eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | abdominal aortic aneurysm |
| Comorbidity | C0020456|hyperglycemia |
| Sentences | 1 |
| PubMedID- 23130125 | In mice with experimentally induced hyperglycemia, the expansion rate of abdominal aortic aneurysms was significantly attenuated.11 in clinical studies, diabetes was found to be associated with a reduced prevalence and expansion rate of abdominal aortic aneurysms, and this was correlated with decreased secretion of metalloproteinases by aortic inflammatory cells from diabetic patients.12,28 hyperglycemia is also associated with reduced adventitial neovascularization and decreased infiltration of inflammatory cells into the medial layer of the aorta.29 these processes could also inhibit the progression of taad by reduction of vascular smooth muscle cell death and extracellular matrix degradation. |
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