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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease severe combined immunodeficiency
Comorbidity |severe combined immunodeficiency
Sentences 65
PubMedID- 24466340 Lastly, mutations of dna-pkcs cause severe combined immunodeficiency in mice [17], [18], [19], [20].
PubMedID- 25550434 Female severe combined immunodeficiency (scid) mice (charles river laboratory) in the +dox group were switched to 400 ppm doxycycline diet (harlan) 3 days prior to implant, while animals in the −dox group were maintained on standard mouse diet.
PubMedID- 24487407 Five- to six-week-old cb-17 severe combined immunodeficiency (scid) male mice (charles river laboratories international, wilmington, ma, usa) had xenograft tumors induced by injecting 1×106 pc3 cells suspended in 50 μl of pbs subcutaneously in the upper hind legs of the animals.
PubMedID- 25944695 Six- to eight-week-old male cb.17/severe combined immunodeficiency disease (scid) mice were inoculated subcutaneously with 5 × 106 oci-ly7 tumor cells in 0.1 ml pbs for tumor development.
PubMedID- 22469436 A 12-year-old girl with severe combined immunodeficiency was admitted to the freiburg university medical center, germany, in november 2009 for treatment of progressive respiratory problems and cytomegalovirus (cmv) disease.
PubMedID- 23264026 severe combined immunodeficiency (scid), characterized by extremely low or absent t cell production, defective t cell function and absent antibody responses, can be caused by defects in any of several genes and if untreated leads to early death due to infections [1, 2].
PubMedID- 22111066 Three severe combined immunodeficiency (scid) mice (males, 6 weeks old) were injected with a suspension of 1×109 cells/ml in the back; however, no tumor formation was observed after 6 weeks.
PubMedID- 21994645 Approval of adagen® (pegademase) for the treatment of severe combined immunodeficiency disease (scid) by the u.s. fda in the early 1990s illustrated the potential for pegylation to significantly impact modern therapeutics.
PubMedID- 21544519 severe combined immunodeficiency (scid) is part of the differential diagnosis of cd40l deficiency (van der burg m, gennery a, the expanding spectrum of severe combined immunodeficiency, ejp in press), but in contrast to most cases of scid, analysis of lymphocyte subpopulation in pad patients will show normal t cell counts.
PubMedID- 20594324 5-6 weeks old female severe combined immunodeficiency mice (scid) mice were obtained from harlan laboratory (harlan laboratories, inc, indianapolis, in) and maintained under pathogen free conditions in a temperature and humidity controlled animal care facility with a 12 hours light dark cycle.
PubMedID- 24069355 Thus, for the first time we present t-b-nk+ severe combined immunodeficiency (scid) phenotype after spontaneously occurring modification of artemis gene in mice.
PubMedID- 24497838 severe combined immunodeficiency (scid) beige mice were maintained in a pathogen–free environment under controlled conditions of light and humidity.
PubMedID- 24454751 Nonobese diabetic/severe combined immunodeficiency (nod/scid) mice (sankyo-lab service, tsukuba, japan) were bred and maintained in accordance with our institutional guidelines for the use of laboratory animals.
PubMedID- 24740260 Cells with deletion of any of these nhej components show severe combined immunodeficiency (scid) due to defects in assembling variable (diverse) joining (v(d)j) segments of antigens, genetic instability and hypersensitivity to dsb inducing agents [5]–[9].
PubMedID- 21701688 Briefly, female, severe combined immunodeficiency (scid) mice (17–20 g, 4–6 weeks old) were bred in house and maintained throughout in specific pathogen-free (spf) isolators.

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