eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | sarcoidosis |
| Symptom | C0020437|hypercalcemia |
| Sentences | 6 |
| PubMedID- 24246340 | Objective: to report an uncommon cause of 1,25-dihydroxyvitamin d (1,25oh2d)-mediated hypercalcemia associated with splenic sarcoidosis and illustrate the evaluation and potential role of fluorodeoxyglucose (fdg) positron emission tomography (pet)/computed tomography (ct) in such patients. |
| PubMedID- 24753153 | Overproduction of 1alpha-hydroxylase is held responsible for the development of hypercalcemia in sarcoidosis patients. |
| PubMedID- 24663253 | hypercalcemia in sarcoidosis is due to three mechanistic reasons: (1) systemic conversion of 25-hydroxyvitamin d to 1,25-dihydroxyvitamin d by the enzyme 1-alpha hydroxylase produced by activated monocyte/macrophage system, (2) production of parathormone-related peptide (pthrp) by the sarcoid granuloma, (3) tissue-level conversion of 25-hydroxyvitamin d to 1,25-dihydroxyvitamin d by 1-alphahydroxylase produced by local monocyte/macrophage system in the sarcoid granuloma. |
| PubMedID- 21209801 | Treatment of hypercalcemia due to sarcoidosis is beyond the scope of this paper. |
| PubMedID- 22870420 | A diagnosis of sarcoidosis with severe hypercalcemia induced by interferon therapy was made. |
| PubMedID- 26029574 | Although the emc and sarcoidosis with associated hypercalcemia may have been coincidental in our case, the fact that both lymphadenopathy and hypercalcemia resolved after resection of the primary tumor suggests a more intimate relationship. |
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