eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | monoclonal gammopathy of uncertain significance |
| Comorbidity | |monoclonal gammopathy of undetermined significance |
| Sentences | 92 |
| PubMedID- 25706753 | However, their subjects included patients with not only asymptomatic myeloma, but also monoclonal gammopathy of undetermined significance (mgus), which is a common premalignant plasma cell disorder, raising concern about the skewed diagnostic performance of variables in differentiating disease status. |
| PubMedID- 25615546 | Multiple myeloma (mm) is a pc malignancy that is nearly always preceded by monoclonal gammopathy of undetermined significance (mgus) [11]. |
| PubMedID- 24813251 | Moreover, in various datasets there was a consistent, significant reduction in yap1 expression levels, progressing from normal plasma cells to monoclonal gammopathy of undetermined significance (mgus) to mm (fig. |
| PubMedID- 24779000 | Either clinical and population-screening studies indicate that mbl, mimicking what observed in monoclonal gammopathy of undetermined significance (mgus), display the same chromosomal abnormalities and a mutated igvh status usually seen in low-risk cll [3,11,13,16-18]. |
| PubMedID- 25794164 | monoclonal gammopathy of undetermined significance (mgus) is a premalignant stage that can progress to mm, a malignant plasma cell neoplasia [1,2]. |
| PubMedID- 20846389 | It has been shown that primary myeloma cells from osteolytic mm patients significantly overexpressed the wnt inhibitor dkk-1 in comparison with the plasma cells from patients with monoclonal gammopathy of undetermined significance (mgus) and normal plasma cells. |
| PubMedID- 22303318 | Multiple myeloma develops from a benign condition called monoclonal gammopathy of undetermined significance (mgus) (weiss et al., 2009). |
| PubMedID- 26474569 | Reports showed that the underlying monoclonal gammopathy of undetermined significance (mgus) progresses to mm, resulting in the co-existence of mgus and aml, particularly in elderly patients [9]. |
| PubMedID- 22481966 | Individuals with multiple myeloma must be distinguished from those with monoclonal gammopathy of undetermined significance (mgus) (<10% plasma cells in bone marrow, low levels of m-protein (<3 g/dl), and no osteolytic lesion), amyloidosis, or other lymphoproliferative disorders with paraproteinemia [36]. |
| PubMedID- PMC3002697 | In the years preceding mm diagnosis, a small monoclonal ig develops that may be detectable upon serum protein electrophoresis, resulting in a premalignant condition known as monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 24391641 | monoclonal gammopathy of undetermined significance (mgus) is a common disorder of aging and a precursor lesion to multiple myeloma (mm). |
| PubMedID- 24086494 | Samples and biopsies from normal bone marrows, 26 mcl, 5 monoclonal gammopathy of undetermined significance (mgus) and 20 mm patients' were processed and used after achievement of written informed consent according to the declaration of helsinki. |
| PubMedID- 24314019 | Nearly all mm patients derive from asymptomatic monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 25949496 | monoclonal gammopathy of undetermined significance: a contraindication for living kidney donation? |
| PubMedID- 24534189 | The aforementioned experiments reveal that tolerance to nucleic acid-sensing tlrs is disrupted by a somatic mutation in myd88 that is very frequently found in the benign disorder, igm monoclonal gammopathy of undetermined significance, and in a range of b cell malignancies. |
| PubMedID- 24839982 | Interestingly, several studies indicate that monoclonal gammopathy of undetermined significance (mgus) and non-active mm (smoldering mm) represent the avascular phase of pc malignancies, while active intramedullary mm is the vascular phase of the disease. |
| PubMedID- 22522905 | Of relevance to this study, others have used ighv sequence analysis to better understand the relationship between mm and its known premalignant condition monoclonal gammopathy of undetermined significance (mgus) [23, 24] and have shown that while there is evidence for intraclonal heterogeneity in mgus, mm pcs are homogeneous [17, 25-27]. |
| PubMedID- 21436884 | Samples contained 8 brain autopsy tissues from 6 patients (6 from 5 hiv-positive patients with pml, 2 from a patient with chronic lymphocytic leukemia(cll)), 62 csf samples from 59 patients (30 from 29 hiv-positive patients with pml, 12 from 12 hiv-negative patients with pml, 6 from 6 hiv-positive patients, 10 from 10 patients immunosuppressed by other diseases and 2 from 2 ms patients), 13 whole blood samples from 13 patients (2 from 2 hiv-negative patients with pml, 2 from 2 hiv-positive lymphoma patients, 3 from lymphoma patients, 2 from 2 patients with monoclonal gammopathy of undetermined significance(mgus), 1 from a patient with thrombocytosis, 1 from a hiv-positive patient with anemia, 1 from a patient with leshmaniasis, 1 from a cll patient), 68 pbmc samples from 49 patients (14 from 14 hiv-positive patients with pml, 10 from 10 hiv-negative patients with pml, 7 from 7 hiv-positive patients, 19 from ms patients prior to natalizumab treatment, 18 from ms patients after natalizumab treatment). |
| PubMedID- 24355943 | Mm is preceded by a premalignant condition termed monoclonal gammopathy of undetermined significance (mgus) [5]. |
| PubMedID- 24489445 | To this aim, we analyzed the signals implemented by monoclonal antibodies (mab) ligation in peripheral blood mononuclear cells (pbmc) obtained from mm patients and compared to benign monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 22348393 | In many instances mm is preceded by monoclonal gammopathy of undetermined significance (mgus), a pre-malignant state without clinical symptoms of malignancy (1). |
| PubMedID- 22399147 | The remaining patient had an igg monoclonal gammopathy of undetermined significance and a progressive and painful polyneuropathy for which she was treated with sct. |
| PubMedID- 21760829 | [4] light chain al can be associated with monoclonal gammopathy of undetermined significance (mgus), waldenstrom's macroglobulinemia, and lymphoplasmacytic disorders. |
| PubMedID- 22826794 | Lane 2: negative control (patient with monoclonal gammopathy of undetermined significance). |
| PubMedID- 22429443 | Ferritin levels were increased (> 500 μg/dl) in 165 (46.1%) patients; 322 (90.2%) had hypergammaglobulinemia (> 1.5 g/dl); and 61 adult patients (> 18 years old) (17.1%) had monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 23074671 | monoclonal gammopathy of undetermined significance (mgus) is a plasma cell proliferative disorder characterized by a plasma cell level of less than 10% in the bone marrow, a monoclonal paraprotein band less than 30 g/l, and no end organ damage (crab—hypercalcemia, renal insufficiency, anemia, and bone lesions) [14]. |
| PubMedID- 21415944 | monoclonal gammopathy of undetermined significance (mgus), as defined by the international myeloma working group, is a disorder characterized by a prominent monoclonal protein identified by serum electrophoresis. |
| PubMedID- 22189730 | Patients diagnosed with monoclonal gammopathy of undetermined significance or poems (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) syndrome were excluded from this study. |
| PubMedID- PMC4044641 | Some patients may show a slow progressive evolution from monoclonal gammopathy of undetermined significance while others may be associated with features of high clonal aggressiveness such as plasma cell leukemia or extramedullary plasmacytomas. |
| PubMedID- 24527207 | According to uncontrolled studies [123–125] rituximab might be helpful in cidp associated with hematological disorders such as monoclonal gammopathy of undetermined significance and multiple myeloma, but a very recent rct [126] on 54 patients with anti-mag followed up for one year has shown no significant benefit from rituximab compared to placebo in terms of changes in the iss score [78]. |
| PubMedID- 24349810 | Differential diagnosis included monoclonal gammopathy of undetermined significance (mgus) [2], solitary plasmacytoma, multiple myeloma, waldenstrom macroglobulinemia, primary amyloidosis, and cryoglobulinemia. |
| PubMedID- 20671999 | Patients with monoclonal gammopathy of undetermined significance and multiple myeloma are at increased risk of venous thromboembolic events with a baseline prevalence of approximately 10% [56]. |
| PubMedID- 21415967 | Individuals with plasma cell reactions to connective tissue disorders, liver disease, metastatic carcinoma or chronic infections were not included, nor patients with monoclonal gammopathy of undetermined significance,3 smoldering multiple myeloma, solitary plasmacytoma or plasma cell leukemia. |
| PubMedID- 25838912 | A 64-year-old female patient with scleroderma, monoclonal gammopathy of undetermined significance, chronic thrush, and kidney failure was admitted to icu with confusion, high grade fevers and 20 lbs weight loss. |
| PubMedID- 20485371 | Eight patients had coexisting hematological disorders including two with chronic lymphocytic leukemia, two monoclonal gammopathy of undetermined significance, two multiple myeloma and one paroxysmal nocturnal hemoglobinuria. |
| PubMedID- 22848499 | Mgus: monoclonal gammopathy of undetermined significance. |
| PubMedID- 20602755 | In patients with monoclonal gammopathy of undetermined significance, the risk of progression to multiple myeloma at 25 year follow-up is around 30% [24]. |
| PubMedID- 24363850 | Any patient presenting with cardiomyopathy with preserved systolic function, heavy albuminuria, an unexplained sensorimotor peripheral neuropathy, hepatomegaly, or atypical monoclonal gammopathy of undetermined significance or myeloma should be suspected of having al amyloidosis [5]. |
| PubMedID- 22812447 | Finally, the diagnosis was widespread cryoglobulinemic vasculitis with skin, lung, and kidney involvement secondary to monoclonal gammopathy of undetermined significance associated with sjögren’s syndrome. |
| PubMedID- 25597856 | A monoclonal gammopathy of undetermined significance was found. |
| PubMedID- 22084694 | At this point, it was thought that the gammopathy was probably monoclonal gammopathy of undetermined significance. |
| PubMedID- 25695044 | Few years ago, it became evident that all myelomas are preceded by monoclonal gammopathy of undetermined significance [11]. |
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