eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | squamous cell carcinoma of head and neck |
| Comorbidity | |squamous cell carcinoma |
| Sentences | 200 |
| PubMedID- 21811352 | [2] we are focusing on the squamous cell carcinoma of head and neck region (scchn) as they are the most common in the head and neck region. |
| PubMedID- 24567516 | Recurrent and/or metastatic squamous cell carcinoma of the head and neck (r/m-scchn) overexpresses αvβ5 integrin. |
| PubMedID- 25619559 | Most patients with squamous cell carcinoma of the head and neck (hnscc) present with locally advanced disease (stage iii–iv), and 5-year overall survival (os) rates with multimodality treatment are 40–60% 1. induction chemotherapy (ic) may be employed as a treatment strategy for locally advanced hnscc, as it has the advantages of potential organ preservation, early identification of patients likely to benefit from chemoradiotherapy (crt), and decreased incidence of distant metastases. |
| PubMedID- 22699626 | The relationship between hpv, improved prognosis and good response to therapy for squamous cell carcinoma of the head and neck may also be true for a subset of lnec. |
| PubMedID- 22384298 | Consistent with most previous reports [2], the predominant primary lesion was a squamous cell carcinoma of the head and neck region. |
| PubMedID- 21750773 | Only subjects with stage iii-ivb squamous cell carcinoma of the head and neck (scchn) were included. |
| PubMedID- 20565817 | Further non-gastrointestinal indications for cetuximab include scchn (squamous cell carcinoma of the head and neck), and nsclc (non-small cell lung cancer). |
| PubMedID- 24376779 | Tumor blocks for sixty-four patients diagnosed with mucosal derived squamous cell carcinomas of head and neck (hnscc) from 1989 and 2007 at the city of hope national medical center (duarte, ca) were retrospectively analyzed. |
| PubMedID- 25788275 | squamous cell carcinoma of the head and neck represents 4% of all cancers diagnosed worldwide, with >500.000 new cases recorded in 2008. of them, 151.000 cases (130.000 men and 21.000 women) were laryngeal cancer with an estimated age-standardized world mortality rate of 2.3/100.000 habitants. |
| PubMedID- 24124726 | These results indicate that e1b55kd-deficient ad, including dl1520 and oncorine (h101)[46,47], an oncolytic ad approved by the state food and drug administration for the clinical application to treat squamous cell carcinoma of the head and neck, may be useful for the treatment of gastric cancer. |
| PubMedID- 25946011 | [4] found that patients diagnosed with advanced squamous cell carcinoma of the head and neck (scchn) had shorter survival time and higher medical cost than those with less advanced scchn. |
| PubMedID- 25885109 | Inclusion criteria for this prospective single centre pilot study were as follows: age ≥18 years old, histologically proven squamous cell carcinoma of the head and neck region, who performance status 0-2, decision to proceed with (chemo)radiotherapy with curative intent following discussion in a multi-disciplinary meeting, measurable primary cancer on routine pre-treatment imaging (ct and/or mri), and provision of fully informed consent. |
| PubMedID- 22578076 | We identified 52 patients with invasive squamous cell carcinoma of the head and neck treated at the university of arizona radiation oncology departmentfrom 2007 to 2010. median age at diagnosis was 63 years-old (range: 25–92 years old). |
| PubMedID- 22428009 | Krt19 is also known as an epigenetically regulated tumor suppressor gene, which has frequently demonstrated promoter hypermethylation associated with transcriptional downregulation in several cancerous tumors such as neuroblastomas, squamous cell carcinoma of the head and neck region and renal cell carcinomas [36]–[38]. |
| PubMedID- 24410919 | All patients had histologically verified squamous cell carcinoma of the head and neck region, with tumours located mainly in the oral cavity (36 cases, 0.51; see table 1 for details on tumour locations) or the oropharynx (27 cases, 0.38). |
| PubMedID- 21595914 | Pleural effusion specimens from patients with non-small cell lung cancer (nsclc, n = 2) and squamous cell carcinoma of the head and neck region (scchn, n = 1), and ascitic fluid from patients with gastric (n = 2), colon cancer (n = 1) and ovarian cancer (n = 1) were collected. |
| PubMedID- 22449259 | Scchn: squamous cell carcinoma of the head and neck; spm: second primary malignancies; hr: hazard ratio; ci: confidence interval; hpv: human papillomavirus; cdks: cyclin-dependent kinases; snps: single nucleotide polymorphisms. |
| PubMedID- 20459769 | Randomized trials using lapatinib were recently initiated in patients with locally advanced squamous cell carcinoma of head and neck [10] and nsclc [4]. |
| PubMedID- 21864397 | In contrast to other squamous cell carcinoma of the head and neck, npc is characterized by a high tendency for metastatic dissemination [4,5]. |
| PubMedID- 20576147 | Primitive tumor corresponds mainly to squamous cell carcinoma of the head and neck or cervix, rarely to colon (2,3). |
| PubMedID- 22825751 | squamous cell carcinoma of the head and neck (scchn) is the 6th most common cancer type worldwide (1). |
| PubMedID- 20158573 | squamous cell carcinoma of the head and neck (scchn) is characterized by high expression of egfr in more than 90% of tumours relative to normal control tissue, and elevated expression correlates with poor disease control and metastasis [100, 101]. |
| PubMedID- 24213322 | Similar results have been reported regarding gefitinib sensitivity in cell lines from nsclc and squamous cell carcinoma of the head and neck (scchn) [1,5,7,10]. |
| PubMedID- 24774218 | It is reported that hpv infection may alter mirna profiles in squamous cell carcinoma of the head and neck cell lines [2]. |
| PubMedID- 21473769 | Likewise, squamous cell carcinoma of the head and neck exhibit a profile that is marked by decreased taurine, alanine, asparagine, aspartic acid, glycine, histidine, ornithine, phenylalanine, serine, and threonine, with a marked increase in levels of cystine. |
| PubMedID- 24619073 | Protection from lethal toxicity by msc was associated with enhanced antitumour activity in rats bearing advanced ward colorectal carcinoma and in nude mice bearing human squamous cell carcinoma of the head and neck, fadu, and a253 xenografts. |
| PubMedID- 24026482 | squamous cell carcinoma of the head and neck (hnscc) is a disease of considerable morbidity and mortality with an estimated 560,000 cases per year and 300,000 deaths worldwide, and approximately 50,000 new cases and 11,000 deaths in the united states annually12. |
| PubMedID- 25670907 | A multidisciplinary strategy incorporating surgery, radiotherapy (rt), and chemotherapy improves the treatment outcome in locally advanced squamous cell carcinoma of the head and neck (la-scchn). |
| PubMedID- 22745915 | Worldwide, squamous cell carcinoma of the head and neck (scchn) is the sixth most common cancer and is diagnosed in more than 600,000 patients each year [1]. |
| PubMedID- 21547152 | In squamous cell carcinoma of the head and neck (scchn) we demonstrated good tumor/background ratios with [18f]galacto-rgd pet, with again a widely varying intensity of tracer uptake. |
| PubMedID- 22970424 | Gist, gastrointestinal stromal tumor; nsclc, non-small cell lung cancer; scchn, squamous cell carcinoma of the head and neck; sclc, small cell lung cancer; tcc, transitional cell carcinoma of the urothelium. |
| PubMedID- 26060497 | Recurrent squamous cell carcinoma of head and neck (scchn) is incurable with palliative chemotherapy resulting in a median survival of 8–10 months. |
| PubMedID- 24278149 | However, in stratified analysis, we found that either the rs2910164 c allele or the cc genotype was protective against bladder cancer, prostate cancer, cervical cancer, and colorectal cancer, whereas it was a risk factor for papillary thyroid carcinoma and squamous cell carcinoma of the head and neck (scchn). |
| PubMedID- 20691082 | Weber, a et al had reported that hsp70 was significantly upregulated in squamous cell carcinoma of the head and neck (scchn) [7]. |
| PubMedID- 24334439 | 18f-labeled galacto-rgd is the first tracer investigated in patients with squamous cell carcinoma of the head and neck and metastases of malignant melanoma, sarcomas, or osseous metastases, but not in patients with gliomas[16,17]. |
| PubMedID- 22369429 | In our study 148 patients with squamous cell carcinoma of the head and neck were included prospectively, all diagnosed at the department of otolaryngology of the medical university of vienna. |
| PubMedID- 22091433 | Cigarette smoking and alcohol consumption are well-established risk factors for developing squamous cell carcinoma of the head and neck. |
| PubMedID- 24339539 | Onyx-015 has been tested in phase 1 and 2 trials on squamous cell carcinoma of head and neck that resulted in tumor regression, which correlate to the p53 status of the tumor. |
| PubMedID- 24900970 | Paclitaxel and docetaxel have been used as chemotherapy agents to treat squamous cell carcinoma of the head and neck in selected patients with survival benefits in clinical practice [11–13]. |
| PubMedID- 21773035 | Unlike squamous cell carcinoma of the head and neck or esophagus, egfr had no influence on prognosis. |
| PubMedID- 22084724 | Taking also into consideration that squamous cell carcinoma of head and neck is usually a heterogeneous tumor, it is hard to expect that a 12-mer peptide effectively and sequence-specifically targets all hnscc tumors. |
| PubMedID- 25675045 | Compared with normal tissues, iqgap1 overexpression is found in colorectal carcinoma,13 breast cancer,14 astrocytoma,15 and squamous cell carcinoma of the head and neck.16 for instance, clark et al17 identified by a screen of genes that iqgap1 and its binding proteins calmodulin and erk showed a greater than 2.5-fold increase in metastatic cells in a mouse model with metastatic melanoma. |
| PubMedID- 20529374 | Despite such aggressive approaches, advanced squamous cell carcinoma of the head and neck tends to recur locoregionally and, thus, presents a significant clinical challenge [1-3]. |
| PubMedID- 26052534 | Clg was for recurrent or refractory squamous cell carcinoma of the head and neck (scchn), and advexin was for li-fraumeni cancer. |
| PubMedID- 22720145 | Fanconi anemia (fa) is a recessive chromosomal instability syndrome with diverse clinical symptoms and a high risk for acute myeloid leukemia and squamous cell carcinoma of the head and neck region [1]. |
| PubMedID- 22655205 | Patients with squamous cell carcinoma of head and neck (scchn) who had disease recurrence after primary surgery or chemoradiation therapy or who present with metastatic disease usually have a poor prognosis [1]. |
| PubMedID- 21689432 | squamous cell carcinoma of the head and neck (scchn) is the fifth most common cancer worldwide [1], which includes malignancies at the sites of the oral cavity, larynx and pharynx. |
| PubMedID- 25949173 | It has been well known that plk1 expression increased in various cancer tissues such as non small cell lung cancer (wolf et al., 1997), squamous cell carcinoma of the head and neck (knecht et al., 1999), esophageal cancer, gastric cancer (tokumitsu et al., 1999) and colorectal cancer (macmillan et al., 2001). |
| PubMedID- 24602188 | In studies conducted in patients with squamous cell carcinoma of the head and neck, we have shown significantly reduced disease-free survival with the presence of increased “putative” ctcs [11]. |
| PubMedID- 22932448 | This suggests that cdk4 novel germline mutations observed in study may play a different and important role in squamous cell carcinoma of head and neck cancer in pakistani population. |