eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | adenocarcinoma of esophagus |
| Comorbidity | C0017168|gastro-oesophageal reflux |
| Sentences | 3 |
| PubMedID- 20955441 | Meta-analysis: the association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux. |
| PubMedID- 24282412 | Progression from healthy tissue to premalignant barrett's oesophagus (bo) and further to malignant oesophageal adenocarcinoma (oac) is associated with gastro-oesophageal reflux, leading to ros accumulation and increased oxidative dna damage. |
| PubMedID- 24243140 | Siewert and leers have previously reported 37% 2 and 50% 3 respectively from large single centre western series compared to the low prevalence of type iii tumours seen in eastern series (5.6%) 29. the proportional increase in type i tumours in our series is likely to represent the widely reported increase in incidence of oesophageal adenocarcinoma 30,31 associated with gastro-oesophageal reflux disease 32 and barrett's metaplasia 33 in the united kingdom 34. the expansion of endoscopic barrett's surveillance strategies is also likely to have increased disease detection and treatment. |
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