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eRAM

encyclopedia of Rare Disease Annotation for Precision Medicine




Disease thalassemia
Symptom C0002871|anemia
Sentences 37
PubMedID- 25000650 This patient, with a history of mild anemia due to beta-thalassemia minor and two known transfusion of packed red cells came to an emergency room complaining of severe abdominal cramps.
PubMedID- 20712767 The thalassemias, together with sickle cell anemia and its variants, are by far the most common monogenic diseases.
PubMedID- 23049400 Due to the different pathophysiology of anemia in thalassemia and sickle cell disease, there are significant differences in the pathophysiology of iron overload and iron-related complications in these disorders.
PubMedID- 21637571 The frequency of α-thalassemia in patients with microcytic anemia was significantly higher than in healthy volunteers, regardless of their ethnic origin (p = 0.001).
PubMedID- 23827114 Objective: to investigate the clinical features and therapeutic method for severe aplastic anemia (saa) associated with beta-thalassemia, and to improve the recognition of the disease.
PubMedID- 20871816 thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in malaysia.
PubMedID- 24348256 Dulinska et al., demonstrated that the young's modulus in erythrocytes from patients with hemolytic anemia due to hereditary spherocytosis, thalassemia, or glucose-6-phophate dehydrogenase deficiency is 1.5 to 3.5-fold greater than the young's modulus of normal erythrocytes .
PubMedID- 24639300 In multivariable analysis, homozygous alpha(+)-thalassemia remained associated with anemia (adjusted odds ratio aor = 1.8, p = 0.004) but not with low rbp (aor = 0.6, p = 0.065).
PubMedID- 24130436 In contrast, the frequency of α-thalassemia carriers in patients with microcytic anemia was 25.8%, significantly higher (p < 0.01) than that observed in the sample as a whole and in afro-descendants and euro-descendants.
PubMedID- 18955271 The anemia associated with thalassemia may be moderate to severe depending on the gene mutations involved.
PubMedID- 21444028 The hemoglobinopathies, sickle cell disease and thalassemia, represent diverse causes of anemia of pregnancy, requiring specialized care.
PubMedID- 25883429 Severe hemolytic anemia in beta-thalassemia major and beta-thalassemias/hbe (beta-tm) patients requires giving blood transfusions.
PubMedID- 23402775 thalassemia major presents with chronic hemolytic anemia that requires regular red blood cell transfusions within the first year of life.
PubMedID- 25356075 In general, a heterozygote for thalassemia is diagnosed with a mild anemia (hemoglobin a level 1 or 2 g below normal range), low mean cell volume, low mean corpuscular hemoglobin, elevated hemoglobin a2, and normal or elevated hemoglobin f. during pregnancy, women with thalassemia minor will often show more significant anemia, which is often most prominent during the latter half of the second trimester and early third trimester (4-7).
PubMedID- 25006473 The present study shows the frequent occurrence of iron deficiency anemia in patients with beta thalassemia trait, which can potentially confound the diagnosis of the latter.
PubMedID- 24428927 Rdw has been reported to have a high predictive value for ida and can differentiate beta-thalassemia from other causes of anemia in populations .
PubMedID- 25693142 In-vivo ablation of macrophages improves anemia associated with beta-thalassemia and reduces red blood cell counts in the mouse model of polycythemia vera.
PubMedID- 26097845 The ivsi-6 mutation leads to anemia associated with a β-thalassemia intermedia phenotype.
PubMedID- 26504885 She had chronic, mild microcytic anemia in keeping with beta-thalassemia trait.
PubMedID- 25863092 Conclusion: abnormal hemoglobin with alpha-thalassemia may lead to severe anemia, prenatal diagnosis of thalassemia has the vital significance for eugenic birth.
PubMedID- 25557470 In particular, the v736a tmprss6 polymorphism was associated to moderately lower hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin levels, and in thalassemia carriers with marked anemia and microcytosis.
PubMedID- 22475299 Autoimmune hemolytic anemia in patients with beta-thalassemia major.
PubMedID- 25574363 1,2,37,38 a report on alpha thalassemia with anemia in children’s revealed it should be considered differential diagnosis.39 on comparing the hematological parameters within the four groups, group 1( ida cases) had the most pronounced microcytosis even more than the cases with ida coexistent with α thalassemia mutation (group 3) which had more than that of α thalassemia cases (group 4).1 (mcv group1
PubMedID- 24093062 On the basis of classical hematological parameters, subjects with ida are inappropriately discriminated from subjects with anemia due to thalassemia or chronic disease.
PubMedID- 20585360 Severe iron deficiency anemia without thalassemia was noted (hemoglobin: 8.8 g/dl, rbc: 4.18 million/ul, mcv: 68.2 fl; serum iron: 7 mg/dl, ferritin: 4 ng/ml, uibc: 525 mg/dl) with regards to the microcytic anemia.
PubMedID- 24456650 Heterozygosity for a large duplication of the complete α-globin gene cluster, including the upstream regulatory element hs-40, was identified in a β-thalassemia carrier with severe hemolytic anemia (figure 4b).
PubMedID- 23944358 anemia in patients with coinherited thalassemia and glucose-6-phosphate dehydrogenase deficiency.
PubMedID- 24399969 Found significantly increased plasma concentrations of anti-spectrin nabs in splenectomized patients with β-thalassemia major and in patients with sickle cell anemia (wiener et al., 1986).
PubMedID- 25574177 This study provides the basis for mechanisms of yssxg on thalassemia suffering with hemolysis and anemia of erythrocytes from patient.
PubMedID- 25969661 thalassemia major presents with anemia within the first 2 years of life requiring frequent blood transfusions for sustaining life.
PubMedID- 25429463 The ineffective erythropoiesis and hemolysis causes the anemia, characteristic of patients with β-thalassemia 7.
PubMedID- 23284899 The transplanted homo-βthal mice displayed features of β-thalassemia major with severe anemia as evidenced by markedly decreased rbc count, hemoglobin and hematocrit levels and consequently, exhibit decreased blood viscosity (table 1).
PubMedID- 22065975 The interaction of α-thalassemia with sickle cell anemia (hemoglobin ss disease, hbss) is known to influence hematological indices, reduce hemolytic rate and intravascular sickling, and increase deformation of the red blood cells.
PubMedID- 25002927 It is suggested that hsv infection can aggravate the severity of anemia in patients with beta thalassemia by immune mechanisms.
PubMedID- 19562358 This reference range may be a useful non-invasive tool in risk assessment for fetal anemia, especially due to homozygous alpha-thalassemia-1 or fetal isoimmunization.
PubMedID- 25869286 The thalassemias, together with sickle cell anemia and its variants, are the world's most common form of inherited anemia, and in economically undeveloped countries, they still account for tens of thousands of premature deaths every year.
PubMedID- 24476732 Chronic blood transfusion is the only treatment for severe anemia in patients with beta-thalassemia major.

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