eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | scleroderma |
| Symptom | C0410000|overlap syndrome |
| Sentences | 2 |
| PubMedID- 25885224 | Most anti-pm/scl antibodies recognize two components, pm/scl-100 and pm/scl-75 , and are found mostly in patients with overlap syndrome (ol) of pm and systemic scleroderma (ssc) (approximately 25%) , as well as in pm or ssc patients (3% to 13%) ; however, they are rarely found in other diseases, such as sjögren’s syndrome (ss) . |
| PubMedID- 24600322 | In the first case, the patient was definitively diagnosed with undifferentiated overlap syndrome with features of polyarthritis, myositis, and scleroderma (dactylitis), possibly induced or exacerbated by adalimumab, and in the second patient a clear diagnosis of dm (with positive anti-dna-ds and jo-1 antibodies) with some features of seronegative polyarthritis (negative rf and anti-ccp antibodies) was made. |
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