eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | adenomatous polyposis coli |
| Comorbidity | C0032580|adenomatous polyposis |
| Sentences | 7 |
| PubMedID- 21765995 | Epigenetic gatekeepers such as cyclin-dependent kinase inhibitor 2a (cdkn2a/p16), secreted frizzled-related protein (sfrp), gata-binding protein 4 and 5 (gata-4 and -5), and adenomatous polyposis of the colon (apc) prevent early tumor progression in colon cancer. |
| PubMedID- 24466159 | In colorectal cancer cells, frequent mutations are observed in apc, the responsible gene for familial adenomatous polyposis of the colon, and β-catenin (ctnnb1)[4], [7]. |
| PubMedID- PMC3518159 | The studies have encompassed over 30 families with juvenile polyposis syndrome and phts, over 40 families with peutz-jeghers syndrome and almost 600 families with familial adenomatous polyposis of the colon. |
| PubMedID- 21315632 | A 17-year-old boy with adenomatous polyposis and a history of an adenomatous polyposis coli (apc) gene mutation (ivs13(-2) a>g) presented for evaluation of vertical, binocular diplopia. |
| PubMedID- 22908982 | In addition, the founder mutations leading to adenomatous polyposis of the colon and the hepatocerebral mitochondrial dna depletion syndrome are reported on the same haplotypes only among tunisian and moroccan patients [41,42]. |
| PubMedID- 22120905 | Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis. |
| PubMedID- 23519466 | Fap1 also interacts with the adenomatous polyposis coli (apc) protein, but the functional significance of this interaction is unknown. |
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