eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | c syndrome |
| Comorbidity | |obesity |
| Sentences | 307 |
| PubMedID- 24602590 | Results from baseline heart health screenings identified high obesity rates, high prevalence of metabolic syndrome, and low fruit and vegetable consumption as priority risk factors to address (16). |
| PubMedID- 23991406 | [24] confirmed that sarcopenia as well as obesity affect the development of metabolic syndrome. |
| PubMedID- 24416020 | The selective orexin receptor 1 antagonist act-335827 in a rat model of diet-induced obesity associated with metabolic syndrome. |
| PubMedID- 22447857 | Overweight characterized by inappropriate expansion of adipose cells (hypertrophic obesity) is associated with the metabolic syndrome and is caused by an inability to recruit and differentiate new precursor cells. |
| PubMedID- 21250778 | Genetic variation at the cd36 loci have been associated with obesity and lipid components of the metabolic syndrome, with risk of heart disease and type 2 diabetes. |
| PubMedID- 24816278 | Hepatic manifestations of the metabolic syndrome (hmms) are associated with obesity, type 2 diabetes/insulin resistance, non-alcoholic fatty liver disease (nafld), and progression to non-alcoholic steatohepatitis (nash) [1]. |
| PubMedID- 20927114 | Therefore, we focused on the spontaneously hypertensive corpulent rat (shr/n-cp), a model with type 2 diabetes, obesity and features of the metabolic syndrome to characterize retinal changes at a structural and functional level. |
| PubMedID- 21219375 | Visceral obesity, a pivotal characteristic of the metabolic syndrome, suppresses the hypothalamic-pituitary-testicular axis leading to diminished testosterone production. |
| PubMedID- 20230058 | When ep was given at low, medium, and high dosages (94, 188, and 470 mg/kg) to sucrose water-treated wistar rats for four weeks, alleviation of symptoms associated with metabolic syndrome, including obesity, insulin resistance, hypertriglyceridemia, and hypertension, accompanied by hepatic acc inactivation, was seen in the low dosage group. |
| PubMedID- 25586249 | obesity is associated with the metabolic syndrome. |
| PubMedID- 20180954 | It is however pertinent to note that although the specific role of central obesity in patients with the metabolic syndrome remains unexplained, active brown adipocytes which accumulate in central locations have been found to be metabolically active. |
| PubMedID- 25911907 | The presence of fatty pancreas represents a meaningful manifestation of metabolic syndrome together with obesity and hepatic steatosis. |
| PubMedID- 25833179 | Lipodystrophy diagnosis can be challenging, and it has been suggested that partial forms can be easily misdiagnosed as common central obesity with associated metabolic syndrome. |
| PubMedID- 26474291 | Next, obesity often coincides with metabolic syndrome (mets), type 2 diabetes (t2d) and chronic inflammation in varying degrees. |
| PubMedID- 25961053 | In contrast to the zdf male, the male zdsd rat maintains a moderately long period (approximately eight weeks) of prediabetic metabolic syndrome with obesity, followed by progression to overt diabetes and its complications. |
| PubMedID- 24082792 | Hypertension has been described as one of the most important factors for the development of metabolic syndrome,27,29–31 together with central obesity.27,30,31 however, the criteria for central obesity also differed among the various studies, some of which measured it according to waist circumference while others used the body mass index. |
| PubMedID- 22315154 | Aim: the aim of this study was to determine the prevalence of erectile dysfunction (ed), testosterone deficiency syndrome (tds), and metabolic syndrome in patients with abdominal obesity (ao) and the prevalence of morbidity at different levels of testosterone (tst). |
| PubMedID- 22777542 | According to skilton et al.,35 adjusting for bmi, in this case, will produce findings that address the association between macronutrient composition and the non-obesity components of the metabolic syndrome. |
| PubMedID- 21270259 | Thus, available information suggests that obesity and other facets of metabolic syndrome involve deregulation of signaling pathways mediated by ppar. |
| PubMedID- 24587762 | Suggested that visceral obesity, a component of the metabolic syndrome, adversely affects endothelial function and testosterone levels, leading to hypogonadism and erectile dysfunction [23]. |
| PubMedID- 22537054 | The numbers of positive components in metabolic syndrome between subjects with central obesity and without central obesity. |
| PubMedID- 20981493 | Lower testosterone levels were associated with central obesity- a strong component of a metabolic syndrome, and unsubstituted testosterone deficiency might be an important cardiovascular risk factor in patients with hypopituitarism. |
| PubMedID- 26064845 | In fact, insulin resistance, dyslipidemia, obesity and hypertension, each of these variables of metabolic syndrome gets influenced by the serum uric acid level. |
| PubMedID- 22691465 | Which reported that metabolic syndrome with obesity occurs in 38.7% of moderately obese and 49.7% of severely obese children and adolescents. |
| PubMedID- 25769350 | Therefore, a proanthocyanidin-rich diet during obesity can improve some of the metabolic syndrome symptoms at least at the molecular level. |
| PubMedID- 25873954 | Similar to how metabolic syndrome can be strongly associated with abdominal obesity, metabolic syndrome can also be related to lifestyle, in particular a person's diet and physical activities. |
| PubMedID- 21385419 | These findings provide important insight and implications for preventing and treating obesity associated with metabolic syndrome. |
| PubMedID- 22584415 | Some [39, 40], but not other [41, 42], authors found that plasma resistin levels positively correlate with obesity and other constituents of the metabolic syndrome. |
| PubMedID- 23714599 | Background: opinions differ over the exercise modalities that best limit cardiovascular risk (cvr) resulting from visceral obesity in individuals with metabolic syndrome (mets). |
| PubMedID- 23696677 | Some studies have suggested that the metabolic syndrome (including obesity) may be associated with dkd in type 1 diabetes. |
| PubMedID- 25679397 | Effects of metabolic syndrome with or without obesity on outcomes after coronary artery bypass graft. |
| PubMedID- 21176200 | Results from the multiple regression analysis showed that insulin resistance and obesity were associated with the metabolic syndrome. |
| PubMedID- 22905200 | The specific questions we set out to address in this report were: (1) what are the major gut microbial subpopulations in this population and how does their distribution vary in obesity and with metabolic syndrome phenotypes? |
| PubMedID- 22029024 | [40] truncal obesity is associated with metabolic syndrome and insulin resistance. |
| PubMedID- 23900353 | Hyperuricemia and its association with obesity and various components of metabolic syndrome have been documented in previous studies. |
| PubMedID- 24767168 | However, we could reach the statistical significance in the multiple linear regression models including visceral obesity (i.e., key component of the metabolic syndrome). |
| PubMedID- 25013207 | obesity is the hallmark of the metabolic syndrome that represents a cluster of different disorders which predispose people for the development of chronic metabolic diseases including t2dm and cardiovascular diseases [34]. |
| PubMedID- 25916862 | Renin-angiotensin-aldosterone system (raas) inhibition with an ace or an arb and treatment with calcium channel blockers appears safe and well tolerated in obesity-related hypertension and in patients with metabolic syndrome. |
| PubMedID- 26291691 | obesity is strongly associated with metabolic syndrome. |
| PubMedID- 25527815 | Background: obesity is the hallmark of the metabolic syndrome representing a major global health problem. |
| PubMedID- 25621503 | It is well known that an increase in adipokine production can influence glucose metabolism, insulin sensitivity and inflammation, and this finding could represent a molecular link between obesity and the development of diabetes mellitus, metabolic syndromes and cardiovascular diseases [77]. |
| PubMedID- 23247731 | Visceral (central) obesity is a hallmark of metabolic syndrome and is a risk factor for type 2 diabetes and cardiovascular disease.40, 41, 42 furthermore, goodpaster et al.43 showed in humans that abdominal subcutaneous adiposity can predict insulin sensitivity independently of visceral adiposity.43 ethanol consumption has been identified as a risk factor for the deposition of abdominal or visceral adipose tissue.44, 45, 46 ethanol has been shown to suppress lipid oxidation, which results in the preferential deposition of nonoxidized lipids in the abdominal region.47, 48 our study suggests that cpee alters lipid metabolism in offspring and causes increased adipocyte deposition in both the visceral and subcutaneous regions. |
| PubMedID- 25134788 | Objective: non-alcoholic fatty liver disease (nafld) is closely linked to obesity and constitutes part of the metabolic syndrome, which have been associated with low serum vitamin d (vd). |
| PubMedID- 22847239 | obesity is the hallmark of the metabolic syndrome and predisposes patients to the development of major chronic metabolic diseases including type 2 diabetes mellitus. |
| PubMedID- 24511516 | Diabetes, hyperlipidemia and obesity form the basis of the metabolic syndrome; it was shown to be an independent predictor of poor outcomes in heart transplant recipients. |
| PubMedID- 22768054 | Wistar ottawa karlsburg rt1u (wokw) rats are white in color (albino), powerfully built and develop facets of metabolic syndrome with obesity, dyslipidemia, insulin resistance, hyperinsulinemia, hyperleptinemia and glucose intolerance [5]–[10]. |
| PubMedID- 26255568 | Metabolic syndrome, abdominal obesity and hyperuricemia in schizophrenia: results from the face-sz cohort. |
| PubMedID- 25672777 | Metabolic syndrome (mets) is associated with abdominal obesity, hyperlipidemia, insulin resistance, and type 2 diabetes mellitus, and increases the risk of cardiovascular disease. |
| PubMedID- 22701716 | These data also suggest that modifying the availability or metabolism of saturated fatty acids may limit the inflammation associated with obesity leading to metabolic syndrome. |
| PubMedID- 22778575 | The patient had metabolic syndrome with obesity, a history of hypertension for 10 years, diabetes mellitus type ii. |