eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | c syndrome |
| Comorbidity | |obesity |
| Sentences | 307 |
| PubMedID- 24205128 | Nafld is a common feature of metabolic syndrome being often associated with obesity, dyslipidemia and diabetes and mostly closely linked to insulin resistance. |
| PubMedID- 24829483 | The discovery that mice harboring a mutation in the core circadian gene circadian locomotor output cycles kaput (clock) develop obesity and evidence of the metabolic syndrome represented a seminal moment for the field, clearly establishing a link between circadian rhythms, energy balance, and metabolism at the genetic level. |
| PubMedID- 23921778 | Conclusions: individuals with obesity and components of the metabolic syndrome reported significant improvements in most domains of the quality of life with a modest weight loss of 3.7% of initial weight, which was achieved within the first 6 months of treatment. |
| PubMedID- 24741661 | [2] metabolic syndrome is associated with overweight and obesity and on the other hand is a risk factor for cardiovascular disease and diabetes too. |
| PubMedID- 21884160 | This paper reviews epidemiological evidence demonstrating the association between chronic social stress and development of obesity and symptoms leading to metabolic syndrome. |
| PubMedID- 20549135 | Objective: in this study we compared the ability of this index to identify hypertension and metabolic syndrome with other obesity indexes (body mass index--bmi; waist circumference--wc; and waist-to-hip ratio - whr) by receiver operating characteristic (roc) curve analyses. |
| PubMedID- 19863955 | Background: in obese patients, positioning of the bioenterics intragastric balloon (bib) proved beneficial for weight loss, but the effect of the device on ameliorating some components of the metabolic syndrome associated with obesity remains uncertain. |
| PubMedID- 25774202 | The development of metabolic syndrome in obesity was often accompanied with impaired adipose tissue glucose and lipid metabolism. |
| PubMedID- 22673409 | Amh levels were not significantly related with obesity, indices of insulin resistance, and metabolic syndrome-related variables in both pcos and control groups. |
| PubMedID- 21083873 | Our patient's medical history included metabolic syndrome with second-degree obesity as indicated by a body mass index of 39 kg/m2, orally treated diabetes mellitus type 2b, stage ii arterial hypertension according to world health organization (who) criteria, compensated renal insufficiency following a left nephrectomy for a hypernephroid clear-cell carcinoma (p-t2n0m0g1) in 1985 and an uncertain penicillin allergy, although piperacillin was tolerated with no problems during the reported treatment. |
| PubMedID- 20418190 | After excluding patients with potential monogenic syndromes or diseases associated with obesity, we evaluated the association of the single nucleotide polymorphisms (snps) rs1861868 and rs9939609 of the fat-mass and obesity-associated fto gene with an inherited predisposition to morbid obesity. |
| PubMedID- 25591987 | Taken together, it is clear that baff unites obesity with metabolic syndrome. |
| PubMedID- 24567123 | This goal was initiated by noting that metabolic syndrome is associated with obesity, insulin resistance and an atherogenic dyslipidemia that includes reduced levels of circulating hdl. |
| PubMedID- 20129610 | The risk of obesity-induced metabolic syndrome is higher in asians than in caucasians. |
| PubMedID- 22809366 | In addition, fatty liver is a manifestation of metabolic syndrome, and is associated with obesity, type 2 diabetes mellitus (t2dm), and hypertriglyceridemia [11]. |
| PubMedID- 24815358 | Metabolic syndrome, including obesity, diabetes/insulin resistance, hypertension and dyslipidemia is a major threat for public health in the modern society. |
| PubMedID- 24663160 | Equine metabolic syndrome (ems) is associated with obesity and characterized by insulin resistance, decreased adiponectin, and elevated insulin, leptin, and pro-inflammatory cytokines. |
| PubMedID- 20092995 | Obtusiloba should be evaluated as a potential complementary treatment option for obesity associated with the metabolic syndrome. |
| PubMedID- 25715110 | Metabolic syndrome is closely associated with morbid obesity and leads to increased risk of cardiovascular diseases and related mortality. |
| PubMedID- 22392186 | In this study, we sought to assess the association between brachial artery fmd, high-sensitive c-reactive protein (hs-crp) and cardiovascular risk factors including obesity in patients with cardiac syndrome x. |
| PubMedID- 21147557 | Conclusions: the high prevalence of biochemical and physiological factors of metabolic syndrome, associated with overweight and obesity in mexico city adolescents, increases the risk of premature development of coronary atherosclerosis and diabetes mellitus in this population. |
| PubMedID- 20091093 | Overweight and obesity are associated with the metabolic syndrome (mets). |
| PubMedID- 23942780 | Hyperglycaemia, hypertension and obesity, major components of metabolic syndrome, are all associated with increased systemic and tissue levels of ang ii. |
| PubMedID- 22645521 | Levels of leptin and adiponectin would increase concomitant with increased fat mass, and metabolic syndrome associated with obesity and sedentary behavior would decrease activation of ampk in multiple cell types, thus blunting core clock and clock-controlled gene expression patterns throughout the reproductive axis. |
| PubMedID- 22546774 | Background: fatty liver disease (fld) is characterized by increased intrahepatic triglyceride content with or without inflammation and is associated with obesity, and features of the metabolic syndrome. |
| PubMedID- 25514913 | Specific co-morbidities correlated to the presence of obesity and associated with metabolic syndrome should always be ruled out in patients affected by nash-related end-stage liver disease, who are potential candidates for liver transplantation. |
| PubMedID- 26473366 | Both insulin resistance and central obesity predict the development of metabolic syndrome, which increases the risks of type 2 diabetes, hyperlipidemia, and cardiovascular disease [6–8]. |
| PubMedID- 22662254 | Transgenic over-expression of 11β-hsd1 in adipose tissue recapitulates the metabolic syndrome in mice, with visceral obesity, dyslipidemia, insulin resistance/diabetes and hypertension [2], [5]. |
| PubMedID- 21756079 | Objective: based on the role of polycystic ovary syndrome as a cause of metabolic syndrome with chronic anovulation, obesity, hyperinsulinemia and hyperandrogenism, development of effective treatment for its obesity is a priority. |
| PubMedID- 26063458 | Metabolic syndrome is linked with obesity and is often first identified clinically by elevated bmi and elevated levels of fasting blood glucose that are generally secondary to insulin resistance. |
| PubMedID- 20514047 | In this regard the ability of adipose tissue to expand and match the storage needs of energy surplus may be a key determinant of the susceptibility to developing metabolic syndrome associated with obesity (1-4). |
| PubMedID- 20835560 | Da-paz-filho et al.13 described a decrease in leptin production by adipose tissue in obesity associated with severe metabolic syndrome, suggesting a state of relative leptin deficiency in obesity that is associated with advanced stages of the syndrome. |
| PubMedID- 26439630 | Over the last decades, increased obesity is associated with increased metabolic syndromes characterized by type-2-diabetes (t2d), cardiovascular diseases (cvd) or low-grade inflammation. |
| PubMedID- 23435016 | In mice, a two to three-fold elevation of 11β-hsd1 selectively in adipose tissue phenocopies the metabolic syndrome, with central obesity, insulin resistance, dyslipidaemia and hypertension [115,116] whereas similar transgenic expression of 11β-hsd2 in adipocytes (it is not normally expressed in adipocytes), presumably lowering intra-adipose glucocorticoid action, causes insulin sensitisation in high fat fed mice [117]. |
| PubMedID- 21842287 | It is a well-known fact that severe obesity is associated with the metabolic syndrome, type 2 diabetes, cardiovascular disease, hypertension, and other diseases. |
| PubMedID- 22998948 | We have developed new dynamic tests to dissect the mechanisms regulating hpa axis central negative feedback sensitivity in humans, and demonstrated that this may be altered in obesity, one component of the metabolic syndrome. |
| PubMedID- 24269186 | In this study, we aim to examine the associations of obesity related loci with risk of metabolic syndrome (mets) in a children population from china. |
| PubMedID- 23161371 | We have previously reported that obesity with features of metabolic syndrome (obesity, insulin-resistance, dyslipidaemia) decreases myocardial resistance to i-r compared with lean insulin-sensitive animals. |
| PubMedID- 26096168 | Metabolic syndrome is characterized with abdominal obesity, insulin resistance, dyslipidemia and hepatic dysfunction. |
| PubMedID- 22043167 | However, sim1 heterozygotes were viable but developed early-onset hyperphagic obesity with clinical features of metabolic syndrome. |
| PubMedID- 25755863 | Methods: total of 94 patients were divided into obesity with metabolic syndrome (ms) (n=30), obesity without ms (n=33), and control (n=31) groups. |
| PubMedID- 21834955 | The relationship between depression and waist circumference or abdominal obesity as a component of metabolic syndrome has been explored previously in studies examining the associations of metabolic syndrome with mental illness [39-43]. |
| PubMedID- 20236509 | This finding is consistent with the observation that in children, obesity is strongly associated with metabolic syndrome [10,11]. |
| PubMedID- 21747976 | Angiotensinogen has also been suggested as a link between obesity and the development of the metabolic syndrome [67]. |
| PubMedID- 20436743 | Diabetes, hypertension, metabolic syndrome, smoking, obesity, etc) remain similar to those described elsewhere in the world. |
| PubMedID- 24467470 | The key search terms were bipolar disorder and metabolic syndrome cross-referenced with gender, sex, obesity, diabetes mellitus, hypertension, and dyslipidemia. |
| PubMedID- 20224753 | It is also recognized that many subjects with osa have central obesity and other features of metabolic syndrome [39], which is most widely accepted as being comprised of hyperinsulinemia, glucose intolerance, dyslipidemia, central obesity, and hypertension [58]. |
| PubMedID- 26298466 | Thbs1 may act as a critical circulating factor that couples obesity with metabolic syndrome and diabetes in humans. |
| PubMedID- 25713801 | Non-alcoholic fatty liver disease (nafld) represents the most common liver disorder in western countries and it is commonly associated with obesity and progression of the metabolic syndrome. |
| PubMedID- 24031137 | Association of gene polymorphism of the fat mass and obesity associated gene with metabolic syndrome: a retrospective cohort study in japanese workers. |