eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | alpha-1-antitrypsin deficiency |
| Comorbidity | C0282193|iron overload |
| Sentences | 2 |
| PubMedID- 26310624 | Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease. |
| PubMedID- 24024049 | Many chronic liver diseases such as nonalcoholic fatty liver disease (nafld), chronic hepatitides b and c, pbc, and alpha-1 antitrypsin deficiency are associated with mild iron overload with near-normal transferrin saturation rarely exceeding 45% (the threshold fasting transferrin saturation to initiate further hemochromatosis work-up) [3, 4]. |
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