eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | sickle cell anemia |
| Symptom | C0020542|pulmonary hypertension |
| Sentences | 23 |
| PubMedID- 26370739 | Pulmonary endarterectomy as treatment for chronic thromboembolic pulmonary hypertension in sickle cell disease. |
| PubMedID- 22029996 | pulmonary hypertension in sickle cell disease. |
| PubMedID- 25423000 | pulmonary hypertension in sickle cell disease. |
| PubMedID- 25696889 | pulmonary hypertension in sickle cell disease: diagnosis and management. |
| PubMedID- 22029998 | pulmonary hypertension in sickle cell disease. |
| PubMedID- 24515990 | Hypoxic response contributes to altered gene expression and precapillary pulmonary hypertension in patients with sickle cell disease. |
| PubMedID- 25710019 | The cell-derived particles can be considered as potential biological biomarkers for vascular dysfunction and disease severity, being significantly increased in sickle cell disease patients with pulmonary hypertension, sickling crises, acute chest syndrome, stroke, history of thrombosis, or splenectomy, being positively correlated with aortic stiffness, pulmonary artery pressure, and tricuspid regurgitant velocity, and being negatively correlated with aortic distensibility . |
| PubMedID- 26270484 | This study aimed to evaluate the characteristics and severity of pulmonary hypertension in patients with sickle cell disease using detailed echocardiography. |
| PubMedID- 19488751 | Significant, independent associations were found with both elevated ldh concentration and degree of anemia, suggesting that hemolytic and other mechanisms contribute to pulmonary hypertension in patients with sickle cell disease. |
| PubMedID- 22030000 | pulmonary hypertension in sickle cell disease. |
| PubMedID- 22175008 | Moreover, low erythrocyte gln may contribute to alterations in the erythrocyte redox environment and may play a role in hemolysis and pulmonary hypertension in patients with sickle cell disease . |
| PubMedID- 21732836 | A hemodynamic study of pulmonary hypertension in sickle cell disease. |
| PubMedID- 24942020 | Elevated tricuspid regurgitant velocity as a marker for pulmonary hypertension in children with sickle cell disease: less prevalent and predictive than previously thought. |
| PubMedID- 21873028 | Abnormalities in cardiac structure and function in adults with sickle cell disease are not associated with pulmonary hypertension. |
| PubMedID- 23271856 | Previous studies have reported abnormal pulmonary function and pulmonary hypertension among nigerians with sickle cell disease, but there is no report of interstitial lung disease among them. |
| PubMedID- 21510733 | pulmonary hypertension in children with sickle cell disease. |
| PubMedID- 25398989 | Vasculopathy and pulmonary hypertension in sickle cell disease. |
| PubMedID- 22029999 | pulmonary hypertension in sickle cell disease. |
| PubMedID- 22829869 | As such, upregulation of arginase activity and expression has been reported to play a role in various vascular pathologies, such as pulmonary hypertension associated with sickle cell disease ischemia-reperfusion, as well as various animal models of arterial hypertension, sexual arousal, diabetes , , . |
| PubMedID- 26176970 | pulmonary hypertension in sickle cell disease. |
| PubMedID- 22210808 | pulmonary hypertension in patients with sickle cell disease: not so frequent but so different. |
| PubMedID- 22029997 | pulmonary hypertension in sickle cell disease. |
| PubMedID- 20553267 | pulmonary hypertension in sickle cell disease children under 10 years of age. |
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