eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | squamous cell carcinoma of head and neck |
| Comorbidity | |squamous cell carcinoma |
| Sentences | 200 |
| PubMedID- 21211041 | An interesting anecdotal report showed a couple diagnosed synchronously with squamous cell carcinoma of the head and neck where the tumours were positive for hpv16 by pcr and both viral genomes were genetically identical and closely related to hpv16r - the revised european prototype. |
| PubMedID- 22174496 | Inclusion criteria were age between 18 to 75 years, histologically proven, locally advanced inoperable non-metastatic stage iv squamous cell carcinoma of head and neck. |
| PubMedID- 24742019 | In head and neck cancer cetuximab is approved in combination with radiotherapy as a curative treatment option for patients with locally advanced squamous cell carcinoma of the head and neck (lascchn). |
| PubMedID- 20459770 | [17] described that cetuximab was effective in combination with platinum-based regimens for recurrent or metastatic squamous cell carcinoma of the head and neck. |
| PubMedID- 22276044 | Taxotere® (sanofi-aventis, bridgewater, nj) is a potent chemotherapeutic agent approved for use in breast cancer, non-small-cell lung cancer, metastatic castrate-resistant prostate cancer, gastric adenocarcinoma and squamous cell carcinoma of the head and neck [1–3]. |
| PubMedID- 24259307 | Ccr7 also plays an important role in squamous cell carcinoma of the head and neck (scchn). |
| PubMedID- 20398256 | squamous cell carcinoma of the head and neck (scchn) represents the eighth leading cause of cancer worldwide. |
| PubMedID- 23966948 | For some tumors such as squamous cell carcinoma of the head and neck there is even a rationale for hyperfractionated radiotherapy with twice daily irradiation of 1.2–1.4 gy per fraction [reviewed in nguyen and ang (2002)]. |
| PubMedID- 24019973 | squamous cell carcinoma of the head and neck (scchn) constitutes an estimated 2.5% of cancer diagnoses in the united states, with 41,380 new cases diagnosed and an estimated 7,890 deaths in 2013 [2]. |
| PubMedID- 24083351 | New combinations, such as tpf regimene (docetaxel or paclitaxel, platinum, and 5-fu) have been shown to be superior to standard pf regimen (platinum, and 5-fu) for squamous cell carcinoma of the head and neck (hnscc) in numerous phase iii trials. |
| PubMedID- 24599269 | While radiation, chemotherapy, and surgery are routinely used to manage locally advanced cancers such as melanoma and squamous cell carcinoma of head and neck, the overall success of the treatment is often undermined by the incidence of metastasis at distant locations [1]. |
| PubMedID- 25743109 | High fadd expression was associated with regional and distant metastasis in squamous cell carcinoma of the head and neck [37].fasl and faskey death ligand and its receptor, respectivelyfas-sensitive melanoma clones were highly tumorigenic but were rarely metastatic in wild-type syngeneic mice. |
| PubMedID- 21234340 | In squamous cell carcinoma of the head and neck, the presence, activity, but also suppression of tumor-specific ctl have been demonstrated. |
| PubMedID- 25910231 | squamous cell carcinoma of the head and neck (scchn) and lung cancers are the two major tobacco-related cancers. |
| PubMedID- 24199193 | Stat3 decoy inhibited proliferation and stat3 mediated gene expression in squamous cell carcinoma of the head and neck in vitro as well as in a xenograft model in vivo [142, 143]. |
| PubMedID- 24885068 | A broad-based search strategy will be used to identify all published opscc and squamous cell carcinoma of the head and neck (scchn) rcts. |
| PubMedID- 21911989 | To be eligible to participate in the rcts, adult patients had histologically confirmed advanced (stage iii or iv) squamous cell carcinoma of the head and neck. |
| PubMedID- 24518612 | This mechanism has been described in multiple myeloma, where il-6 overexpression led to increased jak/stat3 activity [52], as well as in squamous cell carcinoma of the head and neck, where elevated levels of transforming growth factor-α (tgf-α) and subsequent stat3 activation abrogated apoptosis of epithelial cells [53]. |
| PubMedID- 25432639 | The better oxygenation the higher local control is observed in irradiated patients (particularly for squamous cell carcinoma of the head and neck and uterine cervix). |
| PubMedID- 21829508 | Among disease entities with more than 10 patients tested, no nras mutations were found in ovarian cancer, and squamous cell carcinoma of head and neck. |
| PubMedID- 24489833 | Hb, hospital based; pb, population based; fb, family based; nhl, non-hodgkin lymphoma; scchn, squamous cell carcinoma of the head and neck; hnc, head and neck cancer; pcr-rflp, polymerase chain reaction-restriction fragment length polymorphism; apex, arrayed primer extension; hrm, high resolution melting; maf, minor allele frequency; hwe, hardy-weinberg equilibrium. |
| PubMedID- PMC3442798 | squamous cell carcinoma of the head and neck (scchn) is the sixth most common cancer and carries a poor survival rate. |
| PubMedID- 22666080 | squamous cell carcinoma of the head and neck is the sixth most common cancer worldwide, with nearly 50,000 cases diagnosed annually [1]. |
| PubMedID- 20937120 | squamous cell carcinoma of the head and neck (scchn), radiation therapy commonly causes pronounced mucositis. |
| PubMedID- 25815200 | 2010 [20]omalizumabuncontrolled severe allergic asthmanovartis pharmaceuticals australia pty ltdpbsfinancially-based; outcome-basedpbs schedule [16], medicare australia [14]afliberceptage-related macular degenerationbayer australia ltdpbsfinancially-based; outcome-basedpbs schedule [16], medicare australia [14]ranibizumabage-related macular degenerationnovartis pharmaceuticals australia pty ltdpbsfinancially-based; outcome-basedpbs schedule [16], pbpa relativity sheets [17], public summary document [18], medicare australia [14]eltrombopagsevere chronic immune idiopathic thrombocytopenic purpuraglaxosmithkline australia pty ltdpbsfinancially-based; outcome-basedpbpa relativity sheets [17], medicare australia [14]romiplostimsevere chronic immune idiopathic thrombocytopenic purpuraamgen australia pty ltdpbsfinancially-based; outcome-basedpbs schedule [16], medicare australia [14]acs = acute coronary syndromes; all = acute lymphoblastic leukemia; aml = acute myeloid leukemia; cml = chronic myeloid leukemia; dvt = deep vein thrombosis; evar = endovascular aneurysm repair; gist = gastrointestinal stromal tumor; mbs = medicare benefits schedule; mcrc = metastatic colorectal cancer; mi = myocardial infarction; pah = pulmonary arterial hypertension; pbs = pharmaceutical benefits scheme; pph = primary pulmonary hypertension; ra = rheumatoid arthritis; rcc = renal cell carcinoma; rrms = relapsing-remitting multiple sclerosis; scchn = squamous cell carcinoma of the head and neck. |
| PubMedID- 24455542 | [15] in another clinical trial 101 patients with the squamous cell carcinoma of head and neck underwent either hyperfractionated radiotherapy, with 74.4-79.2 gy delivered in 6.2-7 weeks (1.2 gy per fraction twice a day), or accelerated fractionation with concomitant boost, which delivered 68.7-72 gy in 6 weeks (1.8 gy per fraction a day and 1.5 gy per fraction a day to a boost filed as a second daily treatment for the last 11-12 treatment days). |
| PubMedID- 21716956 | Furthermore, several studies have reported that mmp-2, 3, 7, 9, 11, and 13, mt1-mmp, and timp-1 contributes functionally to squamous cell carcinoma of the head and neck (2). |
| PubMedID- 21836819 | In adults, human papilloma virus (hpv) is thought to initiate cervical carcinoma and squamous cell carcinoma of the head and neck, at least in part by inactivating rb through expression of the e7 oncoprotein (fig. |
| PubMedID- 24429391 | Additionally, in squamous cell carcinoma of the head and neck (hnscc), persistent expression of klf4 correlated with poor prognosis, specifically in patients with advanced disease [85]. |
| PubMedID- 20470428 | In a phase iii trial, adding cetuximab, an egfr inhibitor, to rt provided improvement in locoregional control and overall survival on squamous cell carcinoma of the head and neck [27]. |
| PubMedID- 24769813 | squamous cell carcinoma of the head and neck (scchn) is the seventh leading cause of cancer death worldwide [1]. |
| PubMedID- 24574655 | squamous cell carcinoma of the head and neck (scchn) frequently metastasizes to the regional lymph nodes which are the first site of arrest of tumor cells that have invaded the peritumoral lymphatics, hence the strongest predictor of disease prognosis and outcome. |
| PubMedID- 20725831 | Dwi is reported to be superior to conventional methods in recognizing malignant neck nodes in adult patients with squamous cell carcinoma of the head and neck [18, 26, 27]. |
| PubMedID- 21426588 | To be included, all the patients had to have a biopsy-proven previously untreated iv (m0) unresectable squamous cell carcinoma of the head and neck region, have no synchronous primary tumors, and be ≥18 years old. |
| PubMedID- 20413642 | Egfr family members have been identified to play a critical role in development, progression, and resistance to chemo-rt in nsclc, colorectal cancer, pancreatic cancer, squamous cell carcinoma of the head and neck, brain cancer, and breast cancer. |
| PubMedID- 24709421 | To address this hypothesis, we generated xenograft hnscc tumors with university of michigan-squamous cell carcinoma 22b (um-scc-22b) cells and observed that cisplatin treatment increased (p = .0013) the fraction of cscs [i.e., aldehyde dehydrogenase activity high and cluster of differentiation 44 high (aldh(high)cd44(high))]. |
| PubMedID- 23106176 | It is well recognized that patients with squamous cell carcinoma of the head and neck (scchn) represent a group that during and after treatment suffers from nutritional impairments [1]. |
| PubMedID- 21532618 | squamous cell carcinoma of the head and neck (hnscc) is the sixth most common cancer in the world with more than 850,000 cases diagnosed worldwide(chin et al 2006). |
| PubMedID- 22132735 | Atp: adenosine triphosphate; ck5/6: cytokeratin 5/6; crc: colorectal cancer; dapi: 4': 6'-diamidino-2-phenylindole; egfr: epidermal growth factor receptor; er: estrogen receptor; fish: fluorescence in-situ hybridization; her2: human epidermal growth factor receptor-2; hnscc: squamous cell carcinoma of the head and neck; mbc: metastatic breast cancer; moabs: monoclonal antibodies; nsclc: non-small cell lung cancer; pi3k: phosphatidyl inositol 3'-kinase; pr: progesterone receptor; real time pcr: real-time quantitative polymerase chain reaction; ssc: saline sodium citrate buffer; tgf-α: transforming growth factor-alpha; tki: tyrosine kinase inhibitors. |
| PubMedID- 21269250 | Cilengitide added to cisplatin, 5-fluorouracil (5-fu), and cetuximab is also being evaluated in an open-label, randomized, controlled phase i/ii study (advantage) in subjects with recurrent and/or metastatic squamous cell carcinoma of the head and neck (scchn) [140, 143]. |
| PubMedID- PMC4070603 | Narrow band imaging for detecting superficial squamous cell carcinoma of the head and neck in patients with esophageal squamous cell carcinoma. |
| PubMedID- 24083572 | Furthermore, moderate anemia was also confirmed as an independent prognostic factor in squamous cell carcinoma of the head and neck treated with radiotherapy alone [9]. |
| PubMedID- 24141978 | Cetuximab was approved for treating egfr-expressing metastatic crc (mcrc) without activating kras mutation, and squamous cell carcinoma of the head and neck (scchn)4, but yet for gc. |
| PubMedID- 23901215 | Ldn increased the latency from visible to measurable tumors up to 1.6-folds and markedly reduced tumor volume and weight, and decreased dna synthesis in squamous cell carcinoma of the head and neck. |
| PubMedID- 20588277 | squamous cell carcinoma of the head and neck (scchn) is the sixth commonest cancer in the world, with an estimated global incidence of 500 000 cases per year (parkin et al, 2005). |
| PubMedID- 24558420 | Pcr: polymerase chain reaction; pcr-rflp: pcr-restriction fragment length polymorphism; taqman: taqmansnp; aml: acute myeloid leukemia; scchn: squamous cell carcinoma of the head and neck; hwe: hardy-weinberg equilibrium. |
| PubMedID- 20396597 | These cells display potent cytotoxicity against squamous cell carcinoma of the head and neck (scchn) cell lines among others, and are resistant to fasl-mediated apoptosis. |
| PubMedID- 22515371 | Salvage options are limited for recurrent, previously-irradiated squamous cell carcinoma of the head and neck (rscchn), resulting in an overall poor prognosis with a reported median survival of less than one year [1]. |
| PubMedID- 24497981 | Found that xrcc1 arg399gln was a protective factor for squamous cell carcinoma of the head and neck in young adults [52]. |
| PubMedID- 22737624 | In a collaborative study with dr. theresa whiteside, my laboratory identified aldh1a188–96 peptide as a shared ctl-defined human tumor antigen (ta) in squamous cell carcinoma of the head and neck (scchn).4 given that only one or two exchanges distinguish the peptides encoded by codons 88–96 of the aldh1/3 isoforms, particular attention was paid to ensure that the hla-a2-restricted ctl were specific for the aldh1a188–96 peptide. |