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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease acute liver failure
Comorbidity C0019151|hepatic encephalopathy
Sentences 22
PubMedID- 26195209 Diagnosis and management of hepatic encephalopathy in fulminant hepatic failure.
PubMedID- 22825549 On the other hand, the disease entity of “acute hepatitis severe type” was excluded from the footnote of the present criteria, because patients classified under such a disease entity can also be diagnosed as having “acute liver failure without hepatic encephalopathy”.table 4classification of hepatic encephalopathy in adult patients according to the grade of hepatic coma proposed by the inuyama symposium in 1972; from reference [30]grade of comapsychiatric disordersreference itemsiinversion of sleep patterneuphoria and/or occasional depressionnegligent attitude with shortened attention spanrecognized retrospectively in most casesiidisorientation of time or place and confusioninappropriate behaviors, such as throwing away money or discarding items of valueoccasional somnolent tendency; able to open eyes and respond appropriately to questionsmakes impolite remarks, but follows doctors’ instructionsexcitation state and, urinary and fecal incontinence are absent, but flapping tremor is found on physical examinationiiistate of excitation and/or delirium, showing defiant behaviorsomnolent tendency; sleeping most of the timeopens eyes in response to stimulation, but cannot follow the instructions of doctors, except for simple ordersflapping tremor is observed, and the extent of disorientation is severeivcoma; complete loss of consciousnessresponse to painful stimulibrushes off doctor’s hands if touched and/or frowns in response to stimulivdeep comano response to painful stimulitable 5classification of hepatic encephalopathy in pediatric patients and infants according to the grade of hepatic coma as proposed at the 5th workshop on pediatric liver diseases in 1988; from reference [30]grade of comapediatric patientsinfantsilow-spirited from before (seems lethargic compared with previous physical activity level)does not laugh aloudiiobedient attitude with somnolent tendencydisorientation of time or placedoes not laugh even when being played withcannot maintain eye contact with the mother (more than 3 months after birth)iiiopens eyes in response to loud voiceivdoes not wake up in response to painful stimuli, but frowns and/or brushes off the item producing the stimulus with his/her handsvno response to painful stimulitable 6classification of etiologies of acute liver failure modified from the criteria proposed by the intractable liver diseases study group of japan in 2002; from reference [30]i.viral infection 1 hepatitis a virus (hav) 2 hepatitis b virus (hbv)  (1) transient infection  (2) acute exacerbation in hbv carrier   i. inactive carrier, without drug exposure   ii.
PubMedID- 24069137 In human, brain edema is a critical component of hepatic encephalopathy associated with acute liver failure [3,4].
PubMedID- 24713795 fulminant liver failure model with hepatic encephalopathy in the mouse.
PubMedID- 21423375 Brain edema is a critical component of hepatic encephalopathy associated with acute liver failure and such edema appears to be principally due to astrocyte swelling (cytotoxic edema).
PubMedID- 21372353 Patients were excluded from the study if they had nonhepatic metabolic encephalopathies, severe co morbid conditions (like severe associated lung or cardiac disease) or hepatic encephalopathy due to acute liver failure.
PubMedID- 21182490 We investigated the effects of cannabidiol, a non-psychoactive constituent of cannabis sativa with anti-inflammatory properties that activates the 5-hydroxytryptamine receptor 5-ht(1a) , on brain and liver functions in a model of hepatic encephalopathy associated with fulminant hepatic failure induced in mice by thioacetamide.
PubMedID- 24975240 Frontal electroencephalogram variables are associated with the outcome and stage of hepatic encephalopathy in acute liver failure.
PubMedID- 25999668 Moreover, cbd restored liver/brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure induced in mice revealing that its effects may result from a combination of its actions in the liver and brain [26].
PubMedID- 25537182 Erratum to: acute liver failure-induced hepatic encephalopathy is associated with changes in microrna expression profiles in cerebral cortex of the mouse.
PubMedID- 20492684 On the other hand, our experience is that serum ammonia concentration does not correlate with the degree of hepatic encephalopathy in patients with acute liver failure occasionally.
PubMedID- 24396287 In general, hav infection risk is inversely correlated to sanitation and other socio-economic indicators 21. although japan is one of the developed countries in asia, a universal vaccination program against hav and hbv has not yet been initiated 17. although the present study did not include acute liver failure with hepatic encephalopathy such as fulminant hepatitis a, our study is important because udps analysis of these hav strains reconfirmed that a single source might have caused this outbreak as previously reported 16, suggesting that udps analysis might be a new analytical tool for the source of hepatitis a outbreaks.
PubMedID- 22971971 Treatment and course: a hepatic encephalopathy due to acute hepatic failure was diagnosed and a detoxication of ammonemia with lactulose was started immediately.
PubMedID- 20673320 A head ct scan frequently demonstrates cerebral edema in acute liver failure patients with advanced-stage hepatic encephalopathy [6] but is insensitive to intracranial hypertension [7].
PubMedID- 23724918 Case presentation: a 6-year-old sri lankan girl developed acute liver failure with severe hepatic encephalopathy due to sodium valproate.
PubMedID- 24365344 fulminant hepatic failure presents with a hepatic encephalopathy and may progress to coma and often brain death from cerebral edema.
PubMedID- 20594263 Conclusions: chronic gm treatment does not have a major effect on hepatic encephalopathy in rats with taa-induced acute liver failure and rats with chronic liver failure induced by common bile duct ligation.
PubMedID- 23672352 Matrix metalloproteinase-9 as a therapeutic target for the progression of fulminant liver failure with hepatic encephalopathy: a pilot study in mice.
PubMedID- 21263362 Invasive intracranial pressure monitoring is a useful adjunct in the management of severe hepatic encephalopathy associated with pediatric acute liver failure.
PubMedID- 25896893 The long-term effects of hepatic encephalopathy in patients with acute liver failure have not been widely examined but those who recover are largely neurologically intact.
PubMedID- 22219576 He was diagnosed to be a case of acute hepatic failure with stage iv hepatic encephalopathy.
PubMedID- 24861182 acute liver failure-induced hepatic encephalopathy s associated with changes in microrna expression rofiles in cerebral cortex of the mouse [corrected].

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