eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | monoclonal gammopathy of uncertain significance |
| Comorbidity | |monoclonal gammopathy |
| Sentences | 127 |
| PubMedID- 20602755 | In patients with monoclonal gammopathy of undetermined significance, the risk of progression to multiple myeloma at 25 year follow-up is around 30% [24]. |
| PubMedID- 22335280 | While a monoclonal gammopathy of unknown significance (mgus) may develop to systemic amyloidosis or myeloma (23) this does not seem to happen with a localized plasma cell clone associated with localized amyloidosis, which almost never progresses to a systemic disease (20,24,25). |
| PubMedID- 24813251 | Moreover, in various datasets there was a consistent, significant reduction in yap1 expression levels, progressing from normal plasma cells to monoclonal gammopathy of undetermined significance (mgus) to mm (fig. |
| PubMedID- 21533133 | monoclonal gammopathy of undetermined significance (mgus) is a paraproteinemic disorder and a possible cause for slowly progressive symmetric distal sensorimotor neuropathy. |
| PubMedID- 24808988 | Scls is often accompanied by a monoclonal gammopathy of unknown significance (mgus). |
| PubMedID- 24198839 | Other associated conditions included hiv infection [9, 11, 16, 20], ethanol abuse [1, 5], gastric carcinoma [14, 19], barrett esophagus [22], monoclonal gammopathy of uncertain significance [8], and concurrent hepatitis c infection and insulin-dependent diabetes mellitus [17]. |
| PubMedID- 25644365 | Background: recently, new guidelines for the monitoring and the risk evaluation of monoclonal gammopathy with undetermined significance (mgus) became available and the light chain mgus subtype was defined. |
| PubMedID- 24098716 | Exclusion criteria included the following: any previously known neuromuscular disease or condition at risk for peripheral neuropathy, such as diabetes, systemic diseases with renal, hepatic or thyroid dysfunction, alcohol abuse, hiv or hepatitis c infection, hematological diseases or monoclonal gammopathy of uncertain significance, vitamin b12 deficiency, connective tissue diseases (e.g. |
| PubMedID- 24466560 | In fact, an igm monoclonal component can be found in other lymphoproliferative disorders, such as chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll), splenic marginal zone lymphoma (smzl), diffuse large cell lymphoma (dlcl), mantle cell lymphoma (mcl), myeloma and igm monoclonal gammopathy of undetermined significance (igm-mgus)(table 1). |
| PubMedID- 22189730 | Patients diagnosed with monoclonal gammopathy of undetermined significance or poems (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome were excluded from this study. |
| PubMedID- 21430775 | However, these abnormalities are likely insufficient for malignant transformation because they are also observed in the pre-malignant syndrome known as monoclonal gammopathy of uncertain significance (mgus). |
| PubMedID- 25605012 | We performed expression analysis to determine whether hspa5 expression was upregulated in patients with the pre-malignant condition monoclonal gammopathy of unknown significance (mgus) that nearly uniformly precedes mm. |
| PubMedID- 22812447 | Finally, the diagnosis was widespread cryoglobulinemic vasculitis with skin, lung, and kidney involvement secondary to monoclonal gammopathy of undetermined significance associated with sjögren’s syndrome. |
| PubMedID- 24032087 | Rare cases may develop in association with a paraproteinemia such as monoclonal gammopathy of unknown significance (mgus). |
| PubMedID- 25789189 | A 70-year-old caucasian male with monoclonal gammopathy of undetermined significance (mgus) and high risk adenocarcinoma of the prostate (t3b, gleason score: 3 + 4 = 7, prebiopsy psa: 74.3 ng/ml) who completed external beam radiation therapy to the prostate, periprostatic lymphatics, seminal vesicles, and regional pelvic lymphatics concurrent with adt (leuprolide 22.5 mg im every 3 months) was found to have evidence of sclerotic and blastic bony lesions, suspicious for metastatic prostatic cancer, 6 months following primary therapy with restaging imaging (figure 3). |
| PubMedID- 22084694 | At this point, it was thought that the gammopathy was probably monoclonal gammopathy of undetermined significance. |
| PubMedID- 22826794 | Lane 2: negative control (patient with monoclonal gammopathy of undetermined significance). |
| PubMedID- 25887188 | Patients presenting with previously untreated mm (n = 332) or monoclonal gammopathy of unknown significance (mgus; n = 22) at the university hospitals of heidelberg and montpellier (hm group) as well as 10 healthy normal donors have been included in the study approved by the heidelberg ethics committee (#229/2003 and s-152/2010) after written informed consent was obtained in accordance with the declaration of helsinki. |
| PubMedID- PMC4044641 | Some patients may show a slow progressive evolution from monoclonal gammopathy of undetermined significance while others may be associated with features of high clonal aggressiveness such as plasma cell leukemia or extramedullary plasmacytomas. |
| PubMedID- 25685157 | Further features were hypogammaglobulinemia and monoclonal gammopathy of unclear significance (mgus). |
| PubMedID- 21785257 | monoclonal gammopathy of undetermined significance is the most common plasma cell dyscrasia, accounting for more than 60% of these diseases. |
| PubMedID- 24317090 | Patients 1 and 2 suffered from concomitant neutropenia, whereas patient 2 also had anemia and monoclonal gammopathy of unknown significance that had not required treatment thus far. |
| PubMedID- 26558251 | monoclonal gammopathy with undetermined significance (mgus) carries a risk of progression to multiple myeloma, and progression is usually diagnosed with changes in m-protein or bone marrow biopsy. |
| PubMedID- 22919534 | The lupus anticoagulant is a polyclonal immunoglobulin type igg; it has been reported in autoimmune disease, monoclonal gammopathy of unknown significance, and aids. |
| PubMedID- 24363850 | Any patient presenting with cardiomyopathy with preserved systolic function, heavy albuminuria, an unexplained sensorimotor peripheral neuropathy, hepatomegaly, or atypical monoclonal gammopathy of undetermined significance or myeloma should be suspected of having al amyloidosis [5]. |
| PubMedID- 21734887 | Plasma cell dyscrasia may manifest as plasmacytoma, multiple myeloma (mm), primary amyloidosis, or monoclonal gammopathy of unknown significance [1]. |
| PubMedID- 22848499 | Mgus: monoclonal gammopathy of undetermined significance. |