eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | sickle cell anemia |
| Symptom | C0023223|leg ulcer |
| Sentences | 6 |
| PubMedID- 25485858 | Objectives: to assess the clinical effectiveness and safety of interventions for treating leg ulcers in people with sickle cell disease. |
| PubMedID- 25453654 | Mutations that reflect defects in the klotho gene expression may be implicated in the onset of osteonecrosis, priapism, and leg ulcers in patients with sickle cell disease, as a result of oxidative stress and endothelial impairment, important factors in the development and severity of this disease. |
| PubMedID- 24568147 | In jamaica, difference in g6pd status did not affect the total haemoglobin concentration, reticulocyte count, unconjugated serum bilirubin, hb f concentration, plasma haemoglobin concentration and frequencies of clinical severity and of leg ulceration in patients with sickle cell disease . |
| PubMedID- 20872960 | leg ulcers in sickle cell disease. |
| PubMedID- 23922670 | Blood viscosity and the expression of inflammatory and adhesion markers in homozygous sickle cell disease subjects with chronic leg ulcers. |
| PubMedID- 23152256 | Interventions for treating leg ulcers in people with sickle cell disease. |
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