eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | acromegaly |
| Comorbidity | C0018799|heart disease |
| Sentences | 1 |
| PubMedID- 24272033 | Regarding dyslipidemia, statin therapy has been shown to provide significant improvements in atherogenic lipid profile and reduce calculated coronary heart disease risk in patients with acromegaly [48].case study: addressing multiple comorbidities in a patient with acromegaly (lucio vilar, md, phd)a 40 year-old female was referred to the endocrinologist in april 2008 due to amenorrhea over the previous 10 monthssymptoms increased shoe size (from 35 to 38) oily skin, excessive sweating excessive snoring amenorrhea (10 months) polyarthralgiasigns height: 1.56 m weight: 66.3 kg blood pressure (bp): 160/100 mmhg enlarged hands and feet macroglossia, diastema prognathism, dental malocclusion no goiterpersonal and family history no family history of diabetes, cancer, thyroid disease or pituitary disease the last medical evaluation was made in 2004; no biochemical abnormality was foundlab tests gh (icma): 23.8 μg/l igf-1 (icma): 960 μg/l (normal 101–267 μg/l) gh nadir during ogtt: 6.3 μg/l prolactin and thyroid function tests: normal estradiol: 46 pmol/l (12.6 pg/ml) fsh: 0.8 iu/l fasting plasma glucose: 7.6 mmol/l (137 mg/dl) hba1c = 7.4 % serum calcium: normal triglycerides: 5.5 mmol/l (487 mg/dl) hdl cholesterol: 0.8 mmol/l (31 mg/dl)diagnosis acromegaly caused by a gh-secreting pituitary macroadenomamri macroadenoma (2.3 × 1.8 cm), with infrasellar, parasellar and suprasellar extension (fig. |
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