eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | squamous cell carcinoma of head and neck |
| Comorbidity | |squamous cell carcinoma |
| Sentences | 200 |
| PubMedID- 24393330 | Nasopharyngeal carcinoma (npc) is an epstein barr virus (ebv) associated squamous cell carcinoma of the head and neck. |
| PubMedID- 20969746 | squamous cell carcinoma of head and neck (hnscc), including the oral cavity, pharynx, and larynx, is the sixth most common cancer in the world [1]. |
| PubMedID- 22402942 | Similarly, the combination has minimal clinical activity in patients with advanced upper gastrointestinal cancers [25] and recurrent advanced squamous cell carcinoma of the head and neck [26]. |
| PubMedID- 22681652 | squamous cell carcinoma of the head and neck region are the most frequently diagnosed cancers among albinos in our environment. |
| PubMedID- 22723937 | Therefore, this mirna has been found to be frequently silenced by methylation in several cancers including colorectal cancer [45], gastric cancer [46], uveal melanoma [47], oral cancer [48], glioblastoma multiforme [49] and squamous cell carcinoma of the head and neck [50], [51], and potentially acts as a tumor suppressor microrna in these tumors. |
| PubMedID- 21184685 | The 91 investigated patients with histologically confirmed squamous cell carcinoma of the head and neck (scchn) comprised 15 women and 76 men. |
| PubMedID- 24386210 | Nuclear nrf2 expression has been reported at different frequencies in other epithelial tumors, including squamous cell carcinoma of the head and neck [17], [18] and lung cancer. |
| PubMedID- 24116137 | In addition, it correlated with poor prognosis in several hematopoietic malignancies [10,11], gastric cancer [12] and squamous cell carcinoma of the head and neck [13]. |
| PubMedID- 22537712 | The second study reported costs during the first 6 months after diagnoses for patients aged 35 and older with commercial insurance or medicare with advanced squamous cell carcinoma of the head and neck[5]. |
| PubMedID- 24591744 | In contrast, decreased cathepsin h expression has also been reported in squamous cell carcinoma of the head and neck[44]. |
| PubMedID- 21776391 | squamous cell carcinoma of the head and neck (hnscc) is a heterogeneous disease that includes tumors arising from the mucosal epithelial surface of the oral cavity, oropharynx, hypopharynx, and larynx. |
| PubMedID- 25029652 | squamous cell carcinoma of the head and neck is one of the most common types of cancerworldwide, and the prevalence of heavy smoking is high in this group. |
| PubMedID- 20822525 | N-cam expression has been reported in bile duct cancer [70], squamous cell carcinoma of head and neck [71], prostate cancer [72], and malignancies of the salivary gland [73]. |
| PubMedID- 25395947 | Previous studies have reported that serum pge-2 was elevated in squamous cell carcinoma of the head and neck [23, 24] and of the esophagus [25]. |
| PubMedID- 21822357 | Egfr mab therapies are effective for treating squamous cell carcinoma of the head and neck and are also being evaluated in other hpv-associated tumors [29]. |
| PubMedID- 23976970 | Hb: hospital-based; pb: population-based; pcr-rflp: polymerase chain reaction-restricted fligment length polymorphism; hwe: hardy-winberg equibrilium; na: not available; nc: nasopharyngeal carcinoma; ec: esophageal carcinoma; lc: lung cancer; bc: breast cancer; scchn: squamous cell carcinoma of the head and neck; lscc: laryngeal squamous cell carcinoma; hcc: hepatocellular carcinoma; a: mean + standard devation; † the study by lu j [18] was treated as two studies, lu ja: test set, lu jb: validation set;‡ in the study by naidu r [20], each population was considered as a study. |
| PubMedID- 24364026 | squamous cell carcinoma of the head and neck (hnscc) is the sixth most-common cancer in the developed world [1, 2] and represents a therapeutically-challenging, behaviourally-heterogenous category of disease. |
| PubMedID- 20565895 | squamous cell carcinoma of the head and neck (scchn) is considered the sixth most common cancer in the world [1]. |
| PubMedID- 25625305 | However, when compared hpv-positive with hpv-negative squamous cell carcinoma of the head and neck cell lines, this mirna was downregulated in the presence of hpv-16 dna [35]. |
| PubMedID- 22546534 | [22] reported a study which included 208 patients with advanced squamous cell carcinoma of the head and neck following co2 laser resection, patients were given postoperative radiotherapy. |
| PubMedID- 24616882 | Imrt, intensity modulated radiotherapy; nsclc, non-small cell lung cancer; rt, radiotherapy; msi, microsatellite instability; crpc, castrate resistant prostate cancer; sclc, small cell lung cancer; gbm, glioblastoma multiforme; dpg, diffuse pontine glioma; hnscc, squamous cell carcinoma of the head and neck; 5-fu, 5-fluorouracil; pld, pegylated liposomal doxorubicin. |
| PubMedID- 24421989 | It is a well established oncogene that has beendemonstrated to promote cell proliferation and suppresses apoptosis identified invarious cancers including squamous cell carcinoma of the head and neck/oral cavity.once it was realized that microrna-21 transfected cells had a growth advantage overnormal controls the potential targets were investigated. |
| PubMedID- 22674532 | We investigated risk factors for superficial hnscc in patients with esophageal squamous cell carcinoma (escc). |
| PubMedID- 22295201 | In a phase i study on 27 patients with pretreated (2nd- or 3rd- line treatment) stage iv cancer (19 pancreatic carcinoma, 6 renal cell carcinoma, 1 gastric cancer, and 1 squamous cell carcinoma of the head and neck scchn), lipoplatin dose was escalated from 25 to 125 mg/m2, and it was administered as an 8-hour infusion diluted in 1 l 5% dextrose, repeated every 2 weeks without need for pre or posthydration. |
| PubMedID- 21660277 | squamous cell carcinoma of the head and neck is diagnosed annually in approximately 40,000 patients in the united states [1]. |
| PubMedID- 24599075 | squamous cell carcinoma of the head and neck (scchn) is the 6th most common malignancy worldwide [8] with a worldwide incidence of at least 500,000 and will be diagnosed in approximately 45,000 new patients in the united states this year [9]. |
| PubMedID- 21461387 | This paper examines the diagnosis, pathology, clinical course, and treatment options for cutaneous squamous cell carcinoma of the head and neck. |
| PubMedID- 21085979 | squamous cell carcinoma of the head and neck (scchn) has been shown to express a number of chemokines, and their receptors, which may e.g., promote chemotherapy resistance (muller et al. |
| PubMedID- 24587773 | squamous cell carcinoma of the head and neck (hnscc) is primarily a disease of older adults, occurring most frequently in patients older than age 45. epidemiological studies over last 20 years have shown a steady rise in the incidence of these cancers in younger adults (age 18–45 years), especially in cancers of the oropharynx and oral cavity.1,2 the predilection for these particular subsites vs. other sites such as the larynx or the hypopharynx remains unclear. |
| PubMedID- 22913768 | We also note, however, that this code has been employed in several single technology appraisals (stas) and evidence review group’s (erg) reports to cost chemotherapy-related febrile neutropenia among adults with her2-negative metastatic breast cancer, adults with chronic lymphocytic leukemia, adults with metastatic prostate cancer, and adults with squamous cell carcinoma of the head and neck, respectively [15-18]. |
| PubMedID- 24358243 | Used the same uv-vis diffuse reflectance spectroscopy system in an in vivo clinical study in which 21 patients with mucosal squamous cell carcinoma of the head and neck were evaluated [34]. |
| PubMedID- 24457040 | We conducted a comprehensive search in pubmed, cochrane library and chinese biomedical literature database (cbm), covering all articles published up to oct 31, 2013, using the following terms: “rad51” and “polymorphism” and “(squamous cell carcinoma of the head and neck) or (colorectal cancer) or (ovarian cancer) or (acute leukaemia)”. |
| PubMedID- 24516537 | squamous cell carcinoma of the head and neck (scchn), including the oral cavity, nasopharynx, hypopharynx, larynx and tongue, is the 5th most common cancer worldwide and represents 4% of all diagnosed neoplasms [1]. |
| PubMedID- 25980577 | Also, a patient with squamous cell carcinoma of head and neck with wt pik3ca and an egfr exon 21 mutation (h835l) in an initial resected tumor was found to have a pik3ca e545k mutation (0.05%) in cfdna collected after progressive disease following 3 months of cetuximab, carboplatin and paclitaxel treatment. |
| PubMedID- 22472064 | Long-term disease control for patients with advanced squamous cell carcinoma of the head and neck (scchn) is still challenging. |
| PubMedID- 22704532 | All patients had a squamous cell carcinoma of the head and neck, with 19 oropharyngeal tumors (66%), 6 laryngeal (21%), 3 nasopharynx (10%) and 1 oral cavity (3%). |
| PubMedID- 20587061 | squamous cell carcinoma of the head and neck (hnscc) has an estimated incidence of 35,310 new cases in 2008 in the united states, with an expected 7590 deaths due to these cancers. |
| PubMedID- PMC4466650 | squamous cell carcinoma of the head and neck (hnscc) is the sixth most prevalent cancer in the world [1]. |
| PubMedID- 25927305 | Cyp2c19 pm status interacts significantly with environmental risk factors in modifying susceptibility to squamous cell carcinoma of the head and neck [30]. |
| PubMedID- 25874882 | It was reported that krt17 could be a tumor marker in squamous cell carcinoma of head and neck and breast cancers [36,37]. |
| PubMedID- 20713318 | In our unpublished experience on 131 patients followed up for squamous cell carcinoma of the head and neck, the 40 recurrences appeared bright on b-1000 images, the mean adc value of recurrences was comparable with that of primary tumors (0.97 × 10−3 mm2/s vs 0.89 × 10−3 mm2/s, p = ns); conversely, mature scar lesions invariably appeared dark as background normal tissues on b1000 images (fig. |
| PubMedID- 24013949 | Cancer types were classified as breast cancer, squamous cancer (squamous cell carcinoma of head and neck, and laryngeal squamous cell carcinoma), and other cancers (nasopharyngeal carcinoma, esophageal carcinoma, lung cancer, and hepatocellular carcinoma). |
| PubMedID- 24514166 | Hspb5 was also reported to be downregulated in anaplastic thyroid carcinomas [66], nasopharyngeal carcinomas [67], cutaneous squamous cell carcinoma of the head and neck with clinical perineural invasion [68], oral cancer [69,70] as well as human ovarian cancer [71] and testicular tumors [63]. |
| PubMedID- 25993495 | For some cancers in particular (e.g., brain tumors such as glioblastoma multiforme and squamous cell carcinoma of the head and neck – scchn) it is a cause of severe morbidity and can be life-threatening even in the absence of distant metastases. |
| PubMedID- 25909285 | In patients with recurrent or metastatic squamous cell carcinoma of the head and neck, stable disease with minor tumor shrinkage was found in half of patients received foretinib treatment and a combinational therapy with targeted agents or cytotixic chemotherapy was suggested [30]. |
| PubMedID- 20335368 | For patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (scchn), platinum has been an integral part of palliative care for about the past 30 years. |
| PubMedID- 22408457 | The us nih repository for clinical trials reports some trials involving epigenetic-based drugs in head and neck cancer treatment: azacitidine and cisplatin have been tested in combined chemotherapy in advanced, recurrent and metastatic squamous cell carcinoma of head and neck but no data are available to date about the outcome of the study [154]. |
| PubMedID- 24603722 | In our meta-analysis, the association between rs560191 polymorphism and other cancer types including cervical cancer, breast cancer and squamous cell carcinoma of the head and neck was also analyzed. |
| PubMedID- 24130817 | Owing to this characteristic histology and the abundant lymphatic network in nasopharynx, npc exhibits greater regional and distant metastasis than other squamous cell carcinoma of head and neck (scchn). |
| PubMedID- 24495306 | Metalloproteinases are particular important in oral cancer progression, and squamous cell carcinoma of head and neck has been classified as the fifth most common type of cancer in the world [9]. |