eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | metabolic syndrome x |
| Comorbidity | |obesity |
| Sentences | 300 |
| PubMedID- 23746346 | metabolic syndrome is strictly associated with parental obesity beginning from childhood. |
| PubMedID- 23648313 | obesity is closely associated with the metabolic syndrome (mets) and subsequent low-grade inflammation links to endothelial dysfunction (ed) and cardiovascular disease. |
| PubMedID- 20532017 | In female cases, the incidence of metabolic syndrome associated with obesity after menopause increases rapidly, primarily because of the accumulation of abdominal body fat due to the sudden reduction in estrogen secretion caused by menopause [27]. |
| PubMedID- 20938439 | Background: excessive energy intake and obesity lead to the metabolic syndrome (mets). |
| PubMedID- 21756079 | Objective: based on the role of polycystic ovary syndrome as a cause of metabolic syndrome with chronic anovulation, obesity, hyperinsulinemia and hyperandrogenism, development of effective treatment for its obesity is a priority. |
| PubMedID- 21921649 | To elucidate adult bodily responses in bfmi860 mice that develop juvenile obesity, we studied features of the metabolic syndrome at 20 weeks. |
| PubMedID- 24018165 | Non-alcoholic fatty liver disease (nafld) is the hepatic manifestation of metabolic syndrome including obesity and diabetes which elevate the risk of hepatocellular carcinoma (hcc) especially in male. |
| PubMedID- 22075986 | More recently, jurg introduced the critical new concept of the metabolic inflammasome, which senses metabolic stress and contributes to the onset of the metabolic syndrome associated with obesity and type 2 diabetes. |
| PubMedID- 21525818 | Most patients with nafld have risk factors such as insulin resistance, obesity or other indications of metabolic syndrome. |
| PubMedID- 24416020 | The selective orexin receptor 1 antagonist act-335827 in a rat model of diet-induced obesity associated with metabolic syndrome. |
| PubMedID- 20357360 | The metabolic syndrome associated with obesity is characterized by insulin resistance, hyperglycemia, hypertension, and dyslipidemia, reversible by weight loss (1). |
| PubMedID- 20526390 | The high prevalence of metabolic syndrome may be attributed to abdominal obesity and dyslipidemia characterized by high triglycerides and low hdl cholesterol (table 3). |
| PubMedID- 23383064 | metabolic syndrome is associated with visceral obesity, insulin resistance and an increased risk of cardiovascular diseases. |
| PubMedID- PMC4055882 | Erα undoubtedly plays a role in the estrogenic reduction in ingestive behavior—as evidenced by the fact that the erα agonist ppt decreases food intake and meal size in ovariectomized rats [45], and erα silencing in the vmn results in obesity associated with metabolic syndrome [46]. |
| PubMedID- 23133447 | metabolic syndrome is strictly associated with morbid obesity and leads to an increased risk of cardiovascular diseases and related mortality. |
| PubMedID- 25191539 | obesity, which can lead to the metabolic syndrome, has recently gained attention as a factorthat dramatically increases the risk of arteriosclerotic disease. |
| PubMedID- 22935215 | Inappropriately low lh and fsh concentrations are prevalent in patients with obesity and other features of metabolic syndrome (hypertension and hyperlipidemia), this prevalence may be the result of insulin resistance at the level of the gonadotropin-releasing hormone (gnrh)-secreting neuron because insulin facilitates the secretion of gnrh from neuronal cell cultures [37]. |
| PubMedID- 21147557 | Conclusions: the high prevalence of biochemical and physiological factors of metabolic syndrome, associated with overweight and obesity in mexico city adolescents, increases the risk of premature development of coronary atherosclerosis and diabetes mellitus in this population. |
| PubMedID- 22125461 | Hbot has the advantage of improving obesity in patients with metabolic syndrome, but the fault of causing organ damage by increasing oxidative stress. |
| PubMedID- 21346178 | The insulin resistance syndrome is associated with hyperinsulinemia, obesity, dyslipoproteinemia, hypertension, and abnormalities of several nontraditional risk factors such as endothelial dysfunction, abnormal fibrinolysis, and inflammation (1,2). |
| PubMedID- 23266153 | Results: metabolic syndrome patients with morbid obesity had a lower waist-to-hip ratio, and lower plasma free fatty acid and triglycerides levels at baseline and after the overload than patients without morbid obesity. |
| PubMedID- 22582147 | Since in both vertebrates and in invertebrates δ9 desaturases has key function in cellular lipid partitioning and homeostasis it may be a potential target for therapeutic intervention to control obesity and other aspects of metabolic syndrome (dobrzyn and ntambi 2005). |
| PubMedID- 20092995 | Obtusiloba should be evaluated as a potential complementary treatment option for obesity associated with the metabolic syndrome. |
| PubMedID- 24753685 | obesity, an essential component of metabolic syndrome which includes hypertension, diabetes mellitus, insulin resistance, and dyslipidemia, may contribute to cognitive impairment due to clustering with other vascular risk factors. |
| PubMedID- 22701716 | These data also suggest that modifying the availability or metabolism of saturated fatty acids may limit the inflammation associated with obesity leading to metabolic syndrome. |
| PubMedID- 25911907 | The presence of fatty pancreas represents a meaningful manifestation of metabolic syndrome together with obesity and hepatic steatosis. |
| PubMedID- 24111227 | Ultrasonography-based visceral fat estimation is a promising method to assess central obesity, which is associated with metabolic syndrome. |
| PubMedID- 26064924 | Young rats that received the cafeteria diet for 8 weeks developed metabolic syndrome along with obesity, higher hepatic weight, increased plasma levels of glucose, insulin and triglycerides, and insulin resistance [57]. |
| PubMedID- 25340546 | Background: obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. |
| PubMedID- 20691130 | The aim of the present study was to elucidate whether enteric-coated lf (elf) might improve visceral fat-type obesity, an underlying cause of the metabolic syndrome. |
| PubMedID- 22447857 | Overweight characterized by inappropriate expansion of adipose cells (hypertrophic obesity) is associated with the metabolic syndrome and is caused by an inability to recruit and differentiate new precursor cells. |
| PubMedID- 23805900 | Associations of cardiorespiratory fitness, physical activity, and obesity with metabolic syndrome in hong kong chinese midlife women. |
| PubMedID- 20532015 | In addition to elevated blood glucose levels, patients with type 2 diabetes frequently suffer from several additional conditions such as obesity and other features of metabolic syndrome. |
| PubMedID- 24663160 | Equine metabolic syndrome (ems) is associated with obesity and characterized by insulin resistance, decreased adiponectin, and elevated insulin, leptin, and pro-inflammatory cytokines. |
| PubMedID- 25659889 | Peripheral insulin resistance is a key component of metabolic syndrome associated with obesity, dyslipidemia, hypertension, and type 2 diabetes. |
| PubMedID- 20414465 | Additionally, obesity and the presence of metabolic syndrome are related to increased insulin resistance in overweight and obese copd patients [59, 60]. |
| PubMedID- 21586551 | Furthermore, severe metabolic syndrome, including obesity, dyslipidemia, hyperleptindemia, hyperglycemia, hyperinsulinemia, and glucose intolerance, was observed in high-fat-fed offspring perinatally exposed to 50 mug/kg . |
| PubMedID- 21765599 | (23,24) if xylitol stimulates lipogenesis, it might induce steatosis and obesity, leading to metabolic syndrome. |
| PubMedID- 21645344 | It has become clear that obesity and features of the metabolic syndrome, which encompass glucose dysregulation, dyslipidemia and hypertension, are key risk factors for the development and progression of nafld [1]. |
| PubMedID- 25922847 | Thus, the ability of adipose tissue to expand and match the storage needs of energy surplus may be a key determinant in protection against the metabolic syndrome associated with obesity [72]. |
| PubMedID- 26005080 | obesity is strongly associated with the metabolic syndrome and its atherogenic dyslipidemia resulting from insulin resistance. |
| PubMedID- 21540583 | Background: hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. |
| PubMedID- 22029024 | [40] truncal obesity is associated with metabolic syndrome and insulin resistance. |
| PubMedID- 26558010 | Visceral obesity, a pivotal characteristic of the metabolic syndrome, suppresses the hypothalamic–pituitary–testicular axis, leading to diminished testosterone production. |
| PubMedID- 21668294 | Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. |
| PubMedID- 20957814 | Conclusions: patients with early onset t2dm constitute 27.8% of the total number of diabetic patients attending our clinic; they are characterized by a stronger family history of diabetes, a personal history of obesity and co-morbidities associated with metabolic syndrome. |
| PubMedID- 25833179 | Lipodystrophy diagnosis can be challenging, and it has been suggested that partial forms can be easily misdiagnosed as common central obesity with associated metabolic syndrome. |
| PubMedID- 23991406 | [24] confirmed that sarcopenia as well as obesity affect the development of metabolic syndrome. |
| PubMedID- 25646773 | Nafld refers to a spectrum of hepatic disorders secondary to an increase in hepatic triglyceride (tg) content in the setting of the metabolic syndrome that is associated with obesity, hypertension, hyperlipidemia and type ii diabetes [2]. |
| PubMedID- 22150400 | This association was mainly driven by the central obesity component of the metabolic syndrome. |