eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | severe combined immunodeficiency |
| Comorbidity | |severe combined immunodefic |
| Sentences | 113 |
| PubMedID- 22282699 | When severe combined immunodeficient mice injected with ba/f3 cells expressing bcr-abl isoforms and the firefly luciferase gene, a decrease in tumor burden measured by bioluminescence imaging was observed in das-treated mice harboring the wild-type bcr-abl and m351t, but not the t315i mutant.13 these experiments laid the ground for a first in human clinical trial. |
| PubMedID- 19834493 | Adult male severe combined immunodeficient (scid) mice [c.b.17/icrhsd-scid] were purchased (harlan, indianapolis, in). |
| PubMedID- 22941246 | Adult nonobese diabetic/severe combined immunodeficiency interleukin 2 receptor gamma chain knock out (nsg) mice (jackson laboratories, bar harbor, me), were used for in vivo experiments according to protocols approved by the institutional animal care and use committee of university of california los angeles. |
| PubMedID- 20594324 | 5-6 weeks old female severe combined immunodeficiency mice (scid) mice were obtained from harlan laboratory (harlan laboratories, inc, indianapolis, in) and maintained under pathogen free conditions in a temperature and humidity controlled animal care facility with a 12 hours light dark cycle. |
| PubMedID- 22829152 | The leukemic non-obese diabetic/severe combined immunodeficiency (nod/scid) mouse system with the in vivo combination treatment with imatinib and everolimus showed a decrease of tumor burden including cd34+ cells. |
| PubMedID- 21547019 | When severe combined immunodeficient (scid) mice that lack b- and t-lymphocytes are challenged with p. gingivalis, there is considerably less bone resorption than in wild-type normal mice (114). |
| PubMedID- 24595136 | Four-week-old female non-obese diabetic-severe combined immunodeficient (nod-scid) mice were purchased from the institute of zoology, chinese academy of sciences, and subcutaneously inoculated in the flank region with a suspension of h1975 cells (5.0×106 cells). |
| PubMedID- 25346775 | Adoptive immunization of severe combined immunodeficiency mice with t cells from 2d2 live-attenuated bpm mutant-immunized mice resulted in increased survival compared to naïve t cell recipients. |
| PubMedID- 24224014 | 6- to 8- week-old female cb-17 severe combined immunodeficient (scid) mice were obtained from the national cancer institute frederick animal production program and maintained in a pathogen-free facility prior to experiments according to guidelines of the animal research advisory committee of national institutes of health. |
| PubMedID- 20138044 | Akr, balb/c (harlan, uk), and severe combined immunodeficient (scid) mice were maintained in the biological services unit at manchester university. |
| PubMedID- 23152004 | Eight-week-old female immunodeficient nude and cb-17 severe combined immunodeficient (scid) mice (charles river laboratories, wilmington, ma, usa) were maintained in a pathogen-free environment, and all in vivo procedures were approved by the synta pharmaceuticals corp. institutional animal care and use committee in accordance with the guide for care and use of laboratory animals. |
| PubMedID- 24573252 | (1991) who showed that severe combined immunodeficient mice, deficient in dsb repair, were hypersensitive to direct dsb inducing ionising radiation or bleomycin treatment but normally sensitive to mitomycin c and uv light, which cause dna inter- and intra-strand crosslinks [29]. |
| PubMedID- 25798061 | Four- to six-week-old female balb/c severe combined immunodeficient (scid) were obtained from frederick cancer research and development center (national cancer institute) and housed in a specific pathogen-free animal facility. |