eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | metabolic syndrome x |
| Comorbidity | |obesity |
| Sentences | 300 |
| PubMedID- 24554764 | Kdm3a knockdown leads to immotile round-headed spermatozoa (globozoospermia) and metabolic syndrome associated with obesity and diabetes (okada et al., 2007; inagaki et al., 2009; tateishi et al., 2009; liu et al., 2010) through the regulation of genes involved in histone replacement during spermatogenesis and regulation of gene expression during adipogenesis. |
| PubMedID- 25648511 | High-carbohydrate, high-fat diet-fed rats showed the signs of metabolic syndrome leading to abdominal obesity, cardiovascular remodelling and non-alcoholic fatty liver disease. |
| PubMedID- 24467470 | The key search terms were bipolar disorder and metabolic syndrome cross-referenced with gender, sex, obesity, diabetes mellitus, hypertension, and dyslipidemia. |
| PubMedID- 22967456 | In addition, it has been reported that prenatally undernourished rats nursed by control mothers exhibit a rapid catch-up growth and are more susceptible to developing obesity and features of metabolic syndrome [58]. |
| PubMedID- 24489111 | High-fat diet is considered to be one of the main stressors that can induce negative effects in animals such as metabolic syndrome with obesity, insulin resistance, and fatty liver. |
| PubMedID- 24205128 | Nafld is a common feature of metabolic syndrome being often associated with obesity, dyslipidemia and diabetes and mostly closely linked to insulin resistance. |
| PubMedID- 24204674 | obesity is strongly associated with metabolic syndrome, hypertension, dyslipidemia and hyperglycemic tendencies that are represented at the molecular level by insulin resistance (ir) [1]. |
| PubMedID- 26090468 | Nafld is the hepatic expression of metabolic syndrome, being frequently associated with obesity, insulin resistance, and dyslipidemia [2]. |
| PubMedID- 22396222 | Taken together, these findings indicate that inhibiting adipogenic differentiation of hamscs by artemisinic acid occurs primarily through reduced expression of c/ebp delta, which is mediated by the inhibition of jnk and suggest that aremisinic acid may be used as a complementary treatment option for obesity associated with metabolic syndrome. |
| PubMedID- 24567123 | This goal was initiated by noting that metabolic syndrome is associated with obesity, insulin resistance and an atherogenic dyslipidemia that includes reduced levels of circulating hdl. |
| PubMedID- 20549135 | Objective: in this study we compared the ability of this index to identify hypertension and metabolic syndrome with other obesity indexes (body mass index--bmi; waist circumference--wc; and waist-to-hip ratio - whr) by receiver operating characteristic (roc) curve analyses. |
| PubMedID- 25516385 | Studies in adult populations show that retinal microvascular changes are associated with obesity and components of the metabolic syndrome. |
| PubMedID- 25715110 | metabolic syndrome is closely associated with morbid obesity and leads to increased risk of cardiovascular diseases and related mortality. |
| PubMedID- 22701354 | However, obesity is associated with metabolic syndrome characterized by alterations in glucose metabolism, lipids, and presence of hypertension [21]. |
| PubMedID- 22584415 | Some [39, 40], but not other [41, 42], authors found that plasma resistin levels positively correlate with obesity and other constituents of the metabolic syndrome. |
| PubMedID- 24321125 | obesity is strongly associated with metabolic syndrome, which is characterized by the presence of insulin resistance, hypertension, and hyperlipidemia. |
| PubMedID- 23247731 | Visceral (central) obesity is a hallmark of metabolic syndrome and is a risk factor for type 2 diabetes and cardiovascular disease.40, 41, 42 furthermore, goodpaster et al.43 showed in humans that abdominal subcutaneous adiposity can predict insulin sensitivity independently of visceral adiposity.43 ethanol consumption has been identified as a risk factor for the deposition of abdominal or visceral adipose tissue.44, 45, 46 ethanol has been shown to suppress lipid oxidation, which results in the preferential deposition of nonoxidized lipids in the abdominal region.47, 48 our study suggests that cpee alters lipid metabolism in offspring and causes increased adipocyte deposition in both the visceral and subcutaneous regions. |
| PubMedID- 22691465 | Which reported that metabolic syndrome with obesity occurs in 38.7% of moderately obese and 49.7% of severely obese children and adolescents. |
| PubMedID- 22777542 | According to skilton et al.,35 adjusting for bmi, in this case, will produce findings that address the association between macronutrient composition and the non-obesity components of the metabolic syndrome. |
| PubMedID- 25610182 | Objective: metabolic syndrome (ms) presents with central obesity, impaired glucose metabolism, dyslipidemia and hypertension. |
| PubMedID- 25683064 | Central obesity as a component of metabolic syndrome likely correlates with socioeconomic factors. |
| PubMedID- 20091093 | Overweight and obesity are associated with the metabolic syndrome (mets). |
| PubMedID- 24741661 | [2] metabolic syndrome is associated with overweight and obesity and on the other hand is a risk factor for cardiovascular disease and diabetes too. |
| PubMedID- 22537054 | The numbers of positive components in metabolic syndrome between subjects with central obesity and without central obesity. |
| PubMedID- 22645521 | Levels of leptin and adiponectin would increase concomitant with increased fat mass, and metabolic syndrome associated with obesity and sedentary behavior would decrease activation of ampk in multiple cell types, thus blunting core clock and clock-controlled gene expression patterns throughout the reproductive axis. |
| PubMedID- 26439630 | Over the last decades, increased obesity is associated with increased metabolic syndromes characterized by type-2-diabetes (t2d), cardiovascular diseases (cvd) or low-grade inflammation. |
| PubMedID- 24224148 | Pufas are used for metabolic syndrome related with obesity or diabetes. |
| PubMedID- 23435016 | In mice, a two to three-fold elevation of 11β-hsd1 selectively in adipose tissue phenocopies the metabolic syndrome, with central obesity, insulin resistance, dyslipidaemia and hypertension [115,116] whereas similar transgenic expression of 11β-hsd2 in adipocytes (it is not normally expressed in adipocytes), presumably lowering intra-adipose glucocorticoid action, causes insulin sensitisation in high fat fed mice [117]. |
| PubMedID- 22375551 | Nonalcoholic fatty liver disease (nafld) is regarded as a hepatic manifestation of the metabolic syndrome which is associated with obesity, insulin resistance, dyslipidemia and hypertension [1]. |
| PubMedID- 22998948 | We have developed new dynamic tests to dissect the mechanisms regulating hpa axis central negative feedback sensitivity in humans, and demonstrated that this may be altered in obesity, one component of the metabolic syndrome. |
| PubMedID- 24396679 | The crucial components that may link abdominal obesity to other features of the metabolic syndrome and end-organ damage are presumably the presence of insulin resistance and elevated insulin levels, increased inflammation with macrophage infiltration in fat tissues with concomitant release of proinflammatory cytokines, and endothelial dysfunction, which all may lead to sht. |
| PubMedID- 26323878 | Nafld is the most common chronic liver disease in children and adults, with its prevalence closely associated with obesity and other features of the metabolic syndrome. |
| PubMedID- 24716901 | Childhood obesity is also associated with metabolic syndrome including hyperinsulinemia/insulin resistance, dyslipidemia, and hypertension. |
| PubMedID- 21747976 | Angiotensinogen has also been suggested as a link between obesity and the development of the metabolic syndrome [67]. |
| PubMedID- 20516702 | These results indicate the urgent need to reduce abdominal obesity, an important indicator of the metabolic syndrome, in kuwaiti adolescents. |
| PubMedID- 24809933 | Accumulating evidence indicates that visceral fat obesity is located upstream of the metabolic syndrome and atherosclerosis910. |
| PubMedID- 22694047 | The prevalence of the metabolic syndrome with attendant morbid obesity continues to increase nationwide. |
| PubMedID- 24598991 | The results for women were consistent with previous studies that found that lower openness to experience is likely to be associated with obesity and the presence of metabolic syndrome [6], [10], [37]. |
| PubMedID- 24334510 | One important finding is that childhood obesity is highly associated with adult metabolic syndrome, type 2 diabetes, and cardiovascular diseases. |
| PubMedID- 20619835 | Background: the metabolic syndrome (mets) is associated with central obesity and leads to increased morbidity and mortality due to cardiovascular disease (cvd). |
| PubMedID- 23949560 | This attenuation may arise from causal biological correlations between insulin sensitivity, obesity, and clinical definitions of metabolic syndrome. |
| PubMedID- 26464753 | The pathogenesis of nafld associated non-cirrhotic hcc is distinct from that of cirrhotic hcc because the metabolic syndrome (ms) along with obesity and insulin resistance (ir) underlie several unique mechanisms that promote tumorigenesis. |
| PubMedID- 21277789 | Women of reproductive age are not spared from the complications of metabolic syndrome, which overlaps with obesity and polycystic ovary syndrome (pcos), both of which are linked to infertility and poor reproductive outcome. |
| PubMedID- 25713801 | Non-alcoholic fatty liver disease (nafld) represents the most common liver disorder in western countries and it is commonly associated with obesity and progression of the metabolic syndrome. |
| PubMedID- 25774202 | The development of metabolic syndrome in obesity was often accompanied with impaired adipose tissue glucose and lipid metabolism. |
| PubMedID- 24575123 | Variability at the adiponectin locus associated with obesity and other features of the insulin resistance syndrome has been studies intensively in the last years (comuzzie et al., 2001; menzaghi et al., 2007), but a limited number of studies have examined the role of heredity in the regulation of adiponectin among individuals of african heritage (miljkovic-gacic et al., 2007). |
| PubMedID- 20023693 | obesity is frequently associated with metabolic syndrome, a disease state that includes glucose intolerance, insulin resistance, hypertension, hypertriglyceridemia, low level of high-density lipoprotein cholesterol (hdl-c), and type 2 diabetes mellitus (t2dm)1. |
| PubMedID- 22691241 | Logistic regression (backward selection) was further performed to calculate odds ratios (ors) for high versus low homa-ir according to demographic and lifestyle (gender, age, tobacco use), metabolic (obesity, hypertension, use of statins, metabolic syndrome), and clinical parameters, including the das28, health assessment questionnaire (haq), crp, and ra treatment modality (glucocorticoids, methotrexate). |
| PubMedID- 22125617 | It is strongly associated to components of the metabolic syndrome including obesity, insulin resistance, dyslipidemia and type 2 diabetes mellitus (t2dm) [2], and it is estimated that up to one third of the general population in western societies may have hepatic steatosis [3]. |
| PubMedID- 23942780 | Hyperglycaemia, hypertension and obesity, major components of metabolic syndrome, are all associated with increased systemic and tissue levels of ang ii. |