eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | c syndrome |
| Comorbidity | |obesity |
| Sentences | 307 |
| PubMedID- 25919692 | obesity complicated by the metabolic syndrome and type 2 diabetes mellitus are commonly comorbid conditions[2]. |
| PubMedID- 23223931 | It is epidemiologically established that obesity is frequently associated with the metabolic syndrome and poses an increased risk for the development of type 2 diabetes mellitus and cardiovascular disease. |
| PubMedID- 25340546 | Background: obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. |
| PubMedID- 24554764 | Kdm3a knockdown leads to immotile round-headed spermatozoa (globozoospermia) and metabolic syndrome associated with obesity and diabetes (okada et al., 2007; inagaki et al., 2009; tateishi et al., 2009; liu et al., 2010) through the regulation of genes involved in histone replacement during spermatogenesis and regulation of gene expression during adipogenesis. |
| PubMedID- 25516385 | Studies in adult populations show that retinal microvascular changes are associated with obesity and components of the metabolic syndrome. |
| PubMedID- 23259259 | Conclusion: acupuncture and moxibustion achieve the significant efficacy on obesity complicated with climacteric syndrome, which is closely related with the pattern/syndrome of the disorder and obesity grade. |
| PubMedID- 26005080 | obesity is strongly associated with the metabolic syndrome and its atherogenic dyslipidemia resulting from insulin resistance. |
| PubMedID- 25430602 | Pcos is underpinned by insulin resistance and is associated with comorbidities including hypertension, dyslipidemia, obesity, and increased risk of metabolic syndrome and type 2 diabetes mellitus [12–15]. |
| PubMedID- 20357360 | The metabolic syndrome associated with obesity is characterized by insulin resistance, hyperglycemia, hypertension, and dyslipidemia, reversible by weight loss (1). |
| PubMedID- 24410812 | Lactoferrin (lf), a multifunctional glycoprotein in mammalian milk, is reported to exert a modulatory effect on lipid metabolism and improve visceral fat-type obesity, an underlying cause of the metabolic syndrome. |
| PubMedID- 24270951 | These transitional nutrition regions are very relevant to this type of research because these areas contain a large number of children with low birth weights who are further exposed to diets containing foods of low cost, high caloric value, and low nutrient quality, which may increase the incidence of obesity and diseases associated with metabolic syndrome (9). |
| PubMedID- 24130367 | Hence, excess mortality in type 2 diabetes has also been attributed to traditional risk factors, such as obesity and other components of the metabolic syndrome (6,7), and to socioeconomic factors (8). |
| PubMedID- 21894292 | Background: nonalcoholic fatty liver disease (nafld) is a clinic-pathological syndrome closely associated with obesity, dyslipidemia, diabetes and atherosclerosis. |
| PubMedID- 26558010 | Visceral obesity, a pivotal characteristic of the metabolic syndrome, suppresses the hypothalamic–pituitary–testicular axis, leading to diminished testosterone production. |
| PubMedID- 24306159 | Sarcopenic obesity is closely associated with metabolic syndrome. |
| PubMedID- 25830228 | While metabolic syndrome is often associated with obesity, 25% of humans suffering from it are not obese and the effect of physical activity remains unclear in such cases. |
| PubMedID- 26090468 | Nafld is the hepatic expression of metabolic syndrome, being frequently associated with obesity, insulin resistance, and dyslipidemia [2]. |
| PubMedID- 20532015 | In addition to elevated blood glucose levels, patients with type 2 diabetes frequently suffer from several additional conditions such as obesity and other features of metabolic syndrome. |
| PubMedID- 21078146 | Children were excluded if they had any genetic syndromes associated with obesity, including cerebral palsy, spina bifida, and hypothyroidism. |
| PubMedID- 23903497 | Results: multiple logistic regression analysis revealed that visceral obesity was independently associated with metabolic syndrome, platelet count, high-density lipoprotein level, and serum viral load in elderly patients (>/=65 years). |
| PubMedID- 24018165 | Non-alcoholic fatty liver disease (nafld) is the hepatic manifestation of metabolic syndrome including obesity and diabetes which elevate the risk of hepatocellular carcinoma (hcc) especially in male. |
| PubMedID- 21383912 | Both factors are associated with obesity and a range of metabolic syndromes (figure 3). |
| PubMedID- 22043170 | Despite its rarity, there is considerable interest in understanding the molecular basis and biochemical pathways of alström syndrome as a monogenic model for metabolic syndrome with obesity, insulin resistance, diabetes mellitus, hypertriglyceridemia and hypertension as common features. |
| PubMedID- 23197236 | [38] demonstrated that obesity, as a component of metabolic syndrome, was independently associated with advanced fibrosis. |
| PubMedID- 22041985 | Childhood obesity and risk of the adult metabolic syndrome: a systematic review. |
| PubMedID- 26078820 | Nafld, as a hepatic manifestation of metabolic syndrome, is associated with dyslipidemia, obesity, insulin resistance, and type 2 diabetes mellitus [1, 2]. |
| PubMedID- 21197447 | Both cachexia and obesity with/without the metabolic syndrome (mets) represent two poles of metabolic abnormalities that are prevalent in patients with copd and are related to adverse clinical outcomes [1]. |
| PubMedID- 25861160 | In animal models, oa-no2 has demonstrated benefits in hypertension [11], vascular neointimal proliferation [12], obesity with the metabolic syndrome [13], and hyperglycemia in diabetes [14]. |
| PubMedID- 24864249 | obesity, as part of the metabolic syndrome, is one of the major risk factors in the development of fatty liver [1, 2]. |
| PubMedID- 25646773 | Nafld refers to a spectrum of hepatic disorders secondary to an increase in hepatic triglyceride (tg) content in the setting of the metabolic syndrome that is associated with obesity, hypertension, hyperlipidemia and type ii diabetes [2]. |
| PubMedID- 24204674 | obesity is strongly associated with metabolic syndrome, hypertension, dyslipidemia and hyperglycemic tendencies that are represented at the molecular level by insulin resistance (ir) [1]. |
| PubMedID- 24753685 | obesity, an essential component of metabolic syndrome which includes hypertension, diabetes mellitus, insulin resistance, and dyslipidemia, may contribute to cognitive impairment due to clustering with other vascular risk factors. |
| PubMedID- 24224148 | Pufas are used for metabolic syndrome related with obesity or diabetes. |
| PubMedID- 22332072 | obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases. |
| PubMedID- 26469529 | obesity is associated with the metabolic syndrome. |
| PubMedID- 20338978 | Earlier studies showed that sedentary behaviour is positively associated with coronary heart disease risk factors, obesity and development of the metabolic syndrome [37]. |
| PubMedID- 24071981 | In recent years the literature has shown an increasing interest in paediatric obesity and the onset of diabetes and the metabolic syndrome in adulthood. |
| PubMedID- 24904871 | Another study reported that hypothalamic obesity is associated with metabolic syndrome and cardiovascular morbidity without increased insulin sensitivity36). |
| PubMedID- 23465506 | Background: asthma has been linked to obesity and the presence of the metabolic syndrome. |
| PubMedID- 26378573 | H rats showed signs of metabolic syndrome leading to visceral obesity with hypertension, glucose intolerance, cardiovascular remodelling and nonalcoholic fatty liver disease. |
| PubMedID- 25861250 | The oa-no2, a nitrated fatty acid and an endogenous ppars agonist, has been reported to have relevant biological effects on inflammation [11], hypertension [12], vascular neointimal proliferation [13], obesity with metabolic syndrome [7], hyperglycemia [14], and proteinuria [15] in diabetes without side effects. |
| PubMedID- 24701367 | The metabolic syndrome commonly associated with obesity may lead to insulin resistance, rendering the body less adept at maximally utilizing glucose, a breakdown product of carbohydrates [175]. |
| PubMedID- 24740690 | Particularly, due to the pathophysiological relevance of acc2 in lipid metabolic syndrome associated with obesity, diabetes, cancer, and cardiovascular disease, acc2 activity regulation has been considered as a candidate target for therapeutic interventions, which essentially requires authentic bioengineered recombinant proteins (abu-elheiga et al. |
| PubMedID- 21966331 | [15] kato and colleagues [20], showed that among the components of metabolic syndrome, abdominal obesity and low hdl-c levels were more frequently observed in patients with multiple, complex coronary lesions. |
| PubMedID- 20972515 | Urbanisation is associated with obesity, hypertension and development of the metabolic syndrome (ms). |
| PubMedID- 25115695 | Hypertension, diabetes mellitus (especially type 2 diabetes mellitus) and metabolic syndrome associated with obesity are rapidly growing public health problems. |
| PubMedID- 21310886 | 1) or excluding abdominal obesity from the definition of the metabolic syndrome (supplementary fig. |
| PubMedID- 20619835 | Background: the metabolic syndrome (mets) is associated with central obesity and leads to increased morbidity and mortality due to cardiovascular disease (cvd). |
| PubMedID- 22567052 | obesity, an integral component of the metabolic syndrome and type 2 diabetes, predisposes to the toxic effects of fatty acids on the myocardium and the additional detrimental effects of cytokines and angiotensin ii released by adipose tissue. |
| PubMedID- 22303936 | How obesity causes symptoms of metabolic syndrome, in particular cardiomyopathies, is still largely unknown. |