eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | c syndrome |
| Comorbidity | |obesity |
| Sentences | 307 |
| PubMedID- 21276250 | This would be relevant to many developing countries with poor resources, such as those in south asia, which are battling rapid increases in diabetes, obesity and other components of the metabolic syndrome. |
| PubMedID- 23208524 | Nafld may represent the hepatic manifestation of the metabolic syndrome with visceral obesity, dyslipidaemia, and insulin resistance [198]. |
| PubMedID- PMC4150581 | (central) obesity is a hallmark of the metabolic syndrome of which the other components are: dyslipidaemia, hypertension, impaired glucose metabolism, with insulin resistance and diabetes type 2. particularly if poorly controlled, there is a significant association between low level of total testosterone or dhea-s and indices of poorly controlled type 2 diabetes. |
| PubMedID- 21754922 | Ffas cause insulin resistance in all major insulin target organs (skeletal muscle, liver, and endothelial cells) and have emerged as a major link between obesity, the development of the metabolic syndrome, and atherosclerotic vascular disease [11]. |
| PubMedID- 23201770 | These results suggest that tocotrienols protect the heart and liver, and improve plasma glucose and lipid profiles with minimal changes in abdominal obesity in this model of human metabolic syndrome. |
| PubMedID- 21964613 | obesity is associated with the metabolic syndrome--a pathophysiologically distinct inflammatory process comprised of central obesity, insulin resistance, hypertension, and atherogenic dyslipidemia. |
| PubMedID- 20562852 | For instance, our previous studies in clockδ19/δ19 mutant mice showed that these mice are susceptible to obesity and certain features of metabolic syndrome including steatosis, adipose hypertrophy, and hyperlipidemia, due to primary defects within both hypothalamus (decreased anorexigenic peptidergic signaling), and also within liver. |
| PubMedID- 22937748 | Reported cutoff points for waist circumference and their predictive value for abdominal obesity and risk of metabolic syndrome (mets) in the chinese population [13]. |
| PubMedID- 24674634 | Results from screenings identified high obesity rates, high prevalence of metabolic syndrome, low fruit and vegetable consumption, and low use of preventive medical therapies as interventions for priority risk factors (12,13). |
| PubMedID- 25436720 | obesity also is associated with metabolic syndrome, which is a risk factor for breast cancer. |
| PubMedID- 21552555 | Genetic variants in several genes are known to influence bmi, but these mutations are rare and often cause severe monogenic syndromes with obesity [4]. |
| PubMedID- 24489111 | High-fat diet is considered to be one of the main stressors that can induce negative effects in animals such as metabolic syndrome with obesity, insulin resistance, and fatty liver. |
| PubMedID- 26537270 | Background -overweight and obesity are associated with metabolic syndrome and abdominal obesity, thereby increasing the risk of type 2 diabetes mellitus and cardiovascular diseases. |
| PubMedID- 24170999 | In our previous study, the serum bmp-4 level was associated with obesity and the presence of metabolic syndrome [4]. |
| PubMedID- 24647445 | It is well established that central obesity is the hallmark of the metabolic syndrome [3]. |
| PubMedID- 25885657 | Participants satisfying the full criteria will be classified as having metabolic syndrome; whereas those with central obesity (waist circumference >94 cm men or >80 cm women [europids, sub-saharan africans, eastern mediterranean, middle east]; >90 cm men or >80 cm women [south asians, chinese, japanese]) plus any one of: raised triglyceride level (>1.7 mm, or treatment for this); reduced hdl-cholesterol (<1.03 mm in males and <1.29 mm in females, or treatment for this); will be classified as being at risk of metabolic syndrome. |
| PubMedID- 25648310 | The aim of this study was to evaluate the relationship between platelet indices, including mean platelet volume, and abdominal obesity in patients with metabolic syndrome. |
| PubMedID- 20602679 | Background/aims: abdominal obesity is associated with metabolic syndrome and non-alcoholic fatty liver disease (nafld). |
| PubMedID- 23930111 | Background: obesity in accordance with metabolic syndrome (mets) confronts populations at the higher risk of morbidity and mortality of chronic diseases including, chronic kidney diseases (ckd). |
| PubMedID- 22360800 | Although insulin resistance is a key component of several chronic syndromes associated with obesity such as type 2 diabetes mellitus and metabolic syndrome, the involved factors and their underlying mechanisms linking excessive adiposity to insulin resistance were not completely elucidated yet [2-5]. |
| PubMedID- 25659889 | Peripheral insulin resistance is a key component of metabolic syndrome associated with obesity, dyslipidemia, hypertension, and type 2 diabetes. |
| PubMedID- 24082707 | 90. diagnosis of metabolic syndrome: abdominal obesity defined as > 35 inches in females; serum triglycerides > 150 mg/dl; bp > 130/85 mmhg; and fasting plasma glucose > 110 mg/dl. |
| PubMedID- 22041693 | obesity is associated with metabolic syndrome, a cluster of symptoms including diabetes, hyperlipidemia, hypertension and arteriosclerosis, which can cause serious health problems. |
| PubMedID- 22701354 | However, obesity is associated with metabolic syndrome characterized by alterations in glucose metabolism, lipids, and presence of hypertension [21]. |
| PubMedID- 26110103 | obesity is closely associated with metabolic syndrome, type 2 diabetes mellitus (t2dm) and cardiovascular diseases. |
| PubMedID- 23016134 | One mechanism that may explain microbial-induced obesity associated with metabolic syndrome and t2d, is endotoxemia which is characterized by excess circulating lps which triggers systemic inflammation [81,82]. |
| PubMedID- 21351667 | obesity is a part of the metabolic syndrome and an independent mortality risk factor in all age categories, however, this relation is twice as strong in individuals under fifty years of age. |
| PubMedID- 25490708 | Elevated ggt can signal liver injury generally, and non-alcoholic fatty liver disease associated with abdominal obesity and other features of the metabolic syndrome [39]. |
| PubMedID- 21187867 | Association of metabolic syndrome with obesity measures, metabolic profiles, and intake of dietary fatty acids in people of asian indian origin. |
| PubMedID- 25965509 | Fructose has been confirmed to induce several obesity-related complications associated with the metabolic syndrome. |
| PubMedID- 25688280 | Secondary aims were to examine the effects on leg strength, central obesity, and other measures of metabolic syndrome. |
| PubMedID- 26323878 | Nafld is the most common chronic liver disease in children and adults, with its prevalence closely associated with obesity and other features of the metabolic syndrome. |
| PubMedID- 22998770 | However, annotated functional classifications might provide an important reference resource to understand the pathogenesis of obesity associated with the metabolic syndrome. |
| PubMedID- 21586551 | Furthermore, severe metabolic syndrome, including obesity, dyslipidemia, hyperleptindemia, hyperglycemia, hyperinsulinemia, and glucose intolerance, was observed in high-fat-fed offspring perinatally exposed to 50 mug/kg . |
| PubMedID- 25875942 | Non-alcoholic fatty liver disease (nafld) is the most common cause of hepatic disease in western civilization [1] and is considered as a hepatic manifestation of a metabolic syndrome strongly associated with dyslipidemia, obesity, hypertension and insulin resistance[2]. |
| PubMedID- 24334572 | Objective: both increased serum levels of low-density lipoprotein cholesterol (ldlc) and metabolic syndrome (mets) are associated with obesity and have been established to be risk factors of cardiovascular disease. |
| PubMedID- 26107367 | Objectives: the aim of this study was to evaluate the efficacy of roux-en-y gastric bypass (rygb), compared with nonsurgical treatment (ns group), as an instrument for inducing remission of co-morbidities related to metabolic syndrome (mets) in patients with obesity, grades 2 and 3 (ob2,3). |
| PubMedID- 24296500 | Here, we demonstrated that subjects (n = 62) 18 to 65 years old with central obesity and components of metabolic syndrome could be grouped into two discrete groups simply by their relative abundance of prevotella spp. |
| PubMedID- 20691130 | The aim of the present study was to elucidate whether enteric-coated lf (elf) might improve visceral fat-type obesity, an underlying cause of the metabolic syndrome. |
| PubMedID- 22115311 | Interestingly, mice genetically deficient in tlr-5 have an altered gut microbiota composition that correlates with obesity and several features of the metabolic syndrome including hyperlipidemia, hypertension, and insulin resistance, which could at least in part be attributed to increased food consumption [59]. |
| PubMedID- 21799635 | The key risk factors that need to be controlled in the perimenopausal woman are hypertension, dyslipidemia, obesity, and other components of the metabolic syndrome, with the careful control of diabetes. |
| PubMedID- 22125461 | Hbot has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress. |
| PubMedID- 21688564 | Nafld as the hepatic manifestation of the metabolic syndrome (ms) is associated with obesity, diabetes mellitus and dislipidemia. |
| PubMedID- 22935215 | Inappropriately low lh and fsh concentrations are prevalent in patients with obesity and other features of metabolic syndrome (hypertension and hyperlipidemia), this prevalence may be the result of insulin resistance at the level of the gonadotropin-releasing hormone (gnrh)-secreting neuron because insulin facilitates the secretion of gnrh from neuronal cell cultures [37]. |
| PubMedID- 24111227 | Ultrasonography-based visceral fat estimation is a promising method to assess central obesity, which is associated with metabolic syndrome. |
| PubMedID- 25594826 | Sarcopenic obesity with metabolic syndrome: a newly recognized entity following living donor liver transplantation. |
| PubMedID- 22075986 | More recently, jurg introduced the critical new concept of the metabolic inflammasome, which senses metabolic stress and contributes to the onset of the metabolic syndrome associated with obesity and type 2 diabetes. |
| PubMedID- 23949560 | This attenuation may arise from causal biological correlations between insulin sensitivity, obesity, and clinical definitions of metabolic syndrome. |
| PubMedID- 21562062 | Relationships among insulin resistance, obesity, diagnosis of the metabolic syndrome and cardio-metabolic risk. |
| PubMedID- PMC4055882 | Erα undoubtedly plays a role in the estrogenic reduction in ingestive behavior—as evidenced by the fact that the erα agonist ppt decreases food intake and meal size in ovariectomized rats [45], and erα silencing in the vmn results in obesity associated with metabolic syndrome [46]. |