eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | monoclonal gammopathy of uncertain significance |
| Comorbidity | |monoclonal gammopathy |
| Sentences | 127 |
| PubMedID- 24504138 | Generally, mm is preceded by two premalignant conditions namely monoclonal gammopathy of undetermined significance (mgus) and smoldering (asymptomatic) multiple myeloma (smm) [3, 4]. |
| PubMedID- 24895568 | monoclonal gammopathy of undetermined significance (mgus) is the most common plasma cell disorder, and its prevalence increases with age [1–4]. |
| PubMedID- 21411633 | Tβriii mrna expression was decreased during multiple myeloma progression, with decreased expression in bone marrow specimens from patients with monoclonal gammopathy of undetermined significance (mgus) relative to normal patients, and was decreased in bone marrow from multiple myeloma patients relative to bone marrow from mgus patients (mattioli et al., 2005; zhan et al., 2006) (supplemental figure s1, summarized in supplemental table s1). |
| PubMedID- 24563807 | Cks1 gain is associated with transformation from benign monoclonal gammopathy of undetermined significance (mgus) to more aggressive forms mm and plasma cell leukemias (pcl) and a shorter disease free survival [127]. |
| PubMedID- 22348393 | In many instances mm is preceded by monoclonal gammopathy of undetermined significance (mgus), a pre-malignant state without clinical symptoms of malignancy (1). |
| PubMedID- 24741263 | monoclonal gammopathy of uncertain significance (mgus) is the condition in which an underlying causative disease is not evident. |
| PubMedID- 21760829 | [4] light chain al can be associated with monoclonal gammopathy of undetermined significance (mgus), waldenstrom's macroglobulinemia, and lymphoplasmacytic disorders. |
| PubMedID- 25861350 | She was diagnosed with monoclonal gammopathy of unknown significance (mgus) and autoimmune hemolytic anemia 4 years ago, and treated with cyclophosphamide previously. |
| PubMedID- 25838973 | The mean fancd2 mrna level in myeloma cells (351 ± 268, n = 351) was 4.3-fold higher than in normal plasma cells (npcs) from the bone marrow (81.2 ± 54.1, n = 22) and 1.8-fold higher than in plasma cells from individuals with monoclonal gammopathy of undetermined significance (mgus; 195 ± 207, n = 44). |
| PubMedID- 26077418 | Introduction: the most common plasma cell dyscrasia is monoclonal gammopathy of undetermined significance (mgus) and is defined by the presence of a monoclonal protein on electrophoresis and absence of symptoms. |
| PubMedID- 26474569 | Reports showed that the underlying monoclonal gammopathy of undetermined significance (mgus) progresses to mm, resulting in the co-existence of mgus and aml, particularly in elderly patients [9]. |
| PubMedID- 20086168 | Similarly, cr was not a surrogate marker for survival in patients whose disease had evolved from monoclonal gammopathy of undetermined significance (mgus) or smoldering mm [9], although newer data indicate that all or almost all myelomas arise from a mgus precursor state. |
| PubMedID- 20825629 | The most important risk factor is igm monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 20528908 | Bone formation is primarily impaired in patients with overt osteolysis, whereas no decrease in bone formation is observed in mm without osteolysis or in monoclonal gammopathy of undetermined significance (mgus) (7, 12). |
| PubMedID- 23232072 | We investigated ido1 expression in 25 consecutive patients with symptomatic mm and in 7 patients with either monoclonal gammopathy of unknown significance (mgus; n=3) or smoldering mm (smm; n=4). |
| PubMedID- 24224040 | Monoclonal igm protein (igm m-protein) is observed in wm, diffuse large b-cell lymphoma (dlbcl), chronic lymphocytic leukemia, monoclonal gammopathy of undetermined significance (mgus), and autoimmune disease. |
| PubMedID- 25768011 | These findings may provide some rational for treating patients with monoclonal gammopathy of undetermined significance or smouldering mm i.e. |
| PubMedID- 24326130 | The 162 samples evaluated represented 15 healthy individuals (normal), 22 patients with monoclonal gammopathy of undetermined significance (mgus), 24 with smoldering mm (smm), 74 with newly diagnosed mm (mm-n), and 27 with relapsed/refractory mm (mm-r). |
| PubMedID- 21129295 | monoclonal gammopathy with undetermined significance (mgus) is the most common plasma cell disorder, mgus is an asymptomatic premalignant disorder, which is markedly underdiagnosed in the general population. |
| PubMedID- 22826793 | Here, we report on an ige myeloma patient with igg monoclonal gammopathy of undetermined significance with non-secretory ige. |
| PubMedID- 24198984 | Our patient was found to have a monoclonal gammopathy of unknown significance (mgus) with 0.43 grams of igg kappa. |
| PubMedID- 24327604 | Mm is usually preceded by a pre-malignant stage termed monoclonal gammopathy of undetermined clinical significance (mgus) which progresses to overt mm at a rate of 0.5% to 3% per year [1]. |
| PubMedID- 24527207 | According to uncontrolled studies [123–125] rituximab might be helpful in cidp associated with hematological disorders such as monoclonal gammopathy of undetermined significance and multiple myeloma, but a very recent rct [126] on 54 patients with anti-mag followed up for one year has shown no significant benefit from rituximab compared to placebo in terms of changes in the iss score [78]. |
| PubMedID- 24574631 | [23] even though, it is considered as a single disease, there are many clinical entities (monoclonal gammopathy of undetermined significance, smoldering mm, waldenstrom's macrog lobulinemia, solitary plasmacytoma, systemic amyloidosis, poems syndrome) and cytogenetically distinct entities (translocation of genes (11;14), t (4;14), t (14;16), t (6;14), t (14;20), hyperdiploidy and deletion of 17p), that are currently lumped together; hence, there is an element of subjectivity involved in interpreting the clinical criteria for diagnosis and hence, deciding on therapeutic requirements. |
| PubMedID- 24086494 | Samples and biopsies from normal bone marrows, 26 mcl, 5 monoclonal gammopathy of undetermined significance (mgus) and 20 mm patients' were processed and used after achievement of written informed consent according to the declaration of helsinki. |
| PubMedID- 22429443 | Ferritin levels were increased (> 500 μg/dl) in 165 (46.1%) patients; 322 (90.2%) had hypergammaglobulinemia (> 1.5 g/dl); and 61 adult patients (> 18 years old) (17.1%) had monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 22567028 | Mm can occur de novo or evolve from benign monoclonal gammopathy of undetermined significance (mgus). |
| PubMedID- 23125471 | Serum and urine protein electrophoresis studies were consistent with monoclonal gammopathy of uncertain significance (mgus), and bone marrow biopsy, fow cytometry and chromosome analysis excluded the presence of myelomatous disease. |
| PubMedID- 24182705 | In contrast, if monoclonal gammopathy is due to a monoclonal gammopathy of undetermined significance, treatment options include bortezomib, cyclophosphamide, and dexamethasone for a non-igm monoclonal immunoglobulin and rituximab alone or in combination with cyclophosphamide and dexamethasone for an igm monoclonal immunoglobulin. |
| PubMedID- 25949496 | In our institution, monoclonal gammopathy of undetermined significance (mgus) was detected during investigation of two possible living donors, a condition potentially contraindicating donation. |
| PubMedID- 25886604 | Because cidp has an autoimmune basis, it can occur in association with diseases such as hiv infection and hepatitis c, sjogren's syndrome, monoclonal gammopathy of unknown significance, melanoma, lymphoma, diabetes and inflammatory bowel diseases [12]. |
| PubMedID- 24359546 | A 64 year-old woman with al-amyloidosis secondary to a monoclonal gammopathy of undetermined significance (mgus) referred to our hospital for acute painless drop of vision due to bilateral aion. |
| PubMedID- 24839982 | Interestingly, several studies indicate that monoclonal gammopathy of undetermined significance (mgus) and non-active mm (smoldering mm) represent the avascular phase of pc malignancies, while active intramedullary mm is the vascular phase of the disease. |
| PubMedID- 26157944 | The patient's medical history was significant for hypertension, colonic adenomas, and igm monoclonal gammopathy of unknown significance (mgus). |
| PubMedID- 24349810 | Differential diagnosis included monoclonal gammopathy of undetermined significance (mgus) [2], solitary plasmacytoma, multiple myeloma, waldenstrom macroglobulinemia, primary amyloidosis, and cryoglobulinemia. |
| PubMedID- 25838912 | A 64-year-old female patient with scleroderma, monoclonal gammopathy of undetermined significance, chronic thrush, and kidney failure was admitted to icu with confusion, high grade fevers and 20 lbs weight loss. |
| PubMedID- 23074671 | monoclonal gammopathy of undetermined significance (mgus) is a plasma cell proliferative disorder characterized by a plasma cell level of less than 10% in the bone marrow, a monoclonal paraprotein band less than 30 g/l, and no end organ damage (crab—hypercalcemia, renal insufficiency, anemia, and bone lesions) [14]. |
| PubMedID- 20809955 | In particular, among the most common laboratory tests used are those for vitamin b12 levels (to rule out subacute combined degeneration), parathyroid hormone levels (to rule out hyperparathyroidism), and serum protein electrophoresis with immunofixation (to rule out multiple myeloma or monoclonal gammopathy of undetermined significance (mgus)). |
| PubMedID- 24779000 | Either clinical and population-screening studies indicate that mbl, mimicking what observed in monoclonal gammopathy of undetermined significance (mgus), display the same chromosomal abnormalities and a mutated igvh status usually seen in low-risk cll [3,11,13,16-18]. |
| PubMedID- 20532146 | monoclonal gammopathy of undetermined significance (mgus) is a diagnosis given to patients with monoclonal gammopathy who have no features of multiple myeloma or other malignant disorders. |
| PubMedID- 24467750 | A 69-year-old caucasian woman with monoclonal gammopathy of uncertain significance and chronic dermatomyositis (first diagnosed 5 years ago; pretreated with azathioprine 50mg/day and methylprednisolone 6mg daily following acute exacerbations; azathioprine therapy was stopped months before this admission) presented with weakness as well as muscle and joint pain of recent onset. |
| PubMedID- 24813078 | Mm is also an excellent cancer model to study because it is preceded by an asymptomatic premalignant stage called monoclonal gammopathy of undetermined significance and the development of mm involves sequential acquisition of various gene mutations (figure 1a). |
| PubMedID- 20485371 | Eight patients had coexisting hematological disorders including two with chronic lymphocytic leukemia, two monoclonal gammopathy of undetermined significance, two multiple myeloma and one paroxysmal nocturnal hemoglobinuria. |
| PubMedID- 21415944 | monoclonal gammopathy of undetermined significance (mgus), as defined by the international myeloma working group, is a disorder characterized by a prominent monoclonal protein identified by serum electrophoresis. |
| PubMedID- 25597856 | A monoclonal gammopathy of undetermined significance was found. |
| PubMedID- 24391642 | monoclonal gammopathy of undetermined significance (mgus) consistently preceded development of mm. |
| PubMedID- 20846389 | It has been shown that primary myeloma cells from osteolytic mm patients significantly overexpressed the wnt inhibitor dkk-1 in comparison with the plasma cells from patients with monoclonal gammopathy of undetermined significance (mgus) and normal plasma cells. |
| PubMedID- 24428816 | Mgus: monoclonal gammopathy of undetermined significance. |
| PubMedID- 24171046 | In patients without symptoms, monoclonal igm elevation and with bone marrow plasma cells less than 10%, igm-monoclonal gammopathy of unknown significance (mgus) should also be kept in the list of differential diagnosis. |
| PubMedID- 24429703 | These chromosomal abnormalities are, however, insufficient for malignant transformation, as they are also observed in monoclonal gammopathy of unknown significance, a premalignant syndrome that precedes virtually every mm case23. |