eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | portal hypertension |
| Comorbidity | |cirrhosis |
| Sentences | 135 |
| PubMedID- 23999681 | Combined biliovascular injuries, segmental atrophy, and secondary biliary cirrhosis with portal hypertension are special circumstances which are best managed by a multidisciplinary team at an experienced center for optimal outcomes. |
| PubMedID- 25969457 | Varices are known to develop in patients having cirrhosis with portal hypertension. |
| PubMedID- 26192141 | The management of portal hypertension in cirrhosis has evolved over time, leading to improvements in the care and survival of patients with varices and variceal hemorrhage, particularly in patients who achieve a significant reduction in portal pressure. |
| PubMedID- 21485513 | Conclusion: the results indicated the effectiveness of therapy with flavonoids hesperidin with diasmin at portal hypertension in patients with alcoholic cirrhosis, which allows to include them in the complex treatment of medicamental prophylaxis of variceal bleeding. |
| PubMedID- 23983486 | His medical history was significant for alcoholic cirrhosis with portal hypertension, splenomegaly, hypersplenism, and ascites. |
| PubMedID- 26357616 | Liver damage can be progressive, leading to cirrhosis, complications of portal hypertension, and liver-related death, and, therefore, must be accurately identified. |
| PubMedID- 21701671 | She was a known case of cryptogenic liver cirrhosis with portal hypertension. |
| PubMedID- 23056756 | Liver involvement might progress toward the cirrhosis, accompanied with portal hypertension, ascites and esophageal varicosities, but these manifestations were otherwise mainly absent in our group[5, 7, 10, 20]. |
| PubMedID- 22811587 | Hepatic manifestations were first described by klatskin and yesner in 1950 and include granulomatous hepatitis, cholestasis, cirrhosis, portal fibrosis leading to presinusoidal portal hypertension, budd-chiari syndrome, adult ductopenia-like syndrome, and rarely chronic granulomatous sclerosing cholangitis with ductal strictures [55–57]. |
| PubMedID- 25606379 | Additionally, the authors reported that determination of low pon1 activity may serve as a useful additional test in assessing liver diseases including acute viral hepatitis b, chronic alcoholic hepatitis, cirrhosis with portal hypertension, hcv-related cirrhosis, hereditary hemochromatosis, and non-alcoholic fatty liver disease (nafld) (keskin et al., 2009; matineli et al., 2013; mogarekar and talekar, 2013). |
| PubMedID- 23547461 | [the protective effect of n-acetylcysteine magnesium against liver cirrhosis with portal hypertension in rat]. |
| PubMedID- 24350068 | Liver cirrhosis causes 90% of portal hypertension in the western world, which leads to the development of porto-systemic collaterals, this in turn triggers the formation of the lower esophageal and gastric cardiac varices. |
| PubMedID- 24459641 | Lsm could be a non-invasive method to predict clinically significant and severe portal hypertension in patients with liver cirrhosis in korea. |
| PubMedID- 21176011 | Although poph is most commonly observed in the setting of cirrhosis, patients with non-cirrhotic portal hypertension are also at risk of developing the disorder. |
| PubMedID- 23997080 | An evaluation revealed hepatic cirrhosis with portal hypertension, secondary to chronic budd-chiari syndrome. |
| PubMedID- 21831314 | Sixty-seven patients were not enrolled in the study for the following reasons: (1)cirrhosis and evidence of portal hypertension (n = 17); (2) declined staging procedures and preferred to wait for new hcv therapies (n = 15); (3) omission of survey completion during early months on study implementation (n = 13); (4) declined any medical treatment or evaluation (n = 9); (5) hcv antibody positive and hcv rna negative and did not need hcv therapy (n = 7); and (6) transferring care to a different city and clinical staging could not be completed (n = 6). |
| PubMedID- 20652243 | Four patients underwent splenectomy because of liver cirrhosis with portal hypertension and gastroesophageal variceal bleeding. |
| PubMedID- 20704762 | cirrhosis leads to portal hypertension of varying extents. |
| PubMedID- 25789194 | Her liver disease progressed to cirrhosis and was complicated by portal hypertension, refractory ascites, and recurrent episodes of sbp. |
| PubMedID- 21371340 | In this case report, we describe the changes that occurred in the gastric and jejunal mucosa in a cirrhosis patient with portal hypertension with ce, and we report the positive effect of a tips placement. |
| PubMedID- 25457205 | Background & aims: inflammation, collagen deposition and tissue remodelling are involved in the pathogenesis and complications of cirrhosis with portal hypertension. |
| PubMedID- 21802316 | Purpose: to develop a clinically relevant porcine model of liver cirrhosis with portal hypertension by means of hepatic transarterial embolization. |
| PubMedID- 24324910 | For a definitive diagnosis of hps, patients must meet three criteria: (1) room air po2 < 80 mmhg or a-a gradient > 15 mmhg, (2) evidence of intrapulmonary shunting (typically on contrast-enhanced echocardiography or a lung perfusion scan), and (3) portal hypertension with or without cirrhosis [1]. |
| PubMedID- 25912838 | However, it is not clear to what extent the progression of hepatitis c is modified once patients develop cirrhosis with severe portal hypertension (csph) (hvpg >/= 10 mm hg). |
| PubMedID- 24439187 | The causes of ev included portal hypertension with cirrhosis in 52 cases (42 of hepatitis as dominant, 5 of alcoholic, 3 of biliary). |
| PubMedID- 25649410 | The peripheral arterial vasodilation theory is the most widely accepted explanation for the pathophysiology of hrs (figure 1) [1], which proposes that splanchnic vasodilation that occurs as a consequence of portal hypertension with cirrhosis is the inciting factor for the development of hrs. |
| PubMedID- 20339175 | Levels of globulins significantly increased in cirrhosis with portal hypertension (p<0.001). |
| PubMedID- 24678881 | Clinical studies showed that the markers bgm, elastin mmp-generated neo-epitope fragment (elm) c1m, c3m, c4m c5m, collagen type vi mmp-generated neo-epitope fragment (c6m), pro-c3 and p4np 7s were associated with portal hypertension in patients with cirrhosis, reflecting the degree of liver dysfunction[123]. |
| PubMedID- 25469784 | Purpose: to prospectively compare the technical success rate and accuracy of shear-wave elastography (swe) and transient elastography (te) for the detection of clinically significant portal hypertension (ph) in patients with advanced cirrhosis who are undergoing hepatic vein pressure gradient (hvpg) measurements. |
| PubMedID- 22568417 | This study considers a possible role of fibrosis evaluation by transient elastography (fibroscan((r))) and its correlation with portal hypertension in patients with cirrhosis, and discusses the use of this technique in planning therapeutic options in patients with hepatocellular carcinoma (hcc). |
| PubMedID- 24587847 | Patients with nash have the potential to develop fibrosis and cirrhosis leading to portal hypertension, liver decompensation, and hepatocellular carcinoma [4]. |
| PubMedID- 20113491 | In addition, although splenomegaly should be expected in severe cirrhosis with portal hypertension, there were no statistical differences in splenic area among the three groups analyzed, indicating that splenomegaly was not a prominent feature in our study of cirrhotic rats. |
| PubMedID- 20562900 | Hepatic fibrosis and its endstage cirrhosis, with life-threatening complications of portal hypertension and liver failure, have become major public health problems1. |
| PubMedID- 21806953 | Conclusions: treating portal hypertension by tips in patients with advanced cirrhosis and without he had no effect on their cbf and seemed not to entail a risk of cerebral hypoperfusion. |
| PubMedID- 21606920 | The experimental study of liver cirrhosis with portal hypertension syndrome, modeled in 38 dogs, has been performed. |
| PubMedID- 24889902 | Phg, by definition, requires the presence of portal hypertension, with or without cirrhosis, whereas gave requires neither cirrhosis nor portal hypertension. |
| PubMedID- 25263269 | Successful pregnancy is possible in well-compensated cirrhosis or with mild portal hypertension, although the maternal and foetal mortality and morbidity are higher than in the general population. |
| PubMedID- 23228021 | Further investigations revealed cirrhosis with portal hypertension. |
| PubMedID- 25374709 | In view of a normal serology, the patient's diagnosis was alcohol-related cirrhosis with portal hypertension with portal colopathy with massive lower gi bleed. |
| PubMedID- 24436365 | Main outcome measurements: (1) incidence of cholestasis, (2) identification of risk factors for cholestasis, (3) association between the presence of cholestasis and mi and the development of clinically significant cf-associated liver disease (cfld) defined as multilobular cirrhosis with portal hypertension. |
| PubMedID- 25454305 | Portal vein thrombosis (pvt) is a rare event in the general medical setting that commonly complicates cirrhosis with portal hypertension, and can also occur with liver tumors. |
| PubMedID- 21340026 | However, sorafenib can lead to endothelial injury and promote vascular leakage, and is not approved for patients with portal hypertension complicated by cirrhosis of the liver and advanced hcc (child–pugh class b to c), even in the absence of gastrointestinal bleeding. |
| PubMedID- 21116340 | Patients with cirrhosis and signs of portal hypertension (platelet count <140,000/mm3) should have screening endoscopy. |
| PubMedID- 23559324 | Olt was performed at the age of 7 years, due to liver cirrhosis with portal hypertension, in the absence of neurological lesions and an almost-normal brain mri. |
| PubMedID- 22248963 | Caput medusae and palmar erythema are cardinal signs in cirrhosis of liver with portal hypertension. |
| PubMedID- 24099470 | Background: the hepatic venous pressure gradient (hvpg) is an invasive, but important diagnostic and prognostic marker in cirrhosis with portal hypertension (pht). |
| PubMedID- 26385087 | Thus, jak2 inhibitors, already in clinical use for other indications, might be a new approach to treat cirrhosis with portal hypertension. |
| PubMedID- 21213113 | Background: in patients with cirrhosis the onset of clinically significant portal hypertension (csph; i.e., hepatic venous pressure gradient (hvpg) >/= 10 mmhg) is associated with an increased risk of complications. |
| PubMedID- 24400086 | The hemodynamic alteration of portal hypertension in patients with liver cirrhosis contributes to most of the clinical manifestations of the disease: gastrointestinal bleeding, hepatic encephalopathy, ascites and renal failure. |
| PubMedID- 24851522 | Aim: cirrhosis with portal hypertension (pht) may be associated with increased small intestinal permeability (sip), predisposing to malnutrition and bacterial translocation causing septicaemia, endotoxaemia and spontaneous bacterial peritonitis. |