eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | melanoma, malignant |
| Comorbidity | |brain metastases |
| Sentences | 53 |
| PubMedID- 21949607 | The brain is a common site of melanoma metastasis, with brain metastases contributing to 20%–54% of all deaths.32 patients at increased risk for brain metastases include males, patients with head and neck mucosal melanomas, and lesions with metastases to ≥3 regional lymph nodes.33 these late-stage patients with brain metastasis generally have a poor prognosis, and treatment options are limited. |
| PubMedID- 24295639 | Background & aim: brain metastases are frequent in patients with metastatic melanoma, indicating poor prognosis. |
| PubMedID- 21204754 | Ipilimumab has also shown promising activity in melanoma patients with brain metastases, and patients with non-small cell lung cancer, renal cell cancer, and castrate-resistant prostate cancer. |
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