Home Contact Sitemap

eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease thalassemia
Comorbidity |iron overload
Sentences 72
PubMedID- 25850001 Furthermore, a pilot trial investigating the effect of amlodipine (a ccb) on iron overload in patients with thalassemia major reported that it can serve as a complementary treatment to standard chelation regimens and may improve the efficacy of iron removal in the heart without the burden of significant side effects [23].
PubMedID- 23516830 In this study production levels of interleukins (il)-12 and il-13 were measured by commercial elisa in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells-from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals.
PubMedID- 21791471 This study evaluates whether iron overload in patients with beta thalassemia intermedia is associated with morbidity.
PubMedID- 24040004 iron overload in patients with thalassemia results from both excessive iron absorption and transfusion.
PubMedID- 23443782 Conclusion: magnetic resonance imaging (t2*) detection is an effective and non-invasive means for detecting myocardial and liver iron overload in patients with beta-thalassemia major receiving blood transfusion.
PubMedID- 21897589 [35] have stated that impaired thyroid function is present in a considerable proportion of transfusion-dependent beta-thalassemia patients with associated iron overload.
PubMedID- 20813008 Cardiac magnetic resonance (cmr) has replaced all other surrogate measurements in the determination of transfusional cardiac iron overload in patients with thalassaemia major.
PubMedID- 23963793 Authors' conclusions: desferrioxamine is the recommended first-line therapy for iron overload in people with thalassaemia major and deferiprone or deferasirox are indicated for treating iron overload when desferrioxamine is contraindicated or inadequate.
PubMedID- 25745550 This comes in harmony with the results of a previous study that was carried out by cheung et al,28 who found that iron overloading in patients with beta-thalassemia major results in alterations of arterial structures with disruption of elastic tissue and calcification.
PubMedID- 25822525 Tnf-α and il-10 were found to be elevated in iron overloaded patients with thalassemia major [30].
PubMedID- 20001472 Background: pituitary iron overload in patients with transfusion-dependent beta-thalassemia may lead to delayed puberty.
PubMedID- 22391807 The objective of this review is to discuss the factors which should be considered when designing clinically useful iron chelators, to present the application of iron chelators in the treatment of iron overload associated with beta-thalassaemia major and sickle cell anaemia, and to highlight the potential applications in the treatment of neurodegenerative disorders and microbial infection.
PubMedID- 20711357 The importance of nutritional immunity as it pertains to iron is exemplified by the increased susceptibility to infection of individuals with iron overload due to thalassemia and primary hemochromatosis, two of the most common genetic diseases of humans [3].
PubMedID- 23830536 Conclusions: the use of amlodipine in conjunction with standard chelation therapy may suggest a new strategy in preventing and treating iron overload in patients with thalassemia major, especially in organs where iron absorption depends on active uptake by calcium channels like the heart.
PubMedID- 25878400 [47] recently reviewed the iron chelating activity of african walnut and wheat grass extracts as to their potential for natural iron removal agents for iron overload associated with thalassemia, which is currently typically treated clinically with desferal.
PubMedID- 19744128 The aim of this study was to measure parathormone (pth) and metabolites of vitamin d and consequently to investigate whether these parameters predispose to myocardial iron overload in patients with beta-thalassaemia major.
PubMedID- 24087894 The effect of hfe polymorphisms on cardiac iron overload in patients with beta-thalassemia major.
PubMedID- 20027547 Dual-echo tfe mri for the assessment of myocardial iron overload in beta-thalassemia major patients.
PubMedID- 19756955 Hepcidin mutation in a beta-thalassemia major patient with persistent severe iron overload despite chelation therapy.
PubMedID- 21071497 Continued improvement in myocardial t2* over two years of deferasirox therapy in beta-thalassemia major patients with cardiac iron overload.
PubMedID- 23056717 Objective: dilated cardiomyopathy is the end result of chronic iron overload in patients with beta thalassemia major.
PubMedID- 24044606 In thalassemia patients with iron overload, regular assessment of bone density from puberty every 2 years if normal, and annually if abnormal, might be required.
PubMedID- 24575259 Background: frequent blood transfusion in patients with beta thalassemia major can lead to iron overload especially in liver.
PubMedID- 22052662 Electrocardiographic consequences of cardiac iron overload in thalassemia major.
PubMedID- 21757620 Reproductive capacity in iron overloaded women with thalassemia major.
PubMedID- 25197009 iron overload in beta-thalassemia major (tm) typically results in iron-induced cardiomyopathy, liver disease, and endocrine complications.
PubMedID- 22900514 The complete treatment of transfusional iron overload in thalassaemia using the deferiprone (l1) and deferoxamine combination is a paradigm to be followed in the treatment of many other metal toxicity conditions.
PubMedID- 24460526 Myocardial iron overload in thalassaemia major.
PubMedID- 20950401 Abnormal iron regulation in patients with thalassaemia intermedia may lead to iron overload even in the absence of transfusions.
PubMedID- 23056768 Objective: hypothyroidism usually appears in the second decade of life and is thought to be associated with iron overload in patients with thalassemia major.
PubMedID- 20662901 Conclusion: transfusional iron overload in patients with thalassaemia could be reduced to normal body iron range levels using effective deferiprone/deferoxamine combinations.
PubMedID- 24555000 [1] transfusional hemosiderosis in major thalassemia patients leads to iron overload and then iron deposition in some organs.
PubMedID- 21808992 Taken together, iron overload in patients with beta-thalassaemia major may potentially result in arterial dysfunction via its effects on the quantity and function of epcs.
PubMedID- 22665732 Most of the endocrine complications in thalassaemia are attributable to iron overload which may be the result of economic circumstances (expense of the chelation therapy), late onset of chelation therapy or poor compliance with the iron chelation therapy.
PubMedID- 25402221 The effects of deferasirox on renal haemodynamics, including glomerular filtration rate (gfr) and renal plasma flow (rpf), were investigated in a phase i, open-label study in beta thalassaemia major patients with iron overload.
PubMedID- 25252297 Assessment of the relationship between fragmented qrs and cardiac iron overload in patients with beta-thalassemia major.
PubMedID- 24919862 Based primarily on the findings of the thalassa (assessment of exjade((r)) in non-transfusion-dependent thalassemia) trial, the approval for deferasirox has recently been expanded to include the management of chronic iron overload in patients with non-transfusion-dependent thalassaemia (ntdt) syndromes.
PubMedID- 24646011 Moreover, chronic conditions associated with ineffective erythropoiesis, such as non-transfusion-dependent thalassaemia (ntdt), may lead to iron overload through increased gut absorption of iron starting in childhood.
PubMedID- 25801075 Methods and materials: in this quasi-experimental study, serum ferritin levels were evaluated in 32 beta-thalassemia major patients with severe iron overload before and after receiving combined deferasirox (30-40 mg kg(-1) day(-1) ) and deferoxamine (40-50 mg kg(-1) day(-1) ) 2 days a week.
PubMedID- 21752315 Methods: twenty-four beta-thalassemia major children with iron overload who received regular blood transfusion were randomly enrolled.
PubMedID- 20631898 Despite iron overload in patients with β-thalassemia, hepcidin levels are not increased.
PubMedID- 22035015 Hypogonadotrophic hypogonadism and diminished gonadal reserve accounts for dysfunctional gametogenesis in thalassaemia patients with iron overload presenting with infertility.
PubMedID- 21531154 Combined chelation treatment may be a better approach for transfusion-dependent thalassemia major patients with iron overload complications because of increased efficacy.
PubMedID- 25988550 Background: mri imaging is an alternative to serum ferritin for assessing iron overload in patients with thalassaemia disease.
PubMedID- 21452907 Pharmacoeconomic considerations in treating iron overload in patients with beta-thalassaemia, sickle cell disease and myelodysplastic syndromes in the us: a literature review.
PubMedID- 23687960 iron overload in beta-thalassaemia major patients is secondary to multiple blood transfusions and increased iron absorption.
PubMedID- 23241074 Conclusion: we conclude that the use of dfx instead of dfo represents a cost-effective use of resources for treatment of iron overload in patients with beta-thalassemia from iran's society perspective.
PubMedID- 22645668 A study done on status of thyroid function and iron overload in patients with beta thalassemia major on deferoxamine in jordan concluded that there is significantly high (p < 0.05) levels of serum ferritin, ft3, zinc, and copper in patients with beta thalassemia major as compared to controls [13].
PubMedID- 25161967 Background: diabetes mellitus is a major complication of iron overload in patients with beta thalassemia major.
PubMedID- 24934354 The hepatic iron overload in beta-thalassemia patients is associated with haemosiderin storage both in kupffer cells and in the cytoplasm of hepatocytes.

Page: 1 2