eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | acrocephalosyndactyly |
| Comorbidity | C0032302|mycoplasma pneumonia |
| Sentences | 1 |
| PubMedID- 21869914 | One of the most important atypical causative agent of acs in patients with scd is mycoplasma pneumoniae, which is particularly common in young children.72 mycoplasma infection can be complicated by the development of complement fixing igm anti-i cold reacting red cell auto-antibodies that can cause agglutination and haemolysis in the colder peripheral parts of the body.73 more over, in rare cases mycoplasma infection maybe associated with warm igg red cell auto-antibodies that can cause agglutination and haemolysis even at core body temperature of 37°c.74 therefore, scd patients who develop acs due to mycoplasma are at risk of developing increased haemolysis if the infection is associated with red cell auto-antibodies.73 we infer that auto-agglutination in patients with scd will also produce large red cell aggregates that would predictably result in increased blood viscosity, stasis and impairment of blood flow leading to increased production of deoxy-hbs, red cell sickling and voc. |
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