eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | acrocephalosyndactyly |
| Comorbidity | C0524851|neurodegenerative disease |
| Sentences | 1 |
| PubMedID- 25056147 | In the presentreport, we have demonstrated preliminary supportfor our enamide strategy through reaction with and detection of theactivity of a specific class of enzymes, the histone deacetylases(hdacs).16 hdacs regulate the level ofε-amino acetylation of histone lysine residues, thereby controllingtranscriptional regulation via chromatin remodeling.16−20 published reports indicate that irregular transcription resultingfrom altered expression levels of hdacs is associated with cancer,neurodegenerative diseases, and psychiatric conditions, making hdacsimportant drug targets for these diseases.21−30 to detect hdac deacetylation, we used an enamide bearing an n-acetyl group, which forms an aldehyde following deacetylation,thus leading to intracellular accumulation (figure 1). |
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