eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | metabolic syndrome x |
| Comorbidity | |obesity |
| Sentences | 300 |
| PubMedID- 26291691 | obesity is strongly associated with metabolic syndrome. |
| PubMedID- 25888859 | Nash is considered the hepatic manifestation of the metabolic syndrome and is associated with central obesity, insulin resistance, diabetes, essential hypertension, and dyslipidemia [17,18]. |
| PubMedID- 24816278 | Hepatic manifestations of the metabolic syndrome (hmms) are associated with obesity, type 2 diabetes/insulin resistance, non-alcoholic fatty liver disease (nafld), and progression to non-alcoholic steatohepatitis (nash) [1]. |
| PubMedID- 21351667 | obesity is a part of the metabolic syndrome and an independent mortality risk factor in all age categories, however, this relation is twice as strong in individuals under fifty years of age. |
| PubMedID- 25603918 | These include obesity, a component of the ‘metabolic syndrome’,7 and reduced bone mineralisation that can result in frank osteoporosis8; both disorders contribute to diminished physical activity and carrying the burden of morbidity and mortality. |
| PubMedID- 21518436 | obesity, which is associated with the metabolic syndrome, is an independent risk factor for stroke in adults [4,5]. |
| PubMedID- 24217719 | Myocardial infarction and ischemic heart disease in overweight and obesity with and without metabolic syndrome. |
| PubMedID- 21219375 | Visceral obesity, a pivotal characteristic of the metabolic syndrome, suppresses the hypothalamic-pituitary-testicular axis leading to diminished testosterone production. |
| PubMedID- 25916862 | Renin-angiotensin-aldosterone system (raas) inhibition with an ace or an arb and treatment with calcium channel blockers appears safe and well tolerated in obesity-related hypertension and in patients with metabolic syndrome. |
| PubMedID- 25672777 | metabolic syndrome (mets) is associated with abdominal obesity, hyperlipidemia, insulin resistance, and type 2 diabetes mellitus, and increases the risk of cardiovascular disease. |
| PubMedID- 22814837 | Conclusions: japanese criteria of obesity in metabolic syndrome in man may be appropriate for diabetes mellitus. |
| PubMedID- 23497697 | obesity and diet-dependent development of metabolic syndrome are considered as a global health problem [1,2]. |
| PubMedID- 21250778 | Genetic variation at the cd36 loci have been associated with obesity and lipid components of the metabolic syndrome, with risk of heart disease and type 2 diabetes. |
| PubMedID- 25830228 | While metabolic syndrome is often associated with obesity, 25% of humans suffering from it are not obese and the effect of physical activity remains unclear in such cases. |
| PubMedID- 21197447 | Both cachexia and obesity with/without the metabolic syndrome (mets) represent two poles of metabolic abnormalities that are prevalent in patients with copd and are related to adverse clinical outcomes [1]. |
| PubMedID- 23819808 | Background: it has been well documented that obesity is closely associated with metabolic syndrome (mets). |
| PubMedID- 22673409 | Amh levels were not significantly related with obesity, indices of insulin resistance, and metabolic syndrome-related variables in both pcos and control groups. |
| PubMedID- 26000287 | However, eat weight in the fg group was higher than that in the st group; this result was consistent with abdominal obesity typically associated with metabolic syndrome. |
| PubMedID- 25815341 | Visceral obesity, the central core of metabolic syndrome (mets), is conceived as the pathogenic basis of an increased cardiovascular burden and is related with changes in cytokines. |
| PubMedID- 24082707 | 90. diagnosis of metabolic syndrome: abdominal obesity defined as > 35 inches in females; serum triglycerides > 150 mg/dl; bp > 130/85 mmhg; and fasting plasma glucose > 110 mg/dl. |
| PubMedID- 24830585 | obesity, an essential component of the metabolic syndrome, is also associated with increased incidence of breast, endometrial, bowel, esophagus, and kidney cancer. |
| PubMedID- 24647445 | It is well established that central obesity is the hallmark of the metabolic syndrome [3]. |
| PubMedID- 20514047 | In this regard the ability of adipose tissue to expand and match the storage needs of energy surplus may be a key determinant of the susceptibility to developing metabolic syndrome associated with obesity (1-4). |
| PubMedID- 22303323 | These have revealed a relationship between maternal obesity and the onset of the metabolic syndrome in the offspring. |
| PubMedID- 24587762 | Suggested that visceral obesity, a component of the metabolic syndrome, adversely affects endothelial function and testosterone levels, leading to hypogonadism and erectile dysfunction [23]. |
| PubMedID- 20972515 | Urbanisation is associated with obesity, hypertension and development of the metabolic syndrome (ms). |
| PubMedID- 26064845 | In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. |
| PubMedID- 20236509 | This finding is consistent with the observation that in children, obesity is strongly associated with metabolic syndrome [10,11]. |
| PubMedID- 26084279 | Chronic kidney disease among overweight and obesity with and without metabolic syndrome in an urban chinese cohort. |
| PubMedID- 23930111 | Background: obesity in accordance with metabolic syndrome (mets) confronts populations at the higher risk of morbidity and mortality of chronic diseases including, chronic kidney diseases (ckd). |
| PubMedID- 25755863 | Methods: total of 94 patients were divided into obesity with metabolic syndrome (ms) (n=30), obesity without ms (n=33), and control (n=31) groups. |
| PubMedID- 21966331 | [15] kato and colleagues [20], showed that among the components of metabolic syndrome, abdominal obesity and low hdl-c levels were more frequently observed in patients with multiple, complex coronary lesions. |
| PubMedID- 26378573 | H rats showed signs of metabolic syndrome leading to visceral obesity with hypertension, glucose intolerance, cardiovascular remodelling and nonalcoholic fatty liver disease. |
| PubMedID- 24031137 | Association of gene polymorphism of the fat mass and obesity associated gene with metabolic syndrome: a retrospective cohort study in japanese workers. |
| PubMedID- 26107367 | Objectives: the aim of this study was to evaluate the efficacy of roux-en-y gastric bypass (rygb), compared with nonsurgical treatment (ns group), as an instrument for inducing remission of co-morbidities related to metabolic syndrome (mets) in patients with obesity, grades 2 and 3 (ob2,3). |
| PubMedID- 25688280 | Secondary aims were to examine the effects on leg strength, central obesity, and other measures of metabolic syndrome. |
| PubMedID- 24829483 | The discovery that mice harboring a mutation in the core circadian gene circadian locomotor output cycles kaput (clock) develop obesity and evidence of the metabolic syndrome represented a seminal moment for the field, clearly establishing a link between circadian rhythms, energy balance, and metabolism at the genetic level. |
| PubMedID- 22998770 | However, annotated functional classifications might provide an important reference resource to understand the pathogenesis of obesity associated with the metabolic syndrome. |
| PubMedID- 20338978 | Earlier studies showed that sedentary behaviour is positively associated with coronary heart disease risk factors, obesity and development of the metabolic syndrome [37]. |
| PubMedID- 22332072 | obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases. |
| PubMedID- 25490708 | Elevated ggt can signal liver injury generally, and non-alcoholic fatty liver disease associated with abdominal obesity and other features of the metabolic syndrome [39]. |
| PubMedID- 23161371 | We have previously reported that obesity with features of metabolic syndrome (obesity, insulin-resistance, dyslipidaemia) decreases myocardial resistance to i-r compared with lean insulin-sensitive animals. |
| PubMedID- 24438079 | In order to develop and standardize a mouse model reflecting the human situation of metabolic syndrome with diet-induced obesity, adipose tissue inflammation promoting insulin resistance and atherosclerosis we investigated the effect of a common high-fat diet and a sucrose-enriched high-fat diet in ldlr-/- mice. |
| PubMedID- 21674931 | It was found that bariatric intervention fulfilled in earlier age groups would prevent the development of metabolic syndrome (ms) in patients with obesity at later date. |
| PubMedID- 22115311 | Interestingly, mice genetically deficient in tlr-5 have an altered gut microbiota composition that correlates with obesity and several features of the metabolic syndrome including hyperlipidemia, hypertension, and insulin resistance, which could at least in part be attributed to increased food consumption [59]. |
| PubMedID- 20015201 | As shown by gonzales-sanchez and coworkers the enpp1 121q allele might contribute to the genetic susceptibility to abdominal obesity among subjects with metabolic syndrome [36]. |
| PubMedID- 24306159 | Sarcopenic obesity is closely associated with metabolic syndrome. |
| PubMedID- 24170999 | In our previous study, the serum bmp-4 level was associated with obesity and the presence of metabolic syndrome [4]. |
| PubMedID- 25591987 | Taken together, it is clear that baff unites obesity with metabolic syndrome. |
| PubMedID- 24511516 | Diabetes, hyperlipidemia and obesity form the basis of the metabolic syndrome; it was shown to be an independent predictor of poor outcomes in heart transplant recipients. |