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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease polycystic ovary syndrome
Comorbidity |hyperandrogenism
Sentences 72
PubMedID- 20663984 polycystic ovary syndrome (pcos) is associated with hyperandrogenism and insulin resistance, possibly reflecting defects in skeletal muscle and adipocyte insulin signaling.
PubMedID- 23876972 Nevertheless, rad54b may contribute to hyperandrogenism in pcos patients.
PubMedID- 21812961 Women experiencing hyperandrogenism associated with polycystic ovarian syndrome (pcos) [6,7] and preeclampsia [8-10] have a higher-than-normal prevalence of small-for-gestational age deliveries [11-15].
PubMedID- 24116069 hyperandrogenism in pcos, and inverse correlation between androgen receptor (ar) cag numbers and ar function, led us to hypothesize that cag length variations may affect pcos risk.
PubMedID- 24428207 Also metabolic characteristics, fasting insulin and homa-ir were comparable in pcos subjects with hyperandrogenism and the nonhyperandrogenic phenotype (anovu + pco).
PubMedID- 22112520 Loss of the ovarian apoptotic mechanism has been reported to account pcos appearance [11,30,31], with hyperandrogenism as one of the proposed mechanisms affecting the balance between the ovarian expression of pro and anti-apoptotic proteins [32].
PubMedID- 21577021 Presence of oligo- and/or anovulation (anov) and hyperandrogenemia and/or hyperandrogenism (ha) with or without polycystic ovaries (pco)) appear to have a more adverse metabolic profile than patients diagnosed with the additional criteria introduced in 2003 (i.e.
PubMedID- 24695544 In human cultured theca cells, recombinant resistin triggered 17α-hydroxylase activity, a marker of ovarian hyperandrogenism in women with pcos [64].
PubMedID- 23812344 Background: polycystic ovary syndrome (pcos) is associated with hyperandrogenism and an increased risk of type 2 diabetes and cardiovascular disease.
PubMedID- 25554608 hyperandrogenism in pcos may increase the risk of nafld indirectly by obesity, insulin resistance, and directly by the hepatotoxic effect.
PubMedID- 21899727 Whereas metformin alone did not significantly reduce the free androgen index in obese adolescents, the combination of metformin and flutamide was as effective as e2-p combination pills in reducing the hyperandrogenism associated with pcos [133].
PubMedID- 21427116 In addition, pcos patients with or without hyperandrogenism, and pcos patients with persisting and resolved pcos all had lower matsuda insulin sensitivity index and increased insulinogenic index in comparison with controls.
PubMedID- 22696150 Although bmi and follicle counts were higher in the african american cohort this cannot be explained by higher rates of pcos, as women with pcos and hyperandrogenism, as well as other reproductive disorders were excluded.
PubMedID- 24713888 The assay may provide greater ability to distinguish ovarian hyperandrogenism in women with pcos from other disorders in which adrenal steroidogenesis is compromised, such as in nonclassic congenital adrenal hyperplasia.
PubMedID- 22035022 Background: obesity, insulin resistance and hyperandrogenism, crucial parameters of polycystic ovary syndrome (pcos) play significant pathophysiological roles in lipidemic aberrations associated within the syndrome.
PubMedID- 21190873 Among them, 42 cases who had a definitive diagnosis of pcos with hyperandrogenism based on rotterdam diagnostic criteria were recruited for the study and other causes of hyperandrogenemia had been excluded.
PubMedID- 24901345 Prevalence of metabolic syndrome is higher among non-obese pcos women with hyperandrogenism and menstrual irregularity in korea.
PubMedID- 21521255 All probands had pcos, defined by symptoms of anovulation and/or hyperandrogenism with polycystic ovaries on ultrasound.
PubMedID- 24615662 Normalization of lh secretion (and perhaps the consequent hyperandrogenism) in pcos may promote folliculogenesis and ovulation.
PubMedID- 25514100 Context: adrenal hyperandrogenism affects approximately 25% of polycystic ovary syndrome (pcos) patients but its relation to obesity is not totally understood.
PubMedID- 23717068 polycystic ovaries are likely associated with ovarian hyperandrogenism, hyperinsulinemia, and altered intraovarian paracrine signaling [3,4].
PubMedID- 22737168 Both of central obesity and hyperandrogenism in pcos aggravate insulin resistance which promotes incidence of diabetes mellitus.

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