also been shown.34 these observations have supported the idea that the sustained oxidative stress is of pathological importance in chagasic cardiomyopathy, although the source of oxidative stress was unclear. |
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