eRAM
encyclopedia of Rare Disease Annotation for Precision Medicine
| Disease | rheumatoid arthritis |
| Symptom | C0238790|bone destruction |
| Sentences | 9 |
| PubMedID- 24556956 | Studies of bone destruction associated with rheumatoid arthritis have highlighted the importance of the interaction between the immune and skeletal systems. |
| PubMedID- 25863233 | Osteoclasts are responsible for bone destruction in rheumatoid arthritis, and women show greater disease activity and functional disability than men. |
| PubMedID- 21081190 | bone destruction associated with rheumatoid arthritis (ra) is mainly attributed to the abnormal activation of osteoclasts, which are terminally differentiated cells of monocyte/macrophage lineage that resorb bone matrix. |
| PubMedID- 25770819 | For example, the absence of tnf or il-6 signaling has been found to impair fracture healing (gerstenfeld et al, 2003a; yang et al, 2007), whereas persistent and elevated levels of tnf in rheumatoid arthritis are associated with bone destruction (binder et al, 2013) and systemic daily administration of high-dose tnf in a rat rib fracture model also resulted in impaired healing (hashimoto et al, 1989). |
| PubMedID- PMC4033988 | Thus, controlling il-23 production and function could be a strategy for preventing inflammation and bone destruction in patients with rheumatoid arthritis . |
| PubMedID- 21635718 | Accumulating evidence lends support to the theory that bone destruction associated with rheumatoid arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper t cell subset, 'th17 cells'. |
| PubMedID- 23961657 | Mechanism of bone destruction in rheumatoid arthritis. |
| PubMedID- 23362468 | Regulation of bone destruction in rheumatoid arthritis through rankl-rank pathways. |
| PubMedID- 22172512 | rheumatoid arthritis (ra) is associated with pathological bone destruction mediated by osteoclasts. |
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